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안규정 ( Kyu Jeung Ahn ) 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.2
Pregnancy is a complex metabolic state involving dramatic alterations in the hormonal or cytokine environments (increases in estrogen, progesterone, prolactin, cortisol, human chorionic gonadotropin, placental growth hormone and human placental lactogen, TNF-alpha, resistin, leptin, and a decrease in adiponectin) as well as an increasing burden of fuel utilization by the conceptus. Metabolically, the first trimester is characterized by increased insulin sensitivity and lipogenesis. The second and third trimesters, in contrast, are characterized by insulin resistance and increased lipolysis. The adipose tissue is considered an active organ, capable of secreting substances such as adipokines, which may play a role in the pathogenesis of insulin resistance. Resistin, leptin, serum and placental levels increase as pregnancy progresses, which is in contrast to levels of adiponectin. These levels correlate with the state of increased insulin resistance that develops in the latter stages of pregnancy. (Korean Diabetes J 33:77-82, 2009)
한국인의 비만형 인슐린비의존성 당뇨병 발생기전에 있어서 β₃아드레날린 수용체 유전자 다형성의 의의
고은미(Eun Mi Koh),안규정(Kyu Jeung Ahn),김경아(Kyoung Ah Kim),김연선(Yeun Sun Kim),정재훈(Jae Hoon Choung),민용기(Young Ki Min),이명식(Myung Shik Lee),이문규(Moon Kyu Lee),김종원(Joung Won Kim),김광원(Kwang Won Kim),김성운(Sung Woon 대한내과학회 1997 대한내과학회지 Vol.53 No.6
Objectives : The β₃adrenergic receptor(β₃-AR) may play an important role in the regulation of energy expenditure and lipolysis. A mutation of the β₃- AR gene(Trp64Arg) has been reported to be associated with early onset of non-insulin dependent diabetes mellitus(NIDDM), obesity and syndrome X which are related with insulin resistance. It is well known that Korean NIDDM patients, in contrast to Caucasians, are mainly non-obese and have experienced severe weight loss during the course of disease. We studied the frequency of the mutation in Korean NIDDM patients and non-diabetics control and evaluated the clinical characteristics of Korean obese NIDDM patients. We investigated the frequency of the mutation in NIDDM patients and clinical characteristics of the patients with the mutation in order to elucidate the significance of the mutation in the pathogenesis of NIDDM in Koreans. Methods: We studied 401 NIDDM patients and 99 controls. The NIDDM patients were divided into two groups, non-obese group and obese group, according to their body mass index at diagnosis of the disease. The Trp64Arg mutation was detected by the PCR/RFLP method using restriction enzyme Mva I. Results: The Trp64Arg allele frequency(16M) of NIDDM did not differ from that(16%) of controls. Although the mutant allele frequency was not different between non-obese and obese group both in NIDDM patients and controls, the frequency of patient with the mutant allele was significantly higher in obese NIDDM patients than in non-obese NIDDM patients(38.5% vs. 26.9%, P=0.04). However, no significant differences were found in clinical and laboratory findings between the NIDDM patients with the mutant allele and those without the mutant allele. Conclusion: These data suggest that β³-AR mutation might be associated with Korean obese NIDDM, and other factors might also be associated with the development of obesity and insulin resistance in NIDDM patients.
폐경 전 여성에서 혈청 비타민 D 농도와 인슐린 저항성에 관한 연구
이지혜(Ji-Hye Lee),홍준화(Jun-Hwa Hong),김현진(Hyun-Jin Kim),박강서(Kang-Seo Park),이재민(Jae Min Lee),김병준(Byung-Joon Kim),안규정(Kyu-Jeung Ahn),정비오(Bi O Jeong),김성환(Sung-Hwan Kim),이성규(Seong-Kyu Lee) 동아시아식생활학회 2009 동아시아식생활학회지 Vol.19 No.5
Vitamin D levels have been reported to be associated with diabetes, obesity and metabolic syndrome. There have been studies on the nutritional status of vitamin D in postmenopausal women at Seoul and premenopausal women at Busan, and these studies showed that nearly no relationship between serum vitamin D levels and the obesity index existed. However, there have been no studies that examined about the relationship between serum vitamin D levels and insulin resistance in Korea. In this study, we investigated serum vitamin D levels and the relationship between serum vitamin D levels and insulin resistance (homeostasis model assessment of insulin resistance), obesity index (body mass index, percentage of body fat and waist circumference) in 180 premenopausal women (non-obese women 87.8%, obese women 12.2%) in spring (March~April), fall (September~October) and winter (January~February) at Daejeon. Serum vitamin D levels were lower in winter than in spring-fall, after adjusting for age and the obesity index. The frequency of vitamin D inadequacy (serum vitamin D levels were ≤ 20 ng/mL) was 45.5% in winter and, 23.5% in spring-fall, and which showed that vitamin D inadequacy was higher in winter than in spring-fall. Multiple regression analysis showed that serum vitamin D levels had no relationship with the obesity index or insulin resistance. There was no difference in the obesity index or insulin resistance between the vitamin D inadequacy and normal group, and there was no relationship between serum vitamin D levels and the obesity index or insulin resistance in non-obese and obese premenopausal women, respectively. In conclusion, serum vitamin D levels in premenopausal women at Daejeon were lower in winter than in spring-fall, and the frequency of vitamin D inadequacy was higher in winter than in spring-fall. Serum vitamin D levels had no relationship with the obesity index or insulin resistance in premenopausal women, most of whom were not obese.
척추 골관절염 환자에서의 골밀도와 골다공증성 척추골절의 빈도와의 관계
박준섭 ( Jun Sup Park ),주영실 ( Yeong Shil Joo ),최윤선 ( Yun Sun Choi ),정명아 ( Myeong A Cheong ),하형근 ( Hyung Keun Ha ),정인수 ( In Su Jung ),김시민 ( Si Min Kim ),김병준 ( Byoung Joon Kim ),안규정 ( Kyu Jeung Ahn ),최영길 ( 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.1
Objective: To investigate the association between bone mineral density (BMD) and osteoporotic compression fractures in radiographic spinal osteoarthritis (OA) patients. Methods: Subjects were 382 female patients (ages 45 to 85) from outpatient clinic for osteoporosis and rheumatic diseases. BMD was measured at lumbar spine and hip by dual X-ray absorptiometry (Hologic QDR 2000). The standard anteroposterior and lateral plain radiographs of thoracic and lumbar spine were taken to define spinal OA and vertebral compression fractures. Radiographic spinal OA was defined by grade of disc degeneration and facet joint degeneration. Frequency of vertebral fractures was compared between spinal OA and control patients in relation to their BMD, age, weight, body mass index (BMI) and years post menopause. Results: Higher proportion of fracture cases were observed in spinal OA patients than non-spinal OA patients (34.1%, 44/129 vs. 18.2%, 46/253, p<0.001) despite comparable mean BMD (0.836±0.152 vs. 0.834±0.185, p=0.89) and older mean age (65.8±8.5 vs. 57.8±10.3, p<0.001). In subjects of ages from 65 to 74, spinal OA patients showed significantly higher BMD than non-spinal OA patients (0.784±0.125 vs. 0.719±0.119, p=0.007), but the frequency of fractures seems to be higher than that of non-spinal OA patients (44.9%, 22/50 patients vs. 34%, 19/55 patients, p=0.58). When all study subjects were stratified according to their spine BMD (normal, osteopenia, and osteoporosis), significantly higher proportion of vertebral compression fractures was noted in spinal OA than non-spinal OA patients in osteopenia group (38.5% vs. 13.5%, p<0.001). Conclusion: Higher BMD does not seem to be translated directly into decreased risk of osteoporotic compression fractures in spinal OA patients. Careful assessment of risk factors for osteoporotic fractures and newer methods for assessing bone strength in this group of patients are needed.
인체에서 경구 당부하에 의한 단기간의 혈중 렙틴의 변화에 관한 연구
안규정 關東大學校醫科大學醫科學硏究所 1998 關東醫大學術誌 Vol.2 No.1
Leptin, the peptide encoded by the obese gene, is secreted by adipose cells and plays a role in regulating food intake, energy expenditure, and adiposity. Serum leptin levels are highly correlated with body fat mass in human. Obese individuals have significantly higher circulating leptin than normal, lean subjects. In addition, females have higher serum leptin than males with extremes in energy intake, such as fasting and overfeeding. Whether insulin acutely regulates plasma leptin humans is controversial. AIM of STUDY: To investigate the dynamic profile of plasma leptin during oral glucose feeding. METHOD and SUBJECTS: I examined the time-course characteristics of the glucose on leptin in healthy 12 men (age 32±8) years (mean±SD); BMI 24.0±3.1 kg/㎡) and 12 women(ago 33±10 years; BMI 21.1±1.9 kg/㎡) volunteers. Concentrations of T3, T4, TSH, cortisol, and ACTH, total cholesterol, LDL-cholesterol, HDI-cholesterol, triglycerides, insulin, C-peptides and leptin were measured in the baseline fasting blood sample from an oral GTT. Insulin, C-peptide and leptin were measured in the throughout oral GTT. Serum leptin concentrations were measured by radioimmunoassay. RESULTS: The fasting serum leptin concentrations were higher in women than in men in spite of the BMI was higher in men than in women. The glucose, insulin and C-peptide increased significantly but tile leptin level decreased significantly during a oral glucose tolerance test (P<0.05). CONCLUS1ON: Plasma leptin concentrations are rapidly suppressed by the loading of oral glucose in humans in vivo. Further studies are needed to define the role of the oral glucose as well as other GI hormones in the regulation of leptin secretion.
동맥혈 칼슘 자극 검사로 진단된 국소성 췌도 세포 증식증 1예
윤진훈,안규정,주영실,김병준,김성훈,권계형,정명아,양진수,정인수,김충현,조성범,이태석,김은경 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4
We report a 40-year-old female patient with clinical findings suggestive of insulinoma. Although imaging studies did not reveal any tumors in the pancreas, a selective arterial calcium stimulation test (SACI), procedurally simpler and more effective than transhepatic pancreatic venous sampling, was performed. And then near total pancreatectomy was carried out because the possibility of small insulinoma could not be completely excluded. Grossly, the surgically removed pancreas did not reveal any tumors. However, the pancreas exhibited islets cell hyperplasia. To our knowledge, this is the first reported authentic case in a Korean adult of islet-cell hyperplasia diagnosed by selective arterial calcium stimulation test