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심진형,김민주,박주영,Ruby Gupta Pati,윤영필,김성은,송해룡,조동우 한국조직공학과 재생의학회 2015 조직공학과 재생의학 Vol.12 No.5
Osteomyelitis, an infection and inflammation of bone marrow, often progresses to chronic stage because of delay in diagnosis and treatment. Once it becomes chronic, intravenous antibiotics therapy is no longer effective as swollen surrounding tissue interrupts blood flow into the infected tissue. In severe cases, debridement of the necrotic tissue becomes necessary to prevent further infection. In this study, for the first time, we produced three-dimensional (3D) printed antibiotics-loaded biodegradable poly-ε-caprolactone/poly(lactic-co-glycolic acid) scaffold for treatment of chronic osteomyelitis. Subsequent bone regeneration in debrided site was also observed with the customized scaffolds fabricated using 3D printing. Tobramycin, one of the most widely used antibiotics in orthopedic surgery, was chosen due to its thermostable nature compliant to the heat-based fabrication conditions. In in vitro tests, antibacterial and anti-inflammatory effects and release profile of tobramycin from the scaffold were evaluated to verify the potential of our scaffold as a drug delivery system. In addition, in vivo efficacy of the developed drug loaded scaffolds for treatment of chronic osteomyelitis was also examined in a rat model.
골조직 재생을 위한 자유형상제작 기반 BMP-2 서방출형 HA-PLGA 인공지지체 개발
심진형(Jin-Hyung Shim),박정규(Jung Kyu Park),김종영(Jong Young Kim),강경신(Kyung Shin Kang),한세광(Sei Kwang Hahn),조동우(Dong-Woo Cho) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
Solid freeform fabrication (SFF) based three dimensional scaffolds for bone regeneration were successfully fabricated with blend of poly(lactic-co-glycolic acid) grafted hyaluronic acid (HA-PLGA) and polyethyleneglycol (PEG) encapsulating intact BMP-2. HA-PLGA was synthesized by the conjugation between adipic acid modified HA (HA-ADH) and PLGA. PEG was blended with HA-PLGA to encapsulate BMP-2 in chloroform without denaturation, which were exploited to fabricate tissue engineered scaffolds. Multi-head deposition system, a SFF technology, was used to fabricate 3D scaffolds. In-vitro release tests confirmed the sustained release of intact BMP-2 from the scaffolds up to a month. After the in-vitro assessments of proliferation and differentiation, the blended HA-PLGA/PEG/BMP-2 scaffolds were implanted into the calvarial bone defects in SD rats. Micro-CT and histological analyses revealed effects of HA-PLGA/PEG/BMP-2 scaffolds on bone regeneration.
심진형(Jin-Hyung Shim),윤원수(Won Soo Yun),고태조(Tae Jo Ko) 한국기계가공학회 2016 한국기계가공학회지 Vol.15 No.2
The process of three-dimensional (3D) printing (also known as “rapid prototyping” and “additive manufacturing”) uses computer-created digital models to produce 3D objects with a desired shape by stacking materials through a layer-by-layer process. The industrial potential and feasibility of 3D printing technology were recently highlighted in President Obama’s State of the Union address in 2013. Since his speech, worldwide investment in and attention toward 3D printing technology have increased explosively. In addition, a number of 3D printing technology-based start-up companies have been established and evaluated as emerging enterprises making successful business models. In this paper, successful start-up companies (domestic and overseas) based on 3D printing technology will be reviewed.
골 조직공학을 위한 자유형상제작 방식의 3차원 인공지지체 제작 및 In Vitro 특성 평가
심진형 ( Jin Hyung Shim ),이정섭 ( Jung Seob Lee ),김종영 ( Jong Young Kim ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.1s
Tissue engineering is an emerging technique which has the potential to regenerate and repair damaged tissues or organs. In this paper, three-dimensional (3D) scaffold fabricated by solid freeform fabrication (SFF) technology and its mechanical property and cell adhesion characteristic were described. Polymer deposition system (PDS), which can dispense biodegradable polymers such as polycaprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA), was developed to fabricate a 3D scaffold for tissue engineering. In this study, PCL, PLGA, and blended PCL/PLGA were used as scaffolding materials. The dispensing conditions for each polymer were investigated using single-line test. Based on the result of single-line test, 3D scaffolds with fully interconnected 600 im pores were successfully fabricated by the PDS. Overall size of the scaffold was fixed at 25£ ̄10£ ̄4 mm which was targeted for application to spine regeneration. Effect of PCL, PLGA, and blended PCL/PLGA on compressive mechanical property of scaffolds was analyzed. In addition, in vitro cell interactions of scaffolds on MC3T3-E1 cells were evaluated using cell counting kit assay.