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골조직 재생을 위한 자유형상제작 기반 BMP-2 서방출형 HA-PLGA 인공지지체 개발
심진형(Jin-Hyung Shim),박정규(Jung Kyu Park),김종영(Jong Young Kim),강경신(Kyung Shin Kang),한세광(Sei Kwang Hahn),조동우(Dong-Woo Cho) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
Solid freeform fabrication (SFF) based three dimensional scaffolds for bone regeneration were successfully fabricated with blend of poly(lactic-co-glycolic acid) grafted hyaluronic acid (HA-PLGA) and polyethyleneglycol (PEG) encapsulating intact BMP-2. HA-PLGA was synthesized by the conjugation between adipic acid modified HA (HA-ADH) and PLGA. PEG was blended with HA-PLGA to encapsulate BMP-2 in chloroform without denaturation, which were exploited to fabricate tissue engineered scaffolds. Multi-head deposition system, a SFF technology, was used to fabricate 3D scaffolds. In-vitro release tests confirmed the sustained release of intact BMP-2 from the scaffolds up to a month. After the in-vitro assessments of proliferation and differentiation, the blended HA-PLGA/PEG/BMP-2 scaffolds were implanted into the calvarial bone defects in SD rats. Micro-CT and histological analyses revealed effects of HA-PLGA/PEG/BMP-2 scaffolds on bone regeneration.
골 조직공학을 위한 자유형상제작 방식의 3차원 인공지지체 제작 및 In Vitro 특성 평가
심진형 ( Jin Hyung Shim ),이정섭 ( Jung Seob Lee ),김종영 ( Jong Young Kim ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.1s
Tissue engineering is an emerging technique which has the potential to regenerate and repair damaged tissues or organs. In this paper, three-dimensional (3D) scaffold fabricated by solid freeform fabrication (SFF) technology and its mechanical property and cell adhesion characteristic were described. Polymer deposition system (PDS), which can dispense biodegradable polymers such as polycaprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA), was developed to fabricate a 3D scaffold for tissue engineering. In this study, PCL, PLGA, and blended PCL/PLGA were used as scaffolding materials. The dispensing conditions for each polymer were investigated using single-line test. Based on the result of single-line test, 3D scaffolds with fully interconnected 600 im pores were successfully fabricated by the PDS. Overall size of the scaffold was fixed at 25£ ̄10£ ̄4 mm which was targeted for application to spine regeneration. Effect of PCL, PLGA, and blended PCL/PLGA on compressive mechanical property of scaffolds was analyzed. In addition, in vitro cell interactions of scaffolds on MC3T3-E1 cells were evaluated using cell counting kit assay.
복합 조직 재생을 위한 자유형상제작기반 Multi-head tissue/organ building system 의 개발
심진형(Jin-Hyung Shim),이정섭(Jung-Seob Lee),김종영(Jong Young Kim),조동우(Dong-Woo Cho) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
The aim of this study is to develop an advanced method for regeneration of three dimensional (3D) tissue or organ. The multi ?-head tissue/organ building system (MtoBS) which can deposit two or more biomolecules and various synthetic biomaterials was developed to regenerate heterogeneous tissue. The MtoBS possessing 6 heads was developed to build 3D pre-tissue in which structural, physiological, and anatomical factors were considered. Two heads are designed for synthetic biomaterials as a framework, another two are for cell dispensing, and the others are for protein dispensing. Feasibility of MtoBS for building 3D pre-tissue was shown by dispensing three different biomaterials into one structure. It was proved that position and volume control of two different hydrogel were controllable in the MtoBS. In conclusion, the MtoBS is expected to be a promising system for regeneration of heterogeneous tissue.
심진형(Jin-Hyung Shim),윤원수(Won Soo Yun),고태조(Tae Jo Ko) 한국기계가공학회 2016 한국기계가공학회지 Vol.15 No.2
The process of three-dimensional (3D) printing (also known as “rapid prototyping” and “additive manufacturing”) uses computer-created digital models to produce 3D objects with a desired shape by stacking materials through a layer-by-layer process. The industrial potential and feasibility of 3D printing technology were recently highlighted in President Obama’s State of the Union address in 2013. Since his speech, worldwide investment in and attention toward 3D printing technology have increased explosively. In addition, a number of 3D printing technology-based start-up companies have been established and evaluated as emerging enterprises making successful business models. In this paper, successful start-up companies (domestic and overseas) based on 3D printing technology will be reviewed.
코 성형을 위한 코 보형물 형태의 인공지지체 설계 및 제작과 코 연골조직의 재생
정진우(Jin Woo Jung),장진아(Jinah Jang),심진형(Jin-Hyung Shim),김성원(Sung Won Kim),조동우(Dong-Woo Cho) 대한기계학회 2012 大韓機械學會論文集B Vol.36 No.11
이상적인 코 보형물은 환자가 원하는 모양을 그대로 재현하면서, 그 상태를 안정적으로 유지할 수 있는 재료적 특성을 지녀야 한다. 현재 보편적으로 사용되고 있는 실리콘 코 보형물은 면역 반응이나 피부를 뚫고 돌출하는 문제점 등이 보고되고 있다. 이러한 부작용을 최소화 하기 위해 본 연구에서는 조직공학 기술을 이용하여 새로운 코 성형술을 제안하고자 한다. 조직공학 기반의 코 성형술의 가능성을 확인하기 위해 코 보형물 형상의 인공지지체를 상용 CAD 소프트웨어와 자유형상제작 기술 중에 하나인 다축 적층 시스템을 이용하여 설계 및 제작하였다. 그리고 코 성형술 인공지지체로서의 사용이 적합한지 확인하기 위해 비중격 유래 연골 세포를 이용하여 세포 증식, 기능 실험을 수행하였다. Implants for rhinoplasty should ideally be biocompatible and possess long-term stability after implantation. Silicone implants are most widely used for rhinoplasty. However, these implants suffer from problems related to high extrusion and infection rates. To minimize these complications, we propose a novel augmentation rhinoplasty technique using tissue engineering. To demonstrate its feasibility, a nasal-implant-shaped scaffold was designed using commercialized CAD software and fabricated using a Multi-head Deposition System, which is a solid freeform fabrication system that dispenses material. In vitro cell proliferation and chondrogenic differentiation tests were carried out using nasal septal chondrocytes.
자유 형상 제작 방식의 다축 적층 시스템 개발 및 쥐 모델을 이용한 PCL/PLGA/TCP 인공지지체의 골 형성 능력 평가
김종영(Jong Young Kim),심진형(Jin-Hyung Shim),김상헌(Sang-Heon Kim),이종원(Jong-Won Rhie),조동우(Dong-Woo Cho) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.5
We investigated the validity of using SFF(solid free-form fabrication)-based scaffolds seeded with osteoblasts, and human umbilical vein endothelial cells (HUVECs) to enhance bone regeneration capacity. To accomplish this goal, SFF-based polycaprolactone (PCL)/poly-lactic-co-glycolic acid (PLGA)/tri-calcium phosphate (TCP) scaffolds were fabricated using a multi-head deposition system (MHDS). The blended PCL/PLGA/TCP scaffolds were seeded with osteoblasts and HUVECs and implanted into calvaria defect model in rats. At 8 and 12 weeks after implantation, micro-computed tomography (μ-CT), reverse transcription polymerase chain reaction (RT-PCR), and histological assays were conducted to know the effects of SFF-based scaffolds on osteogenesis. In vivo results indicated scaffolds in the osteoblast-HUVEC group had the largest area of new bone tissue. Therefore, we demonstrated through μ-CT and histological assays that scaffolds seeded with both human osteoblasts and HUVECs were superior to other groups.
이식거부반응을 줄이기 위한 cyclosporine A 탑재형 약물전달체의 개발
송태하(Tae-Ha Song),장진아(Jinah Jang),심진형(Jin-Hyung Shim),조동우(Dong-Woo Cho) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
Systemic administration of Cyclosporine A (CsA) is frequently associated with a number of side effects which restrict the use of effective dose of immunosuppressant drug. For the purpose of local and controlled delivery of CsA, scaffoldbased CsA delivery system was developed. CsA-Poly(lactic-co-glycolic) acid(PLGA) microspheres-loaded drug carriers were prepared using Multi-head Tissue/Organ Building System which is based on the 3D printing technique. Proinflammatory cytokine expressions, which are secreted by Concanavalin A activated spleen cells such as Interleukin-2, Interleukin-17 and Interferon-gamma were significantly decreased by acting of CsA-loaded drug carrier in-vitro. Human lung fibroblasts-seeded CsA-loaded drug carriers were subcutaneously implanted into the BALB/c mouse model. Infiltration of mononuclear cells and CD4+, CD8+ T-cell populations at the site of implantation were investigated by H&E staining and immunohistochemistry. Mononuclear cells infiltration and population of T-cells were significantly suppressed by CsA-loaded drug carrier in-vivo. These results show that the CsA-loaded drug carrier can be a promising solution for local and controlled delivery of CsA.
외이 재생을 위한 세포 프린팅 기반 복합 조직 구조물의 개발
이정섭(Jung-Seob Lee),정진우(Jin Woo Jung),심진형(Jin-Hyung Shim),오정훈(Jeong-Hoon Oh),조동우(Dong-Woo Cho) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
Tissue engineering is an interdisciplinary field to regenerate and reconstruct damaged tissues and organs. Especially, the cell printing enabling the regeneration of the target tissue has been considered to be a promising technology. However, the cell printing technology is known to be difficult to fabricate the 3D composite tissue with complex shape. In this study, we used 3D printing technology including multiple cells positioning technology and a sacrificial layer process to regenerate various tissues as well as an ear. The main part was printed with poly-caprolactone (PCL) and multiple cells-laden hydrogel. At the same time, poly-ethylene-glycol (PEG) was also deposited as a sacrificial layer to support the main part. After complete fabrication, PEG can be easily removed in aqueous solutions, and the procedure for removing PEG has no effect on the cell viability. Though 3D printing technology, the various composite tissues were fabricated with the desired shape and separately printed cells in the structure also had good cell viability. As a result, the possibility of fabricating the complex composite tissue using 3D printing technology which allowed tissue formation was confirmed.