http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
활동기 염증성 장질환 환자의 관해 유도 치료 후 혈중 Leptin, Adiponectin, Resistin, Visfatin의 변화
황보영 ( Young Hwangbo ),김효종 ( Hyo Jong Kim ),심재준 ( Jaejun Shim ),장재영 ( Jae Young Jang ),동석호 ( Seok Ho Dong ),김병호 ( Byung Ho Kim ),장영운 ( Young Woon Chang ) 대한장연구학회 2010 Intestinal Research Vol.8 No.2
Background/Aims: The aim of this study was to evaluate the change in circulating levels of adipokines, including leptin, adiponectin, resistin, and visfatin, after induction therapy of patients with active inflammatory bowel disease (IBD). Methods: We prospectively evaluated 20 patients with Crohn’s disease (CD) and 14 patients with ulcerative colitis (UC) who received induction therapy. The disease activity, body mass index (BMI), and C-reactive protein (CRP) and serum adipolines levels were checked before treatment and 10 weeks after treatment. Results: After induction therapy, significant reduction of disease activity was noted in patients with CD (CD activity index, 267.9±73.7 vs. 50.8±36.5, P<0.001) and patients with UC (Mayo score, 9.8±2.2 vs. 1.4±1.6, P<0.001). The mean serum leptin, adiponectin, resistin, and visfatin levels were 4.0±2.7 ng/mL and 4.4±2.3 ng/mL (P=0.323), 27.0±20.5 μg/mL and 33.8±26.5μg/mL (P=0.084), 9.0±4.0 ng/mL and 10.2±3.2 ng/mL (P=0.108), and 4.6±3.7 ng/mL and 2.5±4.1 ng/mL (P=0.046) before and after infliximab treatment, respectively. No significant correlation between the changes in BMI, CRP level, or the clinical indices of activity and alterations of the measured adipokines was demonstrated. Conclusions: The serum levels of leptin, adiponectin, and resistin showed no significant alterations, whereas the serum visfatin level decreased significantly after induction therapy, suggesting a possible pro-inflammatory property of visfatin and a role as a marker of successful therapy of IBD. (Intest Res 2010;8:151-161)
박재현 ( Jae Hyun Park ),김효종 ( Hyo Jong Kim ),손성동 ( Seong Dong Sohn ),황보영 ( Young Hwangbo ),심재준 ( Jaejun Shim ),장재영 ( Jae Young Jang ),동석호 ( Seok Ho Dong ),김병호 ( Byung Ho Kim ),장영운 ( Young Woon Chang ),장 대한장연구학회 2011 Intestinal Research Vol.9 No.1
The etiology of Crohn`s disease, which is a chronic inflammatory condition that potentially involves any location of the alimentary tract from the mouth to the anus, is unknown. However, there is strong evidence that vascular damage could play a role in the pathogenesis of Crohn`s disease. Crohn`s disease is mediated by multifocal gastrointestinal infarctions, which occur at an early stage in the disease process. Persistent activation of coagulation in patients with Crohn`s disease has been shown. In contrast, hemophilia is an inherited disorder of coagulation. The deficiencies of clotting factors usually involve occult or overt bleeding. The pathogenic mechanisms of Crohn`s disease and hemophilia are incompatible. An association between Crohn`s disease and hemophilia has not been reported in Korea. We managed 21- and 33-year-old men with Crohn`s disease associated with hemophilia, who presented with hematochezia. (Intest Res 2011;9:9-39)