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      • 우황(牛黃)의 독성(毒性)과 부작용에 관한 문헌적 고찰

        심우형 ( Woo Hyung Sim ),구진숙 ( Jin Suk Koo ),노성수 ( Seong Soo Roh ),서부일 ( Bu Il Seo ) 한약응용학회 2017 한약응용학회지 Vol.17 No.2

        Bovis Calculus is in use in the Korean medicine. The Korean medical doctors use Bovis Calculus for clearing away heat and eliminating toxin(淸熱解毒), relieving convulsion and spasm(熄風止痙), etc. We investigated toxicity, poisoning symptoms, side effects, poisoning treatment and prevention against poisoning of Bovis Calculus. The results were summarized as follows: 1. The main ingredients of poisoning are cholic acid, bile salt, etc. The ingredients of poisoning from Bovis Calculus mainly can cause stimulating symptoms on digestive system, circulatory system, nervous system, etc. And some of herbal prescriptions including Bovis Calculus can cause hypersensitive reaction. 2. The representative methods of poisoning treatment in the western medicine are promotion of vomiting, washing out the stomach, and symptomatic treatment, etc. 3. The representative methods of poisoning treatment in the Korean medicine take advantage of herbs. And Korean medical doctors should meet symptoms as patients call for attention. 4. In order to prevent against poisoning of Bovis Calculus, the patients should keep usage, dosage and notes.

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        오가피(五加皮) 수피(樹皮)와 근피(根皮)의 MIA 유도 골관절염 흰쥐에 미치는 영향 비교

        심우형 ( Woo-hyung Sim ),서부일 ( Bu-il Seo ) 대한본초학회 2018 大韓本草學會誌 Vol.33 No.5

        Objectives : This study was designed to compare the effects of acanthopanax stem bark (ASB) and acanthopanax root bark (ARB) on the monosodium iodoacetate (MIA)-induced osteoarthritis rats. Methods : The antioxidant activities were evaluated through radical scavenging assays using 2,2'-azino-bis (3- ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Also, we examined total poly phenol and flavonoids contents. Osteoarthritis was caused by injection MIA(50 ㎕ with 80 ㎎/㎖) into the knee joint cavity of rats. Rats were divided by 4 groups (normal group, control group, ASB treated group, ARB treated group, each n=6). The changes in the levels of reactive oxygen species (ROS), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum were analyzed after experiment. Also, the anti-oxidant, inflammatory protein levels were investigated western blot analysis. Knee joint tissue, histopathological observation hematoxylin & eosin staining and safranin-O staining were measured. Results : In the present study, ARB treated group showed superior inhibitory effects on the inflammatory parameters than the ASB treated group. ARB aqueous extract was effective in antioxidant measurements. The administration of ARB showed a significant reduction of changes in relative hind paw weight distribution. Morever, it decreased ROS, ALT and AST levels in serum, compared with those of the control rats. The ARB administration inhibited the biomarkers of inflammatory in tissues. Conclusions : ASB aqueous extract and ARB aqueous extract have a great effect on osteoarthritis, and ARB aqueous extract has excellent effect on osteoarthritis through antioxidant and anti-inflammation.

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