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Seasonal Variations and Correlations between Vitamin D and Total Testosterone Levels
심무열,김수현,김광민 대한가정의학회 2017 Korean Journal of Family Medicine Vol.38 No.5
Background: Some studies have provided evidence for a possible association between vitamin D and testosterone levels; however, the evidence from studies in Koreans is inconsistent. In addition, insufficient evidence is available to support an association between seasonal variations in vitamin D and testosterone levels in Koreans. Therefore, we aimed to investigate the association between vitamin D and testosterone levels, and between seasonal varia-tions in these levels in Korean men.Methods: This cross-sectional study included 1,559 men, aged 25–86 years, who underwent a medical examina-tion. We measured serum 25-hydroxyvitamin D (25[OH]D) and total testosterone levels, and compared other labo-ratory test results and patient lifestyle characteristics. On the basis of sample collection time, we categorized pa-tients into four seasons, and analyzed seasonal variability in 25(OH)D and total testosterone levels.Results: The average participant age (±standard deviation) was 53.3±8.8 years, and the average serum 25(OH)D and total testosterone levels were 15.9±7.0 ng/mL and 5.1±1.6 ng/mL, respectively. In the analysis of variance (ANOVA) model, no significant association was found between 25(OH)D and testosterone levels (P=0.51). ANOVA of the average 25(OH)D levels in season-based groups revealed significant seasonal variations in 25(OH)D levels (P-value for trend <0.001). No significant association was found between seasonal variations in total testosterone levels (P=0.06). However, after adjustment for confounding variables, total testosterone and 25(OH)D showed sig-nificant seasonal variability (P=0.007 and P<0.001, respectively).Conclusion: We found no significant correlation between serum 25(OH)D and total testosterone levels in Korean men. Moreover, serum 25(OH)D and total testosterone levels showed significant seasonal variations.