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인삼(人蔘)이 생쥐의 남성 생식세포 GC-1 Spermatogonia의 항산화에 미치는 영향
심경준 ( Kyung Jun Shim ),강지웅 ( Ji Ung Kang ),최봉재 ( Bong Jae Choi ),박수연 ( Soo Yeon Park ),장문석 ( Mun Seog Chang ),박성규 ( Seong Kyu Park ) 대한본초학회 2009 大韓本草學會誌 Vol.24 No.2
Objectives: Previously we reported that the roots of Panax ginseng C.A. Meyer (Araliaceae) increased sperm count and motility, also induced spermatogenesis via cAMP-responsive element modulator(CREM) activation in rat testes. In this study, for the first step of spermatogenesis in germ cell lines, the antioxidant activity of Panax ginseng were examined in mouse GC-1 spermatogonia cells. Methods: The extract was studied on diphenyl-picryl-hydrazyl (DPPH) radical scavenging activity, GC-1 cell viability by a modified MTT assay, H2O2-induced cytotoxicity by MTT assay and lipid peroxidation by malondialdehyde (MDA) formation, respectively. Results: The results showed that the extract scavenged DPPH radical with the IC50 being 0.631 mg/ml. The extract at concentrations of 5, and 10, 50, 100, 250 μg/ml increased GC-1 cell viability significantly(p<0.05, and p<0.01). Hydrogen peroxide-induced cytotoxicity (73.8%, p<0.01) was blocked by the extract at concentrations of 50, and 100, 250, 500 μg/ml significantly (p<0.05, and p<0.01). The extract at concentrations of 10, and 50 μg/ml decreased the MDA formation on hydrogen peroxide-induced lipid peroxidation. Conclusions: In conclusion, the extract of Panax ginseng has potent antioxidant activity and increases the survival rate of GC-1 spg cells against H2O2-induced cytotoxicity.
SD계 흰쥐에서 마황 추출물의 아급성 경구 독성 시험 연구
최동기 ( Dong Gi Choi ),심경준 ( Kyung Jun Shim ),최봉재 ( Bong Jae Choi ),박수연 ( Soo Yeon Park ),장문석 ( Mun Seog Chang ),박성규 ( Seong Kyu Park ) 대한본초학회 2008 大韓本草學會誌 Vol.23 No.4
Objectives: Ephedrae herba, also known as Ma-huang, is a traditional Korean medicinal herb. It has been used to treat asthma, nose and lung congestion, and fever with anhidrosis for centuries. Recently, Ma-huang was used as a source of ephedrine in many dietary supplements for weight reduction in the United States. The objective of this study was to investigate the subacute toxicity of ephedrae herba extract in rats. Methods: SPF Sprague-Dawley male rats were administered orally with ephedrae herba extract for 4 weeks as several doses(0, 125, 250, 500, 1,000, and 2,000 mg/kg). We examined number of deaths, clinical signs, body weights and gross findings for experimental period. Results: No dead animals were found during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, hematology, serum biochemistry, and other findings. Conclusions: In conclusion, above data suggest that no observed adverse effect level of ephedrae herba extract in SD rats might he over 2,000 mg/kg/day in this study.