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신한보,최명수,이채민,김지은,조수지,김혜인,이나래,인경수 대한미생물학회 2014 Journal of Bacteriology and Virology Vol.44 No.3
Human Respiratory Syncytial virus (hRSV) is a leading cause of severe lower respiratory tract diseases in the pediatricpopulation.hRSV frequently causes severe morbidity and mortality in high risk groups including infants with congenitalheart disease and the immunosuppressed patients. Although hRSV is recognized as a major public health threat andeconomic burden worldwide, there is no licensed vaccine and effective therapeutic agent. Viral nonstructural (NS) proteinshave been known to play multiple functions for efficient viral replication and pathogenesis. Especially, diverse functionsof influenza A virus NS1 have been extensively studies. Recent studies demonstrated that NS1 and NS2 of RSV alsoexert diverse functions to modulate cellular environment and antiviral immune responses. Since NS proteins of RSV arerequired for efficient replication and pathogenesis, NS mutant viruses have been tested as live-attenuated vaccines. Thisreview will outline the recent progress in understanding the various functions of RSV NS1 and NS2.