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- 저자 : 신정미(Shin, Jung Mi) (검색결과 30 건)
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Bee Venom Inhibits DU-145 Human Prostate Cancer Cell Growth Through Inactivation of NF-${\kappa}$B
신정미,송호섭,Shin, Jung-Mi,Song, Ho-Sueb The Korean Acupuncture Moxibustion Medicine Societ 2011 대한침구의학회지 Vol.26 No.6
목적 : 이 연구는 봉독이 NF-${\kappa}$B의 활성억제를 통하여 전립선 암세포주인 DU-145 세포의 성장을 억제하 는지를 확인하고 그 기전을 살펴보고자 하였다. 방법 : 봉독을 처리한 후 DU-145의 성장억제를 관찰하기 위해 WST-1 assay를 시행하였고, 세포자멸사의 관찰에는 DAPI staining assay를 통한 세포형태관찰을 시행하였으며, 염증관련유전자 발현 관찰에는 western blot analysis를 시행하였고, 세포자멸사와 연관된 NF-${\kappa}$B의 활성 변화를 관찰하기 위해 EMSA와 luciferase assay를 시행하였으며, DU-145에서 봉독과 NF-${\kappa}$B의 상호작용을 관찰하기 위해 transient transfection assay를 시행하여 세포생존율과 NF-${\kappa}$B의 활성 변동을 측정하였다. 결과 : DU-145 세포에서 봉독을 처리한 후 세포성장이 억제되었으며, 염증관련유전자 발현 및 NF-${\kappa}$B의 활성의 유의한 감소를 나타내었다. DU-145 세포에서 NF-${\kappa}$B의 p50와 IKK들을 치환하여 작용기를 없애고 봉독을 처리하였을 경우에도 세포활성 및 NF-${\kappa}$B의 활성의 유의한 감소를 나타내었다. 결론 : 이상의 결과는 봉독이 NF-${\kappa}$B의 활성 억제를 통하여 인간 전립선암세포주인 DU-145의 세포자멸사를 유발함으로써 증식억제 효과가 있음을 입증한 것으로 전립선암의 예방과 치료에 대한 효과적인 치료제 개발에 도움이 될 것으로 기대된다. 다만 그 기전에서 봉독은 기존연구와 같은 NF-${\kappa}$B p50 및 IKK들의 작용기와 상호작용 이외에 다른 기전이 관여되는 것으로 심화 연구를 요한다.
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경근추나를 중심으로 보존적 치료 후 호전된 요추추간판탈출증 치험례
신정미(Jung Mi Shin),강미숙(Mi Suk Kang),송윤경(Yun Kyung Song) 척추신경추나의학회 2008 척추신경추나의학회지 Vol.3 No.1
This study is designed to evaluate the effect of conservative oriental medical treatment with Kyungkuen Chuna for Herniated intervertebral lumber disc(HIVD) patient. The improvement of the patient was evaluated by Range of Motion(ROM), Straight Leg Rasing Test(SLRT), Visual Analogue Scale(VAS), Oswestry Low-back Pain Disability Index(ODI). After conservative oriental medical treatment with Kyungkuen Chuna, ROM, SLRT, VAS and ODI were significantly improved. It is suggested that Conservative oriental medical treatment with Kyungkuen Chuna could be effective methods to treat the HIVD patient.
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최근 10년간 전침을 관절염에 응용한 연구에 대한 고찰
신정미(Jung Mi Shin),남호문(Ho Moon Nam),정호섭(Ho Sub Jung) 대한스포츠한의학회 2012 대한스포츠한의학회지 Vol.12 No.1
Objectives This study is to research the trend of the treatment of arthritis by electroacupuncture and to establish the hereafter direction for the study on electroacupuncture treatment on arthritis. Methods We reviewed recent 10 years(2002~2011) of english articles that provide full text on pub-med using the keyword electroacupuncture and arthritis . Result We have searched 11 articles. 1. Subjects of study were as follow: The studies on Osteoarthritis were 7, the studies on Rheumatoid arthritis were 3, The study on acute gouty arthritis was 1. 2. For Acupuncture point selection, 8 out of 11 studies used local points, making it more common than distant point selection. 3. The frequency applied was mostly under 10Hz and 2Hz was the most applied frequency. 4. Placebo acupuncture was used for control, but the methods were not consistent. 5. The most frequently adopted evaluation tools were Visual Analogue Scale and Numeric Rating Scale. Conclusion We were able to understand the tendency of electroacupuncture protocol of arthritis over last decade(2002~2011). To establish protocol for electroacupuncture on arthritis, we need more researches about electroacupuncture on arthritis.
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Isoflavonoid의 피부염증균에 대한 항균 및 항산화효과
신정미(Jung Mi Shin),유형원(Hung Won Yu),이현옥(Hyun Ok Lee),이미희(Mi Hee Lee),백승화(Seung Hwa Baek) 大韓藥學會 2006 약학회지 Vol.50 No.1
Puerarin and daidzin have been isolated from Puerariae thunbergiana Benth. Structures were determined by spectroscopic methods. Compounds showed weak antimicrobial activity against S. mutans, S. epidermidis, S. aureus, and C. albicans (MIC, 800㎍/㎖). However, these compounds were not antioxidative. Puerariae thunbergiana Benth. extracts against microorgani는 were evaluated in terms of the minimum inhibitory concentrations (MIC). In general, C. albicans was stronger antimicrobial activity than the other microorgani는. The antioxidative activity of was observed in the etyl acetate extract (IC50, 119.87±0.16㎍/㎖). The DPPH radical scavenging effect (IC50, 1,673.3±0.54μM) of the puerarin was comparable with that of synthetic antioxidant, BHA(IC50, 88.39±1.1)×10-3 μM. These results suggest that puerarin and daidzin have a potential antimicrobial activity.
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정서인식명확성과 분노표현방식 관계에서 분노반추의 매개효과
신정미 ( Jung Mi Shin ),조성호 ( Seong Ho Cho ) 서강대학교 학생생활상담연구소 2014 인간이해 Vol.35 No.1
The purpose of this study was to examine the mediation effects of anger rumination in the relationship between emotional clarity and anger expression attitude. Based on previous studies, anger rumination and anger expression were classified into functional and dysfunctional sub-factors. After analyzing correlations between variables, emotional clarity was found to be statistically positively correlated with functional anger rumination and functional anger expression attitude. Functional anger rumination was also positively related with functional and dysfunctional anger expression. Based on path analysis, functional anger rumination displayed stronger relations with emotional clarity than functional anger expression. Findings of this study identified a possible pathway through which to influence anger expression attitudes, thereby providing useful ideas for counselors who provide intervention services.
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OECD DAC 주요 공여국의 기초교육 공적개발원조 비교 연구
신정미(Shin Jeongmi) 글로벌교육연구학회 2017 글로벌교육연구 Vol.9 No.3
The purpose of this research is to foster advancement of ODA policy in the primary education sector. The study seeks to determine the current status and characteristics of the OECD DAC major donors by analyzing their recent primary education cases from 2010 to 2014 through a detailed literature review that particularly focuses on the scale of ODA, characteristics of recipient countries, main channels of aid, and types of aid. The results of the analysis are as follows: Initially, OECD DAC major donors’ scale of ODA in primary education was generally showing an increasing trend. Additionally, it showed that the larger the scale of ODA in basic education, the greater the yield in educational outcome in primary education. Secondly, the major donors gave the most amount of ODA support in primary education to the least developed countries and to Sub-Saharan Africa, where primary education is urgent. Thirdly, in the aspect of channel of aid, it was clear that NGOs and Civil Society both actively participated in primary education ODA. In the type of aid, meanwhile, there was a tendency to aim a programme-based approach and closer cooperation with multilateral institutions in OECD DAC major donors. This research establishes agendas for Korea’s primary education ODA based on the analysis above. First, Korea needs a discussion over basic education ODA in general. Second, it needs to establish an inclusive strategy to reduce disparity between regions, between countries and between genders. Also, Korea needs to cooperate with leading donor countries and multilateral institutions. In addition, Korea should advance primary education ODA on particularity in education instead of short-term and performance-oriented business. Most of all, the establishment of core values and policy objectives concerning basic education ODA at national level must take precedence in order to improve Korea’s primary education ODA.
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