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분말성제제의 안정성에 관한 연구 : 수종제산제중의 Ascorbic acid 의 안정성 관한 연구
신상철,이민화,우종학 한국약제학회 1973 Journal of Pharmaceutical Investigation Vol.3 No.1
There are many reports on the stability of drugs in powders and tablets. The stabilities of ascorbic acid in the antacid preparations, such as calcium carbonate, magnesium carbonate, magnesium trisilicate, magnesium alumino silicate, and dried aluminum hydroxide gel under various humidities were examined. From the result of the experiment, it was assumed that the concentration of ascorbic acid, the amount of water-vapor sorption, and the physical character of the antacid ingredients were the main factors, influencing the degradation of ascorbic acid. The ascorbic acid, mixed with carbonates, such as calcium carbonate, was degradaded rapidly, while the preparation with dried aluminum hydroxide gel was slightly degraded after 10 days. A 2% ascorbic acid in the prepation was rapidly degraded than 10% ascorbic acid in the preparation.
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