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심포지움,특별강연 및 일반연제 발표 : 신증후군 환자에서 알부민 전처치가 Furosemide 이뇨효과에 미치는 약력학 및 약동학적 유용성 평가
나기영 ( Na Gi Yeong ),김강석 ( Kim Gang Seog ),김연수 ( Kim Yeon Su ),안규리 ( An Gyu Li ),한진석 ( Han Jin Seog ),김성권 ( Kim Seong Gwon ),이정상 ( Lee Jeong Sang ),배균섭 ( Bae Gyun Seob ),신상구 ( Sin Sang Gu ),허우성 ( Heo U 대한신장학회 2000 춘계학술대회 초록집 Vol.19 No.2
간경변증 환자에서 Ranitidine 의 약동학적 연구
이동호,윤세진,엄재호,장인진,진영주,신상구 대한소화기학회 1999 대한소화기학회지 Vol.32 No.5
Background/Aims: Approximately 50% of ranitidine is eliminated by hepatic metabolism, but the pharmacokinetics of ranitidine in patients with liver cirrhosis (LC) are poorly documented. This study was conducted to investigate the pharmacokinetic changes of ranitidine in patients with LC and to evaluate the possible contribution of the kinetic changes to the adverse CNS (central nercous system) effects of ranitiidine in patients with liver disease. Methods: The pharmacokinetics of single-dose ranitidine were studied in 12 patients with LC and 8 controls. After 150 mg of ranitidine was given by mouth, blood samples were collected at 1, 2, 3, 4, 5, 6, 8, 12 hours, and urine was also collected for 12 hours, Serum and urine concentrations of ranitidine were determined by HPLC method and the nizatidine was used as internal standard. Results: In patients with LC, AUC (area under curve) was significantly increased (p$lt;0.05) and total clearance rate was significantly decreased (p$lt;0.05). Renal clearance was significantly decreased (p$lt;0.05) and half-life was significantly prolonged (p$lt;0.05). Effective serum concentration was maintained more prolongedly. Conclusions: These pharmacoki- netic changes which were attributed to increase of bioavailability and decrease of renal clearance, may contribute partly to the adverse CNS reactions of ranitidine in patients with hepatic dysfunction. Therefore, the adjustment of ranitidine dose should be considered in patients with severe hepatic dysfunction.