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신국현,강삼식,지형준,Shin, Kuk-Hyun,Kang, Sam-Sik,Chi, Hyung-Joon 한국생약학회 1992 생약학회지 Vol.23 No.1
A new method for the analysis of coumarin constituents in the roots of Peucedanum japonicum by high performance liquid chromatography was established. Among two coumarin constituents identified, peucedanol was confirmed to be applicable to a standard compound. A reversed phase system with a ${\mu}Bondapak$ C_{18}$, column using $H_2O-MeOH=5\;:\;4$ as a moble phase was developed. Peucedanol and a minor constituent, umbelliferone were detected at 333nm and the analysis was successfully carried out within 20 min.
신국현,이은방,송영진,김운자,Shin, Kuk-Hyun,Lee, Eun-Bang,Song, Young-Jin,Kim, Oon-Ja 한국생약학회 1992 생약학회지 Vol.23 No.3
The deodorizing responses of the steam distillate from some medicinal plants(G-3) on three representative malodors were evaluated by estimating the best estimate threshold(BET) of odor responses. With a single spray of G-3, the BETs of malodors such as ammonia, acetic acid, and ethyl acetate were found to increase 4.11, 32.6 and 13.1 fold, respectively, which indicated G-3 possessed a potent deodorizing activity. The deodorizing potency of G-3 was also demonstrated to be as high as and even higher than those of the commercial deodorizing agents.
아출(莪朮)의 Sesquiterpene 성분의 약물활성
신국현,윤기영,조태순,Shin, Kuk-Hyun,Yoon, Ki-Young,Cho, Tae-Soon 한국생약학회 1994 생약학회지 Vol.25 No.3
Pharmacological activities of two sesquiterpenes, curzerenone(I), and curcumenol(II) isolated from the rhizomes of Curcuma zedoaria being used as an aromatic stomachic in Chinese medicines were evaluated in rats and mice. Curzerenone (I), at 100mg/kg, p.o. showed a potent protective effect against HCl-ethanol induced gastric lesion in rats, and curcumenol(II), at the same dose level showed a CNS depressant action characterized by a potentiation of hexobarbital(HB)-induced narcosis. Both compounds showed a moderate analgesic action but did not exhibit a hypothermic action even at 200mg/kg dose level.
수종 생약 수증기 증류물이 유기인제 농약에 의하여 저해된 Acetylcholinesterase 활성에 미치는 효과
신국현,이은방,송영진,김운자,Shin, Kuk-Hyun,Lee, Eun-Bang,Song, Young-Jin,Kim, Oon-Ja 한국생약학회 1992 생약학회지 Vol.23 No.2
The acute toxicity and the effect of steam distillate obtained from several plant mixtures (G-3) on the reactivation of brain, lung, and blood acetylcholinesterase (AChE) activity, and recovery from other toxic symptoms following intoxication by organophosphate pesticides were investigated in mice and mudfish. Administration of G-3 $(50{\sim}100\;ml/kg,\;i.p.)$ immediately or 30 min prior to Diazinon or Sumithion treatments, respectively, resulted in a significant reactivation of AChE activity in brain, lung, and blood, their potencies being almost equipotent to those of 2-PAM, one of well-known antidotes. G-3 itself exhibited almost no acute toxicity even at the highest dose employed, and without effect on the inhibition of hepatic drug metabolism function following organophosphate administrations. G-3 showed a significant diminution of the death rate in mudfish as well as in mice intoxicated by Diazinon.
Piperine 이 간 Micorosmal Mixed Funtion Oxidese system 에 미치는 영향
신국현,우원식 ( Kuk Hyun Shin,Won Sick Woo ) 생화학분자생물학회 1985 BMB Reports Vol.18 No.1
The effect of piperine on hepatic microsomal mixed function oxidases (MFO) was investigated. Piperine, on repeated daily administrations (100㎎/㎏, p.o. for 7 days) to mice, shortened markedly the duration of hexobarbital induced narcosis (72%) and increased aminopyrine N-demethylase (112.7%) and hexobarbital hydroxylase (78.5%) as well as in the level of cytochrome p-450 (154.2%). At pharmacologically effective doses, it did not affect MFO in vivo, whereas, it produced an inhibition of both aminopyrine and hexobarbital metabolism at a high dose (100 ㎎/㎏, i.p.). Kinetic studies on rat hepatic microsomal enzymes, in vitro, have shown that piperine gave a type I difference spectrum (max. 385㎚, min. 422 ㎚) and appeared to be a competitive inhibitor of aminopyrine N-demethylase and mixed type inhibitor of hexobarbital hydroxylase, the apparent inhibition constants (Ki) of which being 0.128 mM and 0.098 mM, respectively.
육두구 종자성분 Phenylpropanoid 들의 간 MFO 억제 및 유도효과
신국현,우원식 ( Kuk Hyun Shin,Won Sick Woo ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.1
The effects of phenylpropanoids, myristicin(I), licarin-B(II), dehydrodiisoeugenol (III), 2-(4-allyl-2,6-dimethoxyphenyl)-1,4-hydroxy-3-methoxyphenylpropanol-l-ol(IV), isolated from the seeds of Myristica fragrans on hepatic microsomal mixed function oxidase (MFO) were investigated. All four compounds, with a single administration (200㎎/㎏, i.p.) in mice, caused not only a significant prolongation of hexobarbital (HB)-induced hypnosis but also a significant reduction in activities of aminopyrine N-demethylase and hexobarbital hydroxylase. Compound I was observed to bind to phenobarbital-induced cytochrome P-450 to give a type I binding spectrum whereas compound III and IV gave a reverse type I difference spectrum. On repeated administration, compound I, II and III caused a shortening of the duration of hypnosis as well as increases in hepatic enzyme activities. Compound I and II provoked a sleep episode at a subhypnotic dose of HB, suggesting that they possess CNS depressant properties.
Antiinflammatory Action of Phytolaccosides
신국현(Kuk Hyun Shin),우원식(Won Sick Woo),이정규(Chung Kyu Lee) 한국생약학회 1979 생약학회지 Vol.10 No.2
Antiiflammatory action of phytolaccosides B and E isolated from the roots of Phytolacca americana was investigated and compared with that of aescin. Phytolaccoside B, when it was administered intravenously, exerted a potent inhibitory effect on the transudation caused by absorptive sponge pellet implanted s.c. in rats and on carrageenin induced edema in rats. Phytolaccoside E showed a weaker action than Phytolaccoside B did. Hemolytic potency of the saponins was decreased in the order of aescin, phytolaccosides B and E showing a same tendency as in antiinflammatory action. The experimental result suggests that the mode of action of phytolaccosides is the same as that of aescin.
신국현(Kuk Hyun Shin),지형준(Hyung Joon Chi) 한국생약학회 1979 생약학회지 Vol.10 No.1
The naturally occurring coumarins are likely to be a large and important group of plant products which are not only metabolic products of the living cells but possess varied physiological and pharmacological actions. Investigations concerning various biological activities of natural coumarins have been undertaken by many investigators in continuing effort. The authors describe on experimental results of biological activities of coumarin derivatives with particular emphasis on 10 different activities that are considered to be of importance in view of the development of new drugs from natural resources.