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도립(-6°)이 혈장 Catecholamine 및 심장혈관계에 미치는 영향
송대규(Song, Dae-Kyu),배재훈(Bae, Jae-Hoon),박원균(Park, Won-Kyun),채의업(Chae, E-Up) 대한생리학회 1987 대한생리학회지 Vol.21 No.2
Head-down tilt (HDT) at -6˚ has been commonly used as the experimental model in both man and animals to induce the blood shift toward the head or central protion of the body, demonstrating similar physiological effect encountered in the weightlessness in the orbital flight. There are few reports about the physiological response upon the cardiovascular regulatory system or the tolerance to the (-6˚) HDT within a relatively short period less than 1 hour. Therefore, the purpose of this study way to observe the effects of -6˚ HDT on cardiovascular system within 30 minutes and to evaluate early regulatory mechanism for simulated hypogravity. Ten mongrel dogs weighing 8-12 kg were anesthetized with the infusion of 1% α-chloralose (100 mg/kg) intravenously, and the postural changes were performed from the supine to the -6˚ head-down Position, then from the head-down to the supine (SUP), and each posture was maintained for 30 minutes. Blood flow (Q̇) through common carotid and femoral arteries were determined by the electromagnetic flowmeter. Mean arterial pressure (MAP), heart rate (HR), respiratory rate , and pH, Po<sub>2</sub>, Pco<sub>2</sub> and hematocrit (Hct) of arterial and venous blood were also measured. The peripheral vascular resistance was calculated by dividing respective MAP values by Q̇ through both sides of common carotid or femoral arteries. The concentration of plasma epinephrine and norepinephrine was determined by Peuler & Johnson s radioenzymatic method. The results are summarized as follows: In the initial 5 minutes in -6˚ HDT, HR was significantly (p<0.05) increased and MAP slightly decreased. Although Q̇ and carotid peripheral artery resistance were not significantly changed, Q̇ through femoral artery was diminished and femoral peripheral artery resistance was elevated. In the SUP, the initial changes of MAP and HR were increased (p<0.05), but those of Q̇ and peripheral vascular resistance through both common carotid and femoral arteries were not significant. After 10 minutes of each postural change in both HDT and SUP, MAP was maintained almost equal to that of the level of pretilting control. During 60 minutes of both postural changes of HDT and SUP, Po<sub>2</sub> and Hct were not changed significantly. However pH tended to increase slowly and Pco<sub>2</sub> was gradually decreased. The pH and Pco<sub>2</sub> seemed to be related to the increased respiratory rate. Plasma epinephrine concentration was not changed significantly and plasma norepinephrine concentration was slightly decreased in the course of HDT and also at 10 minutes of SUP. However these concentration changes were statistically insignificant. From these results, it may be concluded that the effect of -6˚ HDT for 30 minutes on the cardiovascular system and plasma catecholamine levels of the dog is minimum and it is suggestive that the cardiovascular regulatory mechanism, possibly mediated by so called gravity receptors including baroreceptor and volume receptor, has been properly and adequately operated.
생쥐에서 전기자극 스트레스에 의한 행동반응과 면역 기능 변화
김정범,박원균,송대규,Kim, Jung-Bum,Park, Won-Kyun,Song, Dae-Kyu 한국정신신체의학회 1996 정신신체의학 Vol.4 No.1
The present experiment was designed to investigate the effects of behavioral, response to immune function in response to electric footshock in mice. Mice were subjected to electric footshock for 3 days(two sessions a day, 11 times of shock for about 31 minutes a session). The humoral immune response was measured using mice immunized with rat RBC. The cell-mediated immune responses were evaluated by contact hypersensitivity to 2, 4-dinitrofluorobenzene(DNFB) and by phytohemagglutin(PHA)-stimulated splenocytes proliferation assay. In stressed group, electric footshock suppressed significantly anti-rat RBC antibody production(p<0.05), but enhanced significantly $T_{48}$ relative to $T_{24}$ in contact hypersenstivry (P<.01) and T-cell proliferation response(P<.05) by PHA stimulation elative to control group. T-cell proliferation response by PHA stimulation was significantly correlated to the movement than the sensitivity and coping behavior in the mouse, in response to the electric footshock. These data supper the importance of behavioral response in stress-induced changes of immune functions.
대뇌 기저핵 신경세포에서 Nitric Oxide를 매개로 한 망간의 세포독성
정용욱,배재훈,송대규,박원균,고복현,김두희,신동훈,Jung, Yong-Wook,Bae, Jae-Hoon,Song, Dae-Kyu,Park, Won-Kyun,Ko, Bok-Hyun,Kim, Doo-Hie,Shin, Dong-Hoon 대한예방의학회 1999 예방의학회지 Vol.32 No.4
Objectives:eurotoxicity is mediated by nitric oxide(NO) in the rat primary neuronal cultures and assess the effect of $Mn^{2+}$ on the N-methyl-D aspartate(NMDA) receptors. Methods: We have used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)assay to examine the effect of cytotoxicity of $MnCl_2$ in neuronal cells , NO production was determined by measuring nirites, a stable oxidation product of NO. The neurons in the rat that contains neuronal nitric oxide synthase(nNOS) were examined by immunofluorescence and confocal microscopy. The effects of $Mn^{2+}$ on the NMDA receptors was assesed by the whole cell voltage clamp technique. Results: We showed that the NO release and NOS expression was increased with 500uM $MnCl_2$ treatment and an NOS inhibitors, $N^G-nitro-L-arginine$, prevented neurotoxicity elicited by manganese. In the electrophysiological study, $Mn^{2+}$ does not block or activate the NMDA receptors and not pass through the NMDA receptors in a neurons of basal ganglia. Conclusions: It is concluded that manganese neurotoxicity in basal ganglia was partially mediated by nitric oxide in the cell culture model.