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光週期가 Ground Cricket 2종의 卵發育에 미치는 影響
宋基德 고신대학교 자연과학연구소 1994 고신대학교 자연과학연구소 논문집 Vol.4 No.-
In order to elucidate the correlation between phoperiodic response and developmental period, the eggs were stored in the refrigerator at 6℃ and then transferred 26℃ at various photoperiod. Photoperiodic conditiond were set in five separate series. The eggs of Pteronembious taprobanensis of Cheju hatched out in 78.36 days and that of Anyang did in 43.35 days at 11L:13D. The eggs of P. fascipes of Cheju hatched out in 41.35 days and that of Anyang in 85.72 days at 14L:10D.
Current Progress in Generation of Genetically Modified Mice
송기덕,조병욱,Song, Ki-Duk,Cho, Byung-Wook Korean Society of Life Science 2007 생명과학회지 Vol.17 No.4
Manipulation of the mouse genome by activating or inactivating the gene has contributed to the understanding of the function of the gene in the subset of cells during embryonic development or postnatal period of life. Most of all, gene targeting, which largely depends on the availability of mouse embryonic stem (ES) cells, is the milestone of development of animal models for human disease. Recombinase-mediated genome modification (Cre-LoxP and Flp-Frt etc) and the ligand-dependent regulation system, more accurate and elaborate manipulation tools, have been successfully developed and applied to dissect the mechanisms governing complex biological processes and to understand the role of protein in temporal-and spatial aspects of development. As technologies concerning refined manipulation of mouse genome are developed, they are expected to open new opportunities to better understand the diverse in vivo functions of genes. 생쥐 유전자를 과발현 시키거나 제거하는 유전자 조작 기술의 발달은 배 발생 단계나 출생 후 특정한 세포에서의 특정 단계에서의 유전자 기능을 이해하는 많은 기여를 하고 있다. 특히, 높은 상동 재조합 활성을 가지는 생쥐 배 줄기세포를 이용한 유전자 적중 기법은 인간 질환을 이해하는데 필수적인 동물 모델 개발에 중요한 기여를 하였다. 최근에는 Cre과 Flp와 같은 염기서열 특이적 재조합 효소와 라이겐드에 의한 조절 시스템의 도입으로 좀 더 정확하고 정교한 유전자 발현 조절을 위해 개발되어 복잡한 생명현상을 지배하는 메카니즘과 시간과 공간에서 작동하는 유전자의 기능을 이해하는데 많은 기여를 하고 있다. 마우스 게놈을 세밀하게 조작할 수 있는 새로운 분자생물학적 도구의 적용으로 in vivo상에서 유전자의 다양한 기능을 좀 더 정확하게 이해할 수 있는 기회가 열릴 것으로 기대된다.
T Cell Receptor Signaling That Regulates the Development of Intrathymic Natural Regulatory T Cells
송기덕,윤철희,황수진 대한면역학회 2011 Immune Network Vol.11 No.6
T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus,quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to positive and negative selection. Recently, it has been suggested that self-reactive T cells, escape from negative selection,should be suppressed in the periphery by regulatory T cells (Tregs) expressing Foxp3 transcription factor. Foxp3 is a master factor that is critical for not only development and survival but also suppressive activity of Treg. However, signals that determine Treg fate are not completely understood. The availability of mutant mice which harbor mutations in TCR signaling mediators will certainly allow to delineate signaling events that control intrathymic (natural) Treg (nTreg)development. Thus, we summarize the recent progress on the role of TCR signaling cascade components in nTreg development from the studies with murine model.