http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
송관규 대한류마티스 건강전문학회 1997 근관절건강학회지 Vol.4 No.2
Chronic fatigue syndrome is a syndrome of unknown etiology and pathophysiology characterized by severe, chronic, debilitating fatigue as main symptom and numerous additional symptoms such as joint and muscle pain, headache, sleep disturbance. According to recent researches, it was suggested that chronic fatigue syndrome was developed by disturbance of interaction between neuropsychiatric system and immune system due to environmental factors and stress. Many patients experience gradual improvement but complete recovery from disorderd state is rare. There was no research elucidating the exact pathogenetic mechanism of chronic fatigue syndrome, so there was no established treatment. Several controlled studies about treatment was reported , but its results was not effective in all patients with chronic fatigue syndrome. For chronic fatigue syndrome, a comprehensive approach to physical, psychological, and social aspects is needed.
경피증 환자의 폐섬유화에 대한 cyclophosphamide 강압 요법과 소량의 부신피질 호르몬을 경구투여한 병합 요법의 효과에 관한 연구
송관규 ( Gwan Gyu Song ),이영호 ( Young Ho Lee ),심재정 ( Jae Jeong Shim ),강경호 ( Kyung Ho Kang ) 대한류마티스학회 1996 대한류마티스학회지 Vol.3 No.2
Objective: To investigate the efficacy of combined intravenous cyclophophamide pulse and low dose oral prednisolone treatment in patients with systemic sclerosis with interstitial lung disease. Method: Six patients with systemic sclerosis with interstitial lung disease were treated with intravenous infusion of cyclophosphamide (0.75g/m2 body surface area) and low dose oral prednisolone (10mg/day). Results: 1) Respiratory symptoms, cough and dyspnea, were improved in all patients in both frequency and severity. 2) The mean value of FVC, FEVl, and DLCO test showed tendency of increase during the follow up period (upto 24 months) compared to decrease in the past studies. 3) There was no serious side effect during the trreatment. Herpes zoster was developede in 1 patient during treament. Conclusions: Combined intravenous cyclophosphamide pulse and low dose oral prednisolone treatment is effective for the patients with systemic sclerosis with interstitial lung disease. A controlled prospective trial is warranted in patients with systemic sclerosis with interstitial lung disease.
전신성 홍반성 낭창 환자에서 유리형 Fas 단백질에 대한 연구
송관규 ( Gwan Gyu Song ),이영호 ( Young Ho Lee ) 대한류마티스학회 1996 대한류마티스학회지 Vol.3 No.1
Objective: To investigate soluble Fas(sFas) protein in the sera of patients with systemic lupus erythematosus (SLE). Methods: sFas protein was measured by sandwich ELISA method in the sera of 30 patients with SLE (mean age: 27.4±8.46, F:M=29:1) and 11 patients with fibromyalgia (mean age 35.8±11.5, F:M-11:0) as a control group. Results: sFas was elevated in 6 (20%) patients of SLE and 1 (9%) of patients with fibromyalgia (p=0.41). sFas level was correlated with a shorter duration, lower dosage of systemic steroid and higher disease activity in patients with elevated sFas levlel compared to patients with normal serum levels of sFas. All patients with elevated sFas had been diagnosed with SLE for less than 1 month. Fifty % (6 out of 12) patients with SLE for less than 1 month showed elevated sFas in serum. There was no difference of in the age between patients with elevated and normal levels of sFas. Conclusion: These data indicate that elevated sera levels of sFas was associated with the early active phase of disease in some patients with SLE and may play a role in defective apoptosis.
배양된 연골세포에서 각종 Cytokine과 성장인자가 β1-integrin 및 ICAM-1의 발현에 미치는 영향
송관규 ( Gwan Gyu Song ),노영무 ( Young Moo Ro ),유대현 ( Dae Hyu Yoo ),김성윤 ( Seong Yoon Kim ) 대한류마티스학회 1995 대한류마티스학회지 Vol.2 No.1
Objective: The cell-cell and cell-extracellular matrix interactions are critical to the embryogenesis, morphogenesis, maintenance of tissue integrity, and function of cells. This interactions are mediated by membrane glycoproteins called adhesion molecules. βl-integrins are heterodimeric transmembrane glycopro-teins which play critical roles in the ability of cells to elaborate and maintain extracellular matrix. ICAM-l is a sialylated glycoprotein and mediates various cell-cell interactions in immunity and inflammation. Articular cartilage consists of chondrocytes embedded in an extensive extracellular matirx. In normal tissue, the chondrocytes actively effect the stable equili-brium between the synthesis and degradation of matrix components, so that a constant concentration of these components is maintained. In osteoarthritis, the stable equilibrium is disrupted and the rate of loss of proteoglycan exceeds the rate of depositon of newly synthesized moleclues. This equilibrium is influenced by cytokines and growth factors such as IL-I, TNF-α, IGF-1 and TGF-β. Integrins and their ligands may mediate some of the interactions of chondrocytes and cellular matrix, and the cytokines and local growth factors may affect the expression of integrins on chondrocytes. ICAM-1 may mediate interactions with other cells in osteoarthritic joint, and also may be modulated by cytokines and growth factors. The effect of IL-I, TNF-α, IGF-1 and TGF-β in the expression of, β1-integrin (CD29) and ICAM-1(CD54) on chondrocytes was investigated. Methods: Cultured chondrocytes(3rd passages) from 2 osteoarthritc patient were used. Cells were incubated for 24hours with and without IL-1β 25U/ml, IL-l 50U/ml, TNF-α 1ng/ml, TNF-α 10ng/ml, IFN-γ 100U/ml, IGF-1 10ng/ml, IGF-1 50ng/ml, IGF-1 100ng/ml, TGF-β 10ng/ml, and TGF-β 30ng/ml. Chondrocytes were stained with monoclonal antibodies against, β1-integrin (CD29) and ICAM-1 (CD54), and positve cells were counted under the light microscpe. Results: 1) Cultured chondrocytes readily expressed, β1-integrin (82.9%). 2) β1-integrin was down-regulated by IL-1β(75.4%), TNF-α(61.2%), and TGF-β (77.0%), and was slightly up-regulated by IFN-γ(85.0%) and IGF-1 (88.9%). 3) ICAM-1 was presented in only 18.0% of cells. 4) Expression of ICAM-1 was readily up-regulated by IL-1β(84.0%) and TNF-α(80.3%), and mildly up-regulated by IFN-γ(33.0%), IGF-1(35.0%), and TGF-β(29.3%). Conclusions: The presence of, 81-integrin and ICAM-1 on chondrocytes and the modulation of their expression by cytokines and local growth factors suggest that they have important roles in the interaction of chondrocytes with cartilage matrix and with other cells of osteoarthritic joints. Their roles should be elucidated by further researches.