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손진욱 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.4
King Saul in the Old Testament was described as having a depressive syndrome in textbooks of psychiatry. The author investigated the psychopathlology of King Saul from the record of 1 Samuel in the Old Testament. It seemed that Saul had the characteristic psychopathology and primitive defense of borderline personality disorder, in addition to some features of depression and schizotypal personality disorder. In conclusion, the author thought that Saul might be a patient of borderline personality disorder associated with depressive syndrome and/or schizotypal personality disorder.
손진욱,Sohn, Jin-Wook 대한수면의학회 1995 수면·정신생리 Vol.2 No.2
The author reviews current knowledge about what REM sleep is and where and how it is generated. REM sleep is the state in which our most vivid dreams occur. REM sleep is identified by the simultaneous presence of a desynchronized cortical EEG, an absence of activity in the antigravity muscles(atonia), and periodic bursts of rapid eye movements. Another characteristic phenomena of REM sleep are the highly synchronized hippocampal EEG of theta frequency and the ponto-geniculo-occipital(PGO) spike. All these phenomena can be explained in terms of changes in neuronal activity. Transection studies have determined that the pons is sufficient for generating REM sleep. Lesion studies have identified a small region in the lateral pontine tegmentum corresponding to lateral portions of the nucleus reticularis pontis oralis(RPO) and the region immediately ventral to the locus coeruleus, which is required for REM sleep. Unit recording studies have found a population of cells within this region that is selectively active in REM sleep. Cholinergic neurons of the giant cell field of pontine tegmentum(ETG), which is 'REM a sleep-on cells', has shown to be critically involved in the generation of REM sleep. Noradrenergic neurons of the locus coeruleus and serotonergic neurons of the dorsal raphe, which are called 'REM sleep-off cells', appear to act in a reciprocal manner to the cholinergic neurons. It is proposed that the periodic cessations of discharge of 'REM sleep-off cells' during REM sleep might be significant for the prevention of the desensitization of receptors of these neurons.
일개(一個) 대학병원(大學病院) 초입원환자(初入院患者)의 불면증(不眠症) 유병률(有病率), 원인(原因) 및 약물처방(藥物處方)에 관한 연구(硏究)
손진욱,이태우,Sohn, Jin-Wook,Lee, Tae-Woo 대한수면의학회 1997 수면·정신생리 Vol.4 No.1
The purpose of this study was to investigate the prevalence, primary causes, and management of insomnia newly admitted patients in a university hospital. Subjects consisted of 168 adult patients (95 men and 73 women, 88 medical and 94 surgical patients) newly admitted to Gyeongsang National University Hospital from September 7 through September 27, 1996. Sleep patterns of all subjects in the usual nights before admission(UN), the previous night to admission(PN), the night on admission(ON), and the 5th night after admission(5N) were investigated using the Korean version of the St. Mary's Hospital Sleep Questionaire. In addition, all insomnia patients and their doctors and nurses in charge were interviewed by psychiatric residents. Additionally, their medical records were reviewed. Prevalence of insomnia were 22.6% in the UN, 42.9% in PN, 51.8% in ON, and 43.5% in 5N. The prevalence of insomnia was significantly increased immediately before and after admission. There were no significant differences in the prevalence of insomnia by age and sex. The most ammon primary causes of insomnia were somatic symptoms and psychological factors in PN, somatic symptoms and noise in ON and 5n. Only 17 (10.1%) of insomnia patients took medicstions for insomnia control(analgesics in 15, hypnotics in 2). These results shorred that the prevalence of insomnia was significantly increased on hospitalization due to somatic symptoms, environmental factors, and psychological factors, but nearly none were adequately managed.
전기경련충격이 흰쥐 뇌의 Glutamine Synthetase의 활성도에 미치는 영향에 관한 연구
손진욱 大韓神經精神醫學會 1990 신경정신의학 Vol.29 No.3
In order to elucidate the machanism of action of electroconvulsive shock (ECS) in psy-chiatric illness, the author investigated the effect of electroshock on glutamine synthetase (GS) in rat brain. GS activities in hippocampus, corpus striatum and cerebral cortex were measured after single, multiple and regressive electroshocks (subconvulsive and convulsive doses) to nor-mal rats, and GS activities were also measured after ECS in methionine sulfoximine trea-ted rats. Major findings were that ten daily ECS (multiple ECS) decreased GS activities in the hippocampus and four ECS in 30 min interval (regressive ECS) reinforced the GS inhibi-tion of methionine sulfoximine. These findings suggest that GS may play a signifncant role in the mechanism of action of ECS and need further studies.