Hepatitis B virus X Protein Promotes Liver Cancer Progression through Autophagy Induction in Response to TLR4 Stimulation

손주희,김미정,이지수,김지영,전은영,이기영 대한면역학회 2021 Immune Network Vol.21 No.5

Hepatitis B virus X (HBx) protein has been reported as a key protein regulating the pathogenesis of HBV-induced hepatocellular carcinoma (HCC). Recent evidence has shown that HBx is implicated in the activation of autophagy in hepatic cells. Nevertheless, the precise molecular and cellular mechanism by which HBx induces autophagy is still controversial. Herein, we investigated the molecular and cellular mechanism by which HBx is involved in the TRAF6-BECN1-Bcl-2 signaling for the regulation of autophagy in response to TLR4 stimulation, therefore influencing the HCC progression. HBx interacts with BECN1 (Beclin 1) and inhibits the association of the BECN1-Bcl-2 complex, which is known to prevent the assembly of the pre-autophagosomal structure. Furthermore, HBx enhances the interaction between VPS34 and TRAF6-BECN1 complex, increases the ubiquitination of BECN1, and subsequently enhances autophagy induction in response to LPS stimulation. To verify the functional role of HBx in liver cancer progression, we utilized different HCC cell lines, HepG2, SK-Hep-1, and SNU-761. HBx-expressing HepG2 cells exhibited enhanced cell migration, invasion, and cell mobility in response to LPS stimulation compared to those of control HepG2 cells. These results were consistently observed in HBx-expressed SK-Hep-1 and HBx-expressed SNU-761 cells. Taken together, our findings suggest that HBx positively regulates the induction of autophagy through the inhibition of the BECN1-Bcl-2 complex and enhancement of the TRAF6-BECN1-VPS34 complex, leading to enhance liver cancer migration and invasion.

旣成服 選擇 要領

孫珠熙 농촌진흥청 1991 농촌생활과학 Vol.12 No.4

직소(Jigsaw) 모형을 활용한 한국어 읽기 교육 연구

손주희 한국 리터러시 학회 2023 리터러시 연구 Vol.14 No.2

The purpose of this study is to explore the possibility of teaching-learning and verify its effectiveness by applying the Jigsaw model as a new method of Korean reading education. The Jigsaw IV model was modified to design a step-by-step procedure applied to Korean reading education. It consisted of six stages: the introduction stage, the original group stage, the expert group stage, the original group stage, the evaluation stage, and the feedback stage. In order to experiment on the experience and effectiveness of Jigsaw activities, the fourth week of classes was conducted on 35 Chinese and Japanese. In order to confirm the results of the experiment, data were collected by conducting surveys and interviews. As a result of the analysis, learners’ explanatory ability, understanding, and concentration increased. It also works for interaction and problem-solving skills. Learning motivation and interest have increased, and anxiety about learning can be resolved. In addition, Korean language skills were further improved by adding various activities through classes linked to other areas. Through this study, it will be an example of confirming that the Jigsaw model is an effective and applicable teaching-learning technique for Korean reading classes. 본 연구는 한국어 읽기 교육의 새로운 방법으로 직소(Jigsaw) 모형을 적용하여 한국어 읽기 교수-학습의 가능성을 탐색하고 그 효과를 검증하는 것을 목적으로 한다. 이를 위해 직소Ⅳ 모형을 수정하여 한국어 읽기 교육에 적용한 단계별 절차를 설계하였다.도입 단계,원래 모둠 단계,전문가 모둠 단계,원래 모둠 단계,평가 단계,피드백 단계의 6단계로 구성하였다. 직소 활동 경험과 효과에 대한 실험을 위해 35명의 중국인과 일본인을 대상으로4주차 수업을 진행하였다.실험의 결과를 확인하기 위해 설문조사와 인터뷰를 진행하여 자료를 수집하였다.분석 결과,학습자들의 설명 능력,이해력,집중력이 상승하였으며,상호작용능력과 문제 해결 능력에도 효과적인 것을 확인하였다.그리고 학습 동기와 흥미 상승,학습에 대한 불안감을 해소,연계 수업을 통한 전반적인 한국어 능력신장의 효과를 얻었다. 본 연구를 통해 직소 모형은 한국어 읽기 수업에 효과적이며 적용 가능한 교수-학습 기법이라는 것을 확인하는 사례가 될 것이다.

이그나시 몬레알(Ignasi Monreal)의 패션 일러스트레이션에 나타나는 초현실주의적 특성 -2018 S/S Gucci Hallucination 컬렉션을 중심으로-

손주희,전재훈 한국의류학회 2022 한국의류학회지 Vol.46 No.3

Fashion illustration is a language that expresses the inspirational imagination of designers. Like fashion, illustration reflects and records the social and cultural phenomena of the time. In this context, Ignasi Monreal's fashion illustration shows the characteristics that reveal modern people's ways of thinking and their desires. This study analyzed work by Ignasi Monreal in ‘Gucci Hallucination’ of 2018 S/S to examine the characteristics of his new painting style and the messages his fashion illustration aims to convey. He tried to harmonize his surrealistic digital illustrations of Greek mythology with Gucci items. As a result of this study, the characteristics of Monreal's illustration works were divided into two main categories: formal aspects (similarity of composition or subject and use of dépaysement techniques), and content aspects (expression of a mythical surreal being). These qualities differentiate Monreal's fashion illustration from that of other artists. In addition, his works on the myth of Icarus not only express the desires of modern people but also convey social satirical messages.

HSDPA 시스템에서 요금 기반의 패킷 스케줄링 알고리즘에 관한 연구

손주희,박세권,박용완,이경락,장재성,문순주,Son Ju-Hee,Piao Shi-Quan,Park Yong-Wan,Lee Kyong-Lak,Chang Jae-Sung,Moon Soon-Joo 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.3C

본 논문에서는 이동통신사업자가 서비스 종류에 따라 서로 다른 트래픽 요금기준을 적용하는 점을 이용하여 시스템에서의 전체적인 요금을 최대화하는 패킷 스케줄링 알고리즘을 제안한다. 제안하는 알고리즘은 스케줄링되는 각 사용자의 채널상태를 나타내는 SIR(signal to interference ratio)값과 각 사용자가 요청하는 서비스 종류에 근거하여 각 사용자의 요금 함수치를 산출하여 스케줄링한다. 제안하는 알고리즘의 성능을 측정하기 위하여 HSDPA 시스템에서 Max C/I, 비례공정 알고리즘, 라운드 로빈 알고리즘과 비교 분석한다. 성능 비교분석 결과 제안하는 알고리즘이 우수한 수율(throughput)을 유지하면서 이동통신 사업자의 수익(revenue)도 최대화됨을 보여준다. In this paper, we propose a packet scheduling algorithm to maximize the required total price of the systems that is applied with a different traffic pricing criterion by the mobile service operator according to different kinds of the services. The proposed algorithm adopts a particular estimation method in scheduling using the value of pricing function, which is based on the required services and the value of SIR(signal to interference ratio) that indicate the channel condition of each user. We compare Max C/I, proportional fairness and round robin algorithm with the proposed algorithm on HSDPA in order to analyze the performance. The result shows that the proposed algorithm satisfies higher throughput and provides maximum the mobile service provider's revenue.

청주시 제2 쓰레기매립장 입지 갈등사례

손주희 한국갈등학회 2017 한국갈등학회보 Vol.3 No.1

북한 통계부문의 지속가능한 협력방안 모색: 북한중앙통계국과 UN의 협력사례를 중심으로

손주희 서울대학교 국제학연구소 2021 국제지역연구 Vol.30 No.3

North Korea has affirmed its commitment to the implementation of the UN SDGs goals and targets. North Korea has strategically incorporated the UN SDGs into its national development strategies and established its own SDGs goals and indicators accordingly. In 2018, North Korea organized a national SDG Implementation Task Force under its cabinet. The chairman and vice chairman of the Task Force are the Vice Prime Minister and the Director of the Central Bureau of Statistics, respectively. In North Korea’s SDGs implementation process, the Central Bureau of Statistics(CBS) plays a leading role in collecting and evaluating SDGs data reported from ministries and agencies at both central and local levels. Yet, North Korea has faced many issues in both producing and monitoring the SDGs data mainly due to the lack of statistical capacity and the limitation on which most of those statistics produced by North Korea are not internationally comparative. Responding to North Korea’s request for help, a various UN agencies have provided technical assistance and trainings to the CBS officials over the past decade. This study examined those cooperative programmes in the field of health, social and economic statistics provided by WFP/UNICEF/WHO, UNFPA and UNESCAP, respectively. Overall, such statistical cooperation have led to many positive results. The CBS officials have obtained new technology and knowledge required to produce SDGs statistics in accordance to international standards and methodology. It is also worth noting that the CBS officials have received capacity trainnings on SNA from UNESCAP since 2013. This might mean that North Korea is considering to adopt the UN-recommended SNA from its current version of soviet-style MPS system. When designing the future cooperative plans especially funded by the Korean government, a direct participation of Korea institutions could be considered since statistical cooperation is apolitical and tends to be less susceptible to UN sanctions. 북한은 2021년 7월 13일에 개최된 유엔경제이사회 산하의 고위급 정치포럼에서 최초로 자발적 국별리뷰(Voluntary National Review: VNR)를 제출하여 자국의 SDGs 17개 목표와 95개 세부목표, 132개 이행지표와 그 이행현황을 보고하였으며, 자국의 SDGs 이행에서의 중앙통계국의 역할과 통계역량강화의 중요성을 역설하였다. 이와 관련하여 본고에서는 ‘지속가능한발전목표(Sustainable Development Goals)’ 측면에서 북한과 통계협력을 지속하기 위해서는 북한에 대한 UN의 기술지원 및 역량강화 훈련방식을 활용하는 것이 가장 효율적이라는 점을 제시하고자 한다. 이를 살펴보기 위해 본고에서는 북한중앙통계국이 WFP/UNICEF/WHO, UNFPA, UNESCAP 등과 전개했던 보건 사회 경제 통계부문의 기술지원(Technical Assistance) 및 역량강화(Capacity Building) 협력 사례를 검토한 뒤, 이에 대한 시사점을 논의하였다. 이러한 국제협력을 통해 북한중앙통계국 관료 들은 통계조사기법 산출 평가 등에 대한 전반적인 통계역량을 강화할 수 있었고, 국제표준, SDGs SNA 시스템 등의 새로운 통계지식과 기술을 습득할 수 있었다. 아울러 남북협력 차원에서도, 국제기구를 통한 남북통계협력을 추진해 볼 수 있다는 점에서도 동 주제는 중요한 시사점을 갖는다.

한국 체류 난민의 사회적응에 영향을 미치는 요인

손주희 경인행정학회 2018 경인행정학회 학술대회 Vol.2018 No.02

미용사의 직무스트레스 대처방법에 관한 연구

손주희,강연수 한국인체미용예술학회 2002 한국인체미용예술학회지 Vol.3 No.2

  The purpose of this study is to provide essential information for the beauticians to cope with their stress<BR>  The results of the research are as follows :<BR>  1. The average point in the frequency at which beauticians used the method to cope with the working stress was 3.16.<BR>  In the method wise, 3.34 was for the method of problem analysis and 2.99 was for that of emotional approach. The method used most frequently was "try to get more information about the work" (3.69), on the contrary, "ask professionals for help or consult them" (1.98) was used least.<BR>  2. In the study of the correlation between beauticians general characteristics and the method they used to cope with their working stress, the correlation between anthropological and social characteristics and the method of problem analysis found the difference in "age" (p<0.05), "school career as a beautician" (p<0.001), "working position" (p<0.01), "the number of employees" (p<0.001), and "satisfaction degree to the work" (p<0.001), however, the difference only in "motivation they chose the job with" (p<0.05).<BR>  According to the survey, to cope with working stress, currently, the method of problem analysis is used more frequently, the method of emotional approach, however, has also shown considerable contribution. As a result, the support from both society and employers is definately needed for the beauticians to apply an efficient coping method suitable for the situation after finding out the stress in the early stage.

헤어스타일과 선호감각유형의 관련성

손주희,이용환,정규식 국제보건미용학회 2011 국제보건미용학회지 Vol.5 No.1