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손영택,도의선 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2
Four-different crystal forms of prednisolone, two polymorphic forms and two pseudopolymorphic forms, were obtained by the recrystallization from different organic solvents under varying conditions. The isolated crystal forms were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and X-ray powder diffraction (XRD). Form 1 was the most stable form that had the highest melting point and melt at 250.2℃. Form 2 wast a monohydrate and Form 2 was a methanol solvate. The endothermic peak of Form 4 was shown at 230.2℃. When stored at different relative humidity over the period of 3 months, all of the modifications did not undergo transformation. The dissolution patterns of these four modification were also checked in distilled water at 37±0.5℃, for 120 minutes. The dissolution rate of Form 4 was highest and those of Form 3, Form 2, Form 1 followed. Form 2, Form3 and Form 4 had higher dissolution rate than Form 1.
손영택,김소영 德成女子大學校 藥學硏究所 1996 藥學論文誌 Vol.7 No.1
Four crystal forms of cephalexin were prepared and characterized by DSC and TGA. Their dissolution patterns were checked and it was confirmed that the theory of Higuchi was not always correct. All crystal forms were stable.
손영택,이경이 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1
Three polymorphic modifications and one amorphous form were prepared by recrystallization under various conditions and characterized by DSC and X-ray crystallography. At 37±0.5℃. the polymorphic modifications showed significant differences in the dissolution rate. The dissolution rate of Mod. 4, amorphous form was faster than of other polymorphic modifications. When all modifications were stored at 52% RH, 95% RH, and in silica get desiccator, amorphous form was transformed at 95% humidity condition.
손영택,전임작 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1
Three new polymorphic modifications were prepared by recrystallization under various conditions and characterized by DSC and X-ray crystallography. In pH 4.0 buffer at 37±0.5℃, the polymorphic modifications showed significant differences in the dissolution rate. The dissolution rate of Mod. 4, amorphous form, was faster than that of marketed cefaclor (Mod.1). When all modifications were stored at 52% RH, 95% RH and in silica gel desiccator, any polymorphic transformation was not observed.
손영택 德成女子大學校 藥學硏究所 1994 藥學論文誌 Vol.5-6 No.1
DSC was utilized as a tool for the rapid evaluation of interactions of Cortex Mori extract with excipients in preformualtion compatibility and stability studies.
손영택,김희경 德成女子大學校 藥學硏究所 1998 藥學論文誌 Vol.9 No.1
Three polymorphic modifications and two pseudopolymorphic modifications of cefotaxime sodium were obtained by crystallization from different organic solvents. The isolated crystal forms were characterized by UV spectrophotometry. DSC, TGA and X-ray crystallography. Crystal forms of cefotaxime sodium were also compared by dissolution rate. The dissolution rate of form 1 was the highest, followed by form 2, form 4, form 6, form5 and form 3. Among these polymorphic modifications the dissolution rate of form 3 and form 5 was much slower than that of cefotaxime sodium on the market. All forms showed no change after 2-month storage test in the silica gel desiccator. But after the storage of 2-month at 95% relative humidity condition, all forms were deliquesced by hygroscopic property except form 1 that showed the highest dissolution rate. At 52% relative humidity condition, form 1, form2 and form 6 had no evidence of phase transformation, but form 3, form 4 and form 5 were also deliquesced.
결정형(Habit)이 아스피린과 페나세틴의 용출 속도에 미치는 영향
손영택,조지운 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.2
Some studies reported physicochemical factors of drugs affecting solubility and dissolution rate. However, few have been reported about pharmaceutical application of crystal forms (habits). Therefore, using acetylsalicylic acid and phenacetin as model substances, we monitored the effects of crystal forms on the dissolution rates.
손영택 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.1
A new form of sulfabenzamide was characterized using X-ray diffraction patterns and differential scanning calorimetry. Solubility studies demonstrated that, of the sulfabenzamide polymorphs, the new form was more soluble than form I. Compression of the new form at compression force of 1000 ㎏/㎠ didn't induce polymorphic change in the crystal. Similar patterns were also produced through grinding. The effects of some diluents on the polymorphic transformation from the new form into form I by grinding and compression were also studied. Three diluents, Avicel^ⓡ, lactose and starch showed no influence on the polymorphic transformation. The new form seemed to be more suitable for the pharmaceutical preparation.
손영택 덕성여자대학교 약학연구소 2009 藥學論文誌 Vol.20 No.-
Dosage form development using crystal form of Esomenprazole was pursued.