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Substance P가 파골세포 증식 및 골흡수 능력에 미치는 효과
손수준 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.10
Background and Objectives:Osteoclasts are the principal cell of bone resorption playing a major role in focal bone erosion asociated with cholesteatoma. This study was conducted in order to investigate direct effect of substance P (SP) on osteoclasto-genesis and osteoclastic bone resorption in vitro. Materials and Method:SP dose response was measured in receptor activator for NF-κB ligand (RANKL)-induced mouse osteoclast culture and osteoclastic bone resorption asay. RT-PCR was performed for the expresion of neurokin(NK) receptor mRNAs in osteoclasts. Results:Treatment with SP (100 nM and 1000 nM) signifi-cantly increased osteoclastogenesis. SP (0.1 nM and 1 nM) significantly increased resorption surface area on dentin slices by osteoclasts. Cultured osteoclasts expresed NK-2 receptor mRNA. Conclusion:(Korean J Otolaryngol 2003 ;46 :822-6)
내이질환에 동반된 이명에서 고실내 Dexamethasone투여의 효과
손수준,신동원,김우석 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.9
Background and Objectives:Intratympanic steroid serves as a good therapeutic alternative for various inner ear diseases pre-senting with vertigo, hearing los, and tinnitus. This study reports the effect of intratympanically injected dexamethasone (IT-DEXA) Subjects and Method:19 patients with cochlear tinnitus (7 sudden sen-sorineural hearing los (SNHL ), 5 noise induced hearing los, 4 Menieres disease and 3 acoustic trauma) were subjected to the IT-DEXA. The injection was performed with a spinal nedle through the posterior superior quadrant of the tympanic membrane for 2 to 5 consecutive days. Results:The overall improvement rate was 31.6%. Tinnitus was improved in 4 patients with SSNHL Conclusion:IT-DEXA is a therapeutic modality for tinnitus in SSNHL and Menieres disease.