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Recent Advances of Biodegradable Polymers for Medical Applications
성정석,성용결 한국생체재료학회 2006 생체재료학회지 Vol.10 No.3
The recent advances of biodegradable polymers for medical applications have been reviewed on the basis of biodegradability, functionality, and biocompatibility. These include the functional biodegradable polymers synthesized in our research laboratory and some injectable biodegradable polymers developed for biomedical applications. The biodegradable polymers synthesized from Krebs cycle acid derivatives, injectable biodegradable block copolymers, biodegradable polymers for RNA interference and DNA matrix-based biopolymeric systems for tissue engineering have been also discussed briefly.
유미경,조정수,성용결 한국생체재료학회 2003 생체재료학회지 Vol.7 No.3
The temperature- and pH-sensitive hydrogels were synthesized by copolymerizing varying ratios of N-isopropyl acrylamide(NIPAAm) and acrylic acid (AAc). The influence of polyelectrolyte on the lower critical solution temperature (LCST) of temperature/pH sensitive hydrogels was investigated in the pH range of 2~12. The LCSTs of the poly(NIPAAm-co-AAc) hydrogels were strongly affected by pH and AAc content. At same pH, the LCSTs of the poly(NIPAAm-co-AAc) hydrogels in the presence of PAA were lower than those of the poly(NIPAAm-co-AAc) hydrogels due to the polyelectrolyte complex formation between PAAc and PAA. Swelling ratio of poly(NIPAAm-co-AAc) hydrogels as a function of pH at various temperature was obtained by measuring the weight of the hydrogels in buffer solutions. Swelling ratio of the hydrogels in the presence of poly(allyl amine)(PAA) as a polyelectrolyte was also measured at the same conditions. The swelling kinetics of poly(NIPAAm-co-AAc) hydrogel was strongly dependent on pH value, temperature, and polyelectrolyte solute. Pulsatile swelling experiments were conducted by transferring gel disks from one combination of pH and temperature to another that the critical pH and temperature would be crossed between swelling and shrinking regimes. Indomethacin was loaded into these hydrogels and drug release from the hydrogels was studied under various temperatures and pHs.