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오기욱 ( Ki-wook Oh ),설진곤 ( Jin-gon Sul ) 국군의무사령부 2012 대한군진의학학술지 Vol.43 No.1
가속도 내성 훈련 시 발생하는 Gravity induced loss of consciousness (G-LOC)은 다양한 요인에 의하여 영향 받을 수 있다. 이번 연구의 목적은 가속도 훈련 중 발생하는 G-LOC에 미치는 육체적 생리적 요인을 분석하여 G-LOC 발생의 예측 요인을 발견하는 것이다. 연구 결과로 G-LOC의 발생과 관련된 인자로 항G복의 착용유무, anti-gravity straining maneuver, 커피 섭취 유무, 자율신경계 특히 부교감신경의 활성도와 연관이 있었다. 따라서 G-LOC을 예방하기 위하여 자율신경계 활성과의 연관성에 관한 연구가 필요할 것이다. Objectives : Previous studies indicate that 8-13% of pilots have experienced G-induced loss of consciousness (G-LOC). Due to altered state of awareness and relative incapacitation time, G-LOC is one of the most serious threats to aircrews flying in high-performance fighter aircrafts. Demographic factors, lifestyles, physiological factors and flying factors may be determinant risk factors for G-LOC. In this study, we investigated the factors associated with G tolerance. Methods : Data were collected by interviewing 122 fighter aircraft pilots and requesting information on visual symptoms and G-LOC-associated symptoms. They underwent high-G training at the Aerospace Medical Center, ROKAF. Details regarding demographic factors, lifestyles, physiologic factors and flying factors were performed. Heart rate variability was examined in 42 pilots at sitting rest before high-G training. Results : Of the 122 pilots, 11.4% had experienced at G-LOC in the high G environment. Multiple regression analyses yielded that G-LOC was inversely correlated with anti-G suit, anti-G straining maneuver (AGSM) and intake of coffee. There was a significant increase in Lf/Hf associated with G-LOC as compared with G exposures without symptoms. Conclusion : These findings indicate that fighter pilots are experiencing a similar rate of G-LOC when compared with previous studies. AGSM, G-suit, coffee intake and autonomic activity are determinants of G tolerance.
최승민,중수영,설창안,설진곤,권민수 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.7
It has been reported that hypobaric hypoxia exposure by high altitude is responsible for neuropsychological impairment. In the present study, we examined an effect of hypobaric hypoxia on the writhing test. The ICR mice were exposed in hypobaric chamber with several altitudes (5000, 10,000 or 20,000 ft) for 1 or 2 h, and then immediately injected intraperitoneally (i.p.) with 1% acetic acid for writhing test. Our results show that both 10,000 ft and 20,000 ft exposure induce antinociceptive effect in writhing test, but 5,000 ft does not. In addition, this antinociceptive effect was abolished by L-NAME (nitric oxide synthase inhibitor) pre-treated intraperitoneally, but not naloxone (non-specific opioid receptor antagonist). Furthermore, we examined that neuronal NOS immunoreactivities in the hypothalamus (paraventricular nucleus and arcuate nucleus) were increased by hypobaric hypoxic exposure (10,000ft). These results suggest that hypobaric hypoxic-induced antinociception may be associated with neuronal NOS IR in the hypothalamus.
권민수 ( Min-soo Kwon ),정수영 ( Soo-young Chung ),설창안 ( Chang-ahn Seol ),설진곤 ( Jin-gon Sul ) 국군의무사령부 2011 대한군진의학학술지 Vol.42 No.1
In the present study, we examined the change of pain behaviors induced by formalin injected subcutaneously (s.c.) into the hind paw, or substance P (SP) and glutamate injected intrathecally (i.t.) in the mouse immobilization stress model. The mouse was restrained either once for 1 h or five times for 5 days (once/day). In the formalin test, a single immobilization stress attenuated pain behaviors (licking, biting or scratching) in the second phase, while it had no effect on the pain behaviors revealed during the first phase. In addition, repeated immobilization stress attenuated pain behaviors revealed during the second phase but not in the first phase. A single as well as repeated immobilization stress decreased pain behaviors induced by substance P i.t. injection, but there were no significant changes in the glutamate test. These results suggest that a single and repeated immobilization stress differentially affects such nociceptive processing induced by formalin, SP, glutamate and pro-inflammatory cytokines in different manners.
가속도 부하 환경과 저압 저산소 환경의 쥐의 간에 대한 효과
설창안 ( Seol Chang Ahn ),정수영 ( Chung Soo Young ),설진곤 ( Seol Jin Gon ) 국군의무사령부 2010 대한군진의학학술지 Vol.41 No.1
Objectives: Extreme environments, such as hypergravity and hypobaric hypoxia may alter the homeostasis of the liver. We tried to find out if there are some kinds of injuries in the rat liver after the exposure to the chronic intermittent hypobaric hypoxia and/or hypergravity. Methods : We used male Sprague-Dawley rats, which were divided into 4 groups of C, G, H and G+H. Group C was the control group, and group G was exposed only to the hypergravity of 10 G for 10 minutes daily. Group H was exposed only to the hypobaric hypoxia of altitude of 25,000 feet for 1 hour daily. Group G+H was first exposed to the hypergravity and was next exposed to the hypobaric hypoxia daily. The exposure to the extreme conditions was continued for 15 days. After the exposure we checked liver function tests and did the pathologic analysis of the liver. Results: Serum AST and ALT levels in group H and G+H were lower than in group C. Serum total protein (TP) and albumin levels in group G and G+H were higher than in group C. In the pathologic analysis of liver, we found centrilobular necrosis in group G, H and G+H and hyperplastic change of bile ducts in group H and G+H. Conclusions: Chronic intermittent hypobaric hypoxia decreased serum AST and ALT levels and chronic intermittent hypergravity increased serum TP and albumin levels in the rat. The sequence of the pathologic significance may be group C << G < H < G+H.