http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 석지우(Ji-Woo Seok) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
알코올 사용 장애자의 현출 네트워크의 기능적 연결성 증가
석지우(Ji-Woo Seok),박미숙(Mi-Sook Park) 대한인간공학회 2019 大韓人間工學會誌 Vol.38 No.6
Objective: The aim of this study is to identify the altered functional connectivities of the salience network during resting state among individual with alcohol use disorder using functional magnetic resonance imaging. Background: Individuals with Alcohol Use Disorder (AUD) has shown significant attention and attraction to alcohol-related stimuli. The previous studies demonstrated the neuropsychological, physiological responses elicited by alcohol-related cue. These researches suggested the altered functional connectivities between brain areas related to incentive salience among AUD patients, but not yet fully explored the functional connectivities in salience network during resting-state among AUD patients in the literatures. Method: In this study, functional magnetic resonance imaging data were acquired for 22 AUD patients and 22 healthy controls with similar demographic characteristics. The functional connectivities between the regions in salience network was chosen as the region of interest (ROI), and the ROI to ROI analysis with time series signals was conducted. After that two-sample t test was performed. Results: In the results, AUD patients exhibited increased functional connectivities in the right anterior insula - left supramarginal gyrus, the right supramarginal gyrus - left rostral prefrontal cortex, right supramarginal gyrus - right rostral prefrontal cortex, and right supramarginal gyrus - left supramarginal gyrus compared to healthy controls. The strengths of functional connectivity in these areas were linked to the severity of AUD measured by Alcohol Use Disorder Identification Test (AUDIT). Conclusion: The results of the study suggest that abnormal incentive salience toward alcohol-related stimuli might be associated with the aberrant functional connectivities in salience network. Application: The aberrant functional connectivities in salience network might apply for discrimination of AUD, and determination the severity of AUD as neuroimaging markers.
-
석지우(Ji-Woo Seok),손진훈(Jin-Hun Sohn) 대한인간공학회 2019 大韓人間工學會誌 Vol.38 No.5
Objective: The purpose of this study is to find brain areas shown a difference of the volume and cortical thickness between females with major depressive disorder (MDD) and healthy females. Background: Although neuroimaging studies on the characteristics of MDD have been accumulating, limited studies have used both brain volume and cortical thickness to find the structural alteration in MDD. Integrating measures of structural brain imaging provide profound insights into the neurobiological underpinnings of MDD. Method: Twenty-two females with MDD and 23 age- and sex-matched healthy females participated in this study. A 3T Philips Achieva MRI scanner (Philips Medical Systems, Best, The Netherlands) was used for image acquisition. Gray matter volume and cortical thickness were analyzed using voxel-based morphometry (VBM) and surface-based morphometry (SBM). Results: VBM results indicated that individuals with MDD had significantly reduced gray matter volume in the anterior cingulate gyrus, hippocampus, hippocampal gyrus and precuneus and cerebellum compared to controls. Moreover, gray matter volume in the right anterior cingulate gyrus was negatively correlated with the severity of depression. SBM results demonstrated that compared to healthy controls, individuals with MDD showed reduced cortical thickness in temporal pole, paracentral gyrus, angular gyrus and insula. Conclusion: These findings suggest that structural alterations in the anterior cingulate gyrus are linked to MDD, thereby providing understanding into the neural mechanisms underlying MDD. Application: Alterations in the anterior cingulate cortex may act as neuroimaging markers of MDD, and these findings provide a possibility to developed the diagnosis system for MDD.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
