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변속 원활감 향상을 위한 DETENT PIN GROVE 형상 최적화
서홍석(Hongsuk Suh) 한국자동차공학회 2009 한국자동차공학회 부문종합 학술대회 Vol.2009 No.4
In Europe, the proportion of manual transmission cars is over 80%. That is why development of manual transmission considering Europe is important from now on. So in this paper the preferred gearshift feeling in Europe was studied and the principal control factors were selected considering engineering. From the selected control factor, Detent Pin Groove profile was chosen as the key control factor for its analysis was unsatisfied and it has a great influence in improving gearshift feeling. Detent Pin Groove profile was optimized to gain accurate and simple operation of shifting gears. Therefore, improvement of groove profile applying optimization can gain effective results in developing gearshift feeling considering specific region.
Park, Yoo-Hoi,Kim, Jung-Ae,Baek, Jin-Hyen,Jung, Eun-Jin,Kim, Tae-Hyong,Suh, Hongsuk,Park, Mying-Hwan,Kim, Kyu-Won 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-
The effects of ursodeoxycholic acid (UDCA) and its novel derivative, named as HS-1030, on the proliferation of HepG2, human hepatocellular carcinoma cells were investigated. Whereas UDCA had no significant effect in a concentration range we have tested, HS-1030 inhibited the proliferation of HepG2 cells in a concentration dependent manner. Surprisingly, HS-1030 had no effect on the proliferation of Human Chang liver cell which is a normal liver cell line. We also found that proliferation-inhibitory effect of HS-1030 was due to the induction of apoptosis of HepG2 cells, which was confirmed by observing the internucleosomal DNA fragmentation and morphological changes (i.e, cell shrinkage, nuclear condensation and the formation of apoptotic bodies). These results suggest that HS-1030 may be a good candidate as a drug for the treatment of liver cancer.