Mesna 사용 후 협부 발진양 알레르기 반응을 보인 2예

서정철 ( Jeong Cheol Seo ),배상철 ( Sang Cheol Bae ),심승철 ( Seung Cheol Shim ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),유대현 ( Dae Hyun Yoo ),김성윤 ( Seong Yoon Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.2

Hemorrhagic cystitis is potentially life-threatening sequellae of chemotherapy using oxazaphosphorine alkylating agents (cyclophosphamide and ifosfamide). Mesna contains a sulfhydryl group that is believed to bind acrolein within the urinary collecting system and reduce the hemorrhagic cystitis without affecting the chemotherapeutic potential. To date, about thirty cases of hypersensitivity or allergic reactions of the delayed and urticarial type associated with mesna have been reported. We reported two patients with systemic lupus erythematosus who developed facial rash and flushing associated with mesna which imitate malar rash.

일제치하(日帝治下)부터 1970년대까지의 한국(韓國) 침구학사(鍼灸學史)에 대한 고찰

서정철,남상수,안병철,Seo, Jung-Chul,Nam, Sang-Soo,Ahn, Byung-Cheol 대한침구의학회 2001 대한침구의학회지 Vol.18 No.4

Objective ; This Study was carried out to review the history of acupuncture & moxibustion in Korea under the control of imperialized Japan and to compare the history among Korea, China and Japan. Results ; Under the control of imperialized Japan the science of acupuncture & moxibustion in Korea has experienced the dark ages because of the momentary disordered medical laws made by Japan. As we compare the history of acupuncture & moxibustion among Korea, China and Japan, Korea was simple but systemic, China was complicate but complex and Japan was nearly surgical. Conclusion ; The science of acupuncture & moxibustion of Korea was mostly advanced in the late Chosun and did not just imitate that of China and has advanced uniquely.

Bee Venom 및 Melittin 약침액(藥鍼液)이 신경아세포종(神經芽細胞腫)의 세포사(細胞死)에 미치는 영향(影響)

강동철,정태영,서정철,임성철,한상원,Kang, Dong-cheol,Jung, Tae-young,Seo, Jung-chul,Leem, Seong-cheol,Han, Sang-won 대한침구의학회 2003 대한침구의학회지 Vol.20 No.2

Objective : This study was designed to analyze the effects of bee venom and melittin on cell death in neuroblastoma cell line. Methods : MTT assay, morphologic method, DNA fragmentation, flow cytometry, immunocytochemistry analysis, RT-PCR and Western blot were performed. Results : The obtained results are summarized as follows: 1. The MTT assay demonstrated that neuroblastoma cell viability was significantly inhibitted dose-dependently by treatment with bee venom and melittin in comparison with control. 2. Cell culture demonstrated that control group proliferated highestly at he 5th day in comparison with the 4th day in bee venom and melittin group. And in bee venom and melitti group cell proliferation decreased 2.5 times than control group. 3. The morphologic study demonstrated that neuroblastoma cell showed apoptosis after treatment with bee venom and melittin for 6 hours using microscope. 4. The Flow cytometry demonstrated that apoptosis of neuroblastoma cell treated with bee venom and melittin was related with stop of cell cycle in stage of $G_0/G_1$. 5 .DNA fragmenation demonstrated that neuroblastoma cell treated with bee venom and melittin showed DNA ladder below 1 Kbp. 6. Immunocytochemistry assay demonstrated that Fos and MAPK which are related with cancer were down-regulated by treatment with bee venom and melittin. 7. RT-PCR analysis demonstrated that Fos and MAPK mRNA were transcripted. Fos was down-regulated form treatment with $5{\mu}g/ml$ bee venom and MAPK was down-regulated form $1{\mu}g/ml$ bee venom. 8. Western blot demonstrated that Fos was down-regulated from $1{\mu}g/ml$ bee venom whereas MAPK was expressed by $1{\mu}g/ml$ bee venom but down-regulated by $10{\mu}g/ml$ bee venom. Conclusions : We found that some cancer related genes ware down-regulated by treatment with bee venom and melittin. Further study is needed for investigating the anti-cancer effect of bee venom and melittin.

방재역량 강화를 위한 방재교육훈련 활성화방안 연구

서정표,조원철,Seo. Jung Pyo,Cho. Won Cheol 한국방재학회 2012 한국방재학회논문집 Vol.12 No.2

비구조적 재해대책의 주요 수단 중 하나인 방재교육훈련은 `재난 및 안전관리 기본법` 제 34조를 근거로 중앙민방위방재교육원이 주축이 되어 중앙 및 지방자치단체와 유관기관 등에서 방재관련 교육훈련을 실시하고 있다. 그러나 법적 제도적 장치의 부재로 말미암아 교육기회의 부족과 전문성이 없고 업무지식 및 경험부족 등으로 인해 미숙한 재해대처가 발생되고 있다. 또한 시설 환경적 측면에서 교육훈련시설, 안전체험 공간, 기자재 등 인프라가 열악하다. 한편, 교육 운영측면에서도 토론식 탁상훈련(TTX), 역할연기, 현장체험 등 참여형 교육보다는 전통적인 강의기법과 공급자 위주의 교육운영 등으로 인해 교육훈련의 성과가 저조한 실정이다. 따라서 본 논문은 방재역량 강화를 위한 일환인 방재교육훈련의 활성화 방안을 아래와 같이 제시하였다. 첫째, 법적 제도적인 측면에서 방재교육훈련을 총괄 조정 가능토록 가칭 `방재교육훈련 활성화 및 전문인력 양성에 관한 법률` 제정의 필요성을 역설하였으며, 둘째, 시설 환경적인 측면에서는 교육훈련을 담당한 조직의 한계를 극복할 수 있도록 가칭 `국립방재교육인력원`으로의 기구의 확대와 교육인프라 보강방안을 제시하였다. 마지막으로 교육운영 측면에서는 수요자 중심의 교육커리큘럼, 참여형 교육 기회의 확대와 함께 지속인 교육훈련 환류장치의 마련 등을 제시하였다. Education on disaster prevention, one of the Non-structural Disaster Countermeasures, is being carried out by many institutions such as the `Central Civil Defense and Disaster Prevention Institute`, other central or local government and related-institutions, in compliance with Article 34 of the Disaster and Safety Management Basic Act. Disaster prevention education, however, has been facing a lot of problems, as people still do not have enough educational opportunities to expand their skills in the field of disaster prevention. For example, lack of infrastructure such as educational facilities, experimental spaces and equipment has been an issue as well as the participatory learning methods such as tabletop exercise, role play, and field experience have not yet settled down. In other hand, traditional teaching methods such as supplier-oriented education are still the ones prevailing, therefore, it is not easy to obtain good results in disaster prevention education. In this sense, this study investigated the current problems in disaster prevention education, and sought ways to revitalize specific programs as means of enhancing the disaster prevention capabilities as followings. Firstly, this study emphasizes the importance of enactment of `Act for Revitalizing Education and Training Experts in Disaster Prevention`. Secondly, it presents a way of enhancing educational infrastructure through the organizational extension of the existing National Disaster Management Institution. Lastly, it suggests the extension of consumer oriented educational curriculums and participatory learning methods along with constant feed-back system in disaster prevention education.

자연재해 구호물자관리 자동화시스템 구축 및 효과분석

서정표,조원철,Seo,Jung Pyo,Cho,Won Cheol 한국방재학회 2014 한국방재학회논문집 Vol.14 No.4

우리나라는 매년 태풍, 홍수 등으로 인한 자연재해가 빈번하게 발생하고 있으며, 특히 최근에는 기후변화 등의 영향으로 인하여 그 피해규모가 점차 증가하고 있는 실정이다. 현행 구호행정의 한 분야인 구호물자의 관리와 배분은 현장에서 정보를 취득하고 사무실에서 다시 국가재난관리시스템(NDMS; National Disaster Management System)에 입력하는 체계로 현장에서의 업무와 사무실에서 업무가 중복되는 점이 있다. 그리고 현장자료를 정리하는데 시간이 많이 소요되고 있으며 수작업으로 구호물자를 관리하기 때문에 실시간 정보공유가 되지 않아서 구호물자의 지급지연 및 이중지급 등의 문제점을 지니고 있다. 본 연구에서는 이러한 문제점을 해결하기 위하여 U-IT를 기반으로 구호물자를 효율적으로 관리하는 정보화 시스템 구축에 대하여 고찰하였다. 스마트폰과 RFID(Radio Frequency Identification)를 활용한 재해 구호물자 관리가 가능한 모바일 기반의 재해구호 물자관리 자동화 시스템을 개발하고 구축효과를 살펴보았는데, 연간 950백만 원의 예산절감 등 기대효과가 있을 것으로 분석되었다. In Korea, natural disasters such as typhoons and floods occur frequently each year. Recently, however, due to climate change and other factors, the scale of damages from such natural disasters started to steadily increase. Our country existing relief goods management and distribution system, information is collected on the spot and then inputted into the National Disaster Management System (NDMS). Thus, the onsite work is duplicated in the office. Moreover, it takes much time to put the field information in order and the relief goods are managed manually, so the information cannot be shared in real time, which results in problems such as delays and duplicate payment of relief goods. To solve these problems, this research proposes the establishment of an information system for efficient management of relief goods based on U-IT. A mobile-based automated relief goods management system in which relief goods can be managed using a smartphone and Radio Frequency Identification (RFID) technology was developed, and the effectiveness of the system was analyzed. The analysis showed that the developed system is expected to effectively reduce Korea`s budget for relief administration by 950 million won a year.

Preventive Effects of Hominis Placenta Extract on H₂O₂-Induced Apoptosis in Pineal Gland Cell Line

서정철,이재동,박동석,강성길,안병철,김이화,김순애,이희제,김창주,정주호,Seo, Jung-Chul,Lee, Jae-Dong,Park, Dong Suk,Kang, Sung-Keel,Ahn, Byung-Cheol,Kim, Ee-Hwa,Kim, Soon Ae,Lee, Hee Jae,Kim, Chang-Ju,Chung, Joo-Ho 대한침구의학회 2001 대한침구의학회지 Vol.18 No.3

목적 : 본 연구는 최근 임상에서 많이 사용하는 자하차(紫河車) 약침액(藥鍼液)이 과산화수소($H_2O_2$)로 야기된 송과선 세포의 apoptosis에 있어서 세포 보호에 미치는 영향과 그 기전을 분석하였다. 방법 및 결과 : MTT assay를 이용하여 분석한 결과 처리 시간 및 농도에 따른 세포 독성의 효과가 $H_2O_2$ 투여로부터 관찰되었다. 또한 자하거 약침액은 세포 증식 효과를 나타내었고 자하거 약침액을 전처치하고 $H_2O_2$를 처치하였을 때 세포 독성이 크게 감소되었다. DAPI staining에서 자하거 약침액 투여군은 $H_2O_2$ 투여군에 비해 fragmentation이 억제되었다. TUNEL assay를 통하여 자하거 약침액 투여군은 $H_2O_2$ 투여군에 비하여 TUNEL 양성세포의 발현이 감소되었다. Flow cytometry를 통하여 자하거 약침액 투여군은 $H_2O_2$ 투여군에 비하여 세포주기 중 sub G1 분획의 증가가 억제되었다. 결론 : 이상의 결과를 통하여 자하거 약침액이 $H_2O_2$로 유발된 apoptosis에서 세포보호 효과가 있음이 확인되었다.

Protective Mechanism of Hominis Placenta Extract Against H₂O₂-Induced Apoptosis in PGT-β Cells

Jung-Chul Seo(서정철),Jae-Dong Lee(이재동),Dong-Suk Park(박동석),Sung-Keel Kang(강성길),Byung-Cheol Ahn(안병철),Ee-Hwa Kim(김이화),Soon-Ae Kim(김순애),Hee-Jae Lee(이희제),Chang-Ju Kim(김창주),Joo-Ho Chung(정주호) 대한한의학회 2001 대한한의학회지 Vol.22 No.3

황련해독탕 약침, 자하거 약침의 침감에 대한 임상적 연구 - placebo 약침을 위한 기초연구 (2) -

윤종석,서정철,이향숙,임성철,정태영,신임희,한상원,Yoon, Jong-seok,Seo, Jung-chul,Lee, Hyang-sook,Lim, Seong-cheol,Jung, Tae-young,Shin, Leem-hee,Han, Sang-won 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4

Objective : This study was designed to find out whether NS(normal saline) is able to be constituted as an appropriate control group for HHT(Hwangryunhaedoktang herbal acupuncture) and HP(Homnis Placenta herbal acupuncture). Methods : NS and two herbal acupuncture were inserted into Quchi(LI 11) of the subjects. After 5 minutes the subjects completed a questionnaire rating the intensity of 21 kinds of acupuncture sensation; hurting, penetrating, sharp, aching, intense, spreading, radiating, tingling, pricking, stinging, pulling, heavy, dull, numb, electric, shocking, hot, burning, cool, pulsing, and throbbing. We compared the subjective acupuncture sensation between the two groups. Results : As for HHT seven items of the acupuncture sensation were significantly different from NS. In case of HP just two items were significantly different from NS. Conclusion : We found that NS may be able to be an placebo herbal acupuncture for HP. Further study is needed for the appropriate placebo herbal acupuncture.

이중맹검을 위한 Sham Acupuncture에 대한 임상연구

임정아,서정철,이은용,이향숙,문형철,최선미,황우준,조남근,김성철,Lim, Jeong-A,Seo, Jung-Chul,Lee, Eun-Yong,Lee, Hyang-Sook,Moon, Hyung-Cheol,Choi, Sun-Mi,Hwang, Woo-Joon,Cho, Nam-Geun,Kim, Sung-Chul 대한침구의학회 2006 대한침구의학회지 Vol.23 No.5

Background and Purpose : Though there were many clinical studies of acupuncture effects they didn't have appropriate control group. So we didn't say it was true acupuncture effect, though subjects in clinical study improved. To investigate the possibility of sham acupuncture application, we examined how well subjects distinguished real acupuncture from sham acupuncture. Methods : We investigate the possibility of sham acupuncture application as the following 3 kinds of methods. 1. The public (n=60) and Oriental Medicine Doctors (n=20) looked at the appearance of acupuncture and then were treated with randomly allocated acupuncture and judged it as real or sham. 2. The public (n=60) and Oriental Medicine doctors (n=20) were treated with randomly allocated acupuncture, then they looked at the appearance of acupuncture and judged it as real or sham. 3. The public (n=60) were treated with randomly allocated acupuncture (right-real-left-sham), (right-sham-left-real), (left-real-right-sham), (left-sham-right-real), then they judged it as real or sham. Results : 1. When the public (n=60) looked at the acupuncture appearance, the correct judgement ratio was 63.3%. After they were treated with acupuncture, the correct judgement ratio was 50.0%. 2. When Oriental Medicine doctors (n=20) looked at the acupuncture appearance, the correct judgement ratio was 25.0%. After they were treated with acupuncture, the correct judgement ratio was 45.0%. 3. When the public (n=60) were treated with acupuncture, the correct judgement ratio was 50.0%. After they looked at the acupuncture appearance, the correct judgement ratio was 63.3%. 4. When Oriental Medicine doctors (n=20) were treated with acupuncture, the correct judgement ratio was 65.5%. After they looked at the acupuncture appearance, the correct judgement ratio was 65.0%. 5. After the public (n=60) were treated with randomly allocated sham or real acupuncture as (right-real-left-sham), (right-sham-left-real), (left-real-right-sham), or (left-sham-right-real). the correct judgement ratio was 66.7% in looking at the acupuncture appearance group, and in not looking at 60.0%. Conclusion : These results indicated that Kim Sham Acupuncture could apply to the double blind clinical study of acupuncture effect. And more continuous studies are needed on Sham Acupuncture apparatus.

사전재해영향성검토협의제도의 효율성 제고를 위한 연구

박인찬,조원철,서정표,홍철,Park,In-Chan,Cho,Won-Cheol,Seo,Jung-Pyo,Hong,Cheol 한국방재학회 2008 한국방재학회 학술발표대회논문집 Vol.2008 No.1

As the procedure of the close examination of disaster impact at the initial stage of the beginning of development plans, the newly extablished Pre Disaster Impact Assessment Review Deliberation (PDIARD) system which have been introduced through the revision of the Natural Disaster Countermeasure Act-revised at August, 2005 is enforced for the purpose of the disaster prevention which caused during a development projects. From that time down to this day, the PDIARD system have been reviewed about 6,000 cases totally. However, the current the PDIARD system at the uppermost limit in the aspect of every Acts and operational problems is in need of sustaining supplementation at the present situation. To cope with this operational remedy related to the PDIARD system, this study deals in 3 major concerns. First, it is required to fix a criterion in detail because of a wide range of the subject plans of deliberation. Second, there is some ambiguity according to the area or length of the subjected administrative and development plans. So it should be excepted of the targeted plans which has few probability in disaster potential or vulnerability. Finally, the subjected plans need to be added as to the continuous urbanization and industrialization and the enactment or revision of the Acts related. This study focuses on the investigation and analysis to find out the improvement way about the main problem pending of the PDIARD system, consequently suggests a effective remedy and new categories, including future directions and detailed plans for operation.