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권혜정,김소연,조창이,최영륜,신종희,서순팔,Kwon, Hye Jung,Kim, So Youn,Cho, Chang Yee,Choi, Young Youn,Shin, Jong Hee,Suh, Soon Pal 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.6
목 적: 신생아 집중 치료술의 발달로 고위험 신생아의 생존율이 많이 개선되었지만 적극적인 침습적 시술의 증가로 신생아 사망과 이환의 주요한 원인이 되는 신생아 감염의 발생은 오히려 높아졌다. 본 연구는 신생아 중환자실에서 원내 감염의 분포 양상, 원인균, 발생 빈도 및 변화 양상 등 5년간의 추이를 알아보기 위해 실시하였다. 방 법: 1995년 1월부터 1999년 12월까지 전남대학교병원 신생아 중환자실에 입원하여 혈액, 피부, 기관내 튜우브, 카테테르, 눈, 소변, 대변, 뇌 척수액에서 시행한 균 배양 검사 상 양성으로 나온 환아들 중 선천성 감염을 제외하고 임상 증상으로 원내 감염이 의심되었던 환아들에서 원내 감염의 분포 양상과 원인균 및 혈중 감염의 빈도, 원인균, 사망률 추이에 대하여 조사하였다. 결 과 : 5년 동안 신생아 중환자실에 입원한 환아의 원내 감염률은 입원 환아 100명당 9.0례이었고, 감염소로는 혈중 감염이 32.3%로 가장 많았으며, 피부(18.4%), 기관내 튜우브(17.2%), 카테테르(10.6%), 눈(10.0%), 소변(6.1%), 대변(3.0%), 뇌 척수액(2.4%) 순이었다. 원인균은 S. aureus가 29.9%로 가장 많았고 coagulase-negative staphylococci(CONS), Enterobacter,Candida 순이었다. 감염소별 원인균은 혈중과 카테테르는 S. aureus와 CONS, 피부와 눈은 S. aureus, 기관내 튜우브는 Enterobacter, 소변은 Candida와 enterococci, 그리고 대변은 Pseudomonas와 S. aureus가 흔하였고, 다병소 감염율은 26.1%이었다. 원내 감염률은 입원 환아 100명당 1995년 9.5례에서 1999년 11.6례로 증가하였으며, 원인균으로 S. aureus 는 감소하고 CONS, Candida, Klebsiella, Acinetobacter baumannii는 증가하는 추이를 보였다. 동기간 동안 혈중 감염률은 입원 환아 100명당 3.6례였으며, CONS와 S. aureus가 가장 많았다. 혈중 감염률은 입원 환아 100명당 1995년 2.1례에서 1999년 5.2례로 증가하였는데 원인균으로 S. aureus는 감소하고 CONS, Candida, Klebsiella, Acinetobacter baumannii는 증가하는 추이를 보였고, 패혈증에 의한 사망률은 11.9%이었다. 결 론 : 신생아 원내 감염의 가장 흔한 감염소는 혈중 감염이고 원인균으로는 S. aureus가 가장 흔하며, CONS, Candida, Klebsiella, Acinetobacter baumannii에 의한 감염은 증가하는 추이이므로, 이에 대한 예방 및 치료를 위한 노력이 필요할 것으로 사료된다. Purpose : Neonates in neonatal intensive care units(NICU) have a high risk of acquiring nosocomial infection because of their impaired host defence mechanism and invasive procedures. Nosocomial infection result in considerable morbidity and mortality among neonates. This study was carried out to survey both the epidemiology of nosocomial infection in our NICU and the annual trends of pathogens. Methods : We retrospectively reviewed culture proven nosocomial infection which occurred in our NICU from January 1995 to December 1999. The data included clinical characteristics, site of infection, pathogens, and mortality. Results : Nosocomial infection rates was 9.0 per 100 NICU admissions during the five-year period. Major sites of infection were bloodstream(32.3%), skin(18.4%), endotracheal tube(17.2%), and catheter(10.6%). The most common pathogen was S. aureus(29.9%). and the others were coagulase- negative staphylococci(CONS)(14.8%), Enterobacter(12.4%), and Candida(9.0%). During the five-year period, nosocomial infection rates increased from 9.5 to 11.6 per 100 admissions with the increase of CONS, Candida, Klebsiella, and Acinetobacter baumannii. The infection rate of S. aureus decreased. Multiple episodes of nosocomial infection occurred in 26.1% of all nosocomial infections. Overall bloodstream infection rates were 3.6 per 100 NICU admissions during five years. CONS(29.1%) and S. aureus(27.1%) were the two most common pathogens. Increasing rates of bloodstream infection by CONS, Candida, Klebsiella, and Acinetobacter baumannii were observed. Bloodstream infection related mortality was 11.9%. Conclusion : The predominant pathogens of nosocomial infection in NICU were S. aureus and CONS. Bloodstream infection, the most frequent nosocomial infection, should be a major focus of surveillance and prevention efforts in NICU.
만성간염 환자의 혈청에서 중합효소연쇄반응을 이용한 HBV DNA 및 HCV RNA 검출소견
박용욱(Yong Uk Park),서강석(Kang Suk Suh),한상우(Sang Woo Han),김신묵(Sin Mook Kim),최성규(Sung Kyu Choi),서순팔(Soon Pal Suh),김세종(Sei Jong Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.5
Objectives: It is well-known that chronic hepatitis can be caused by hepatitis viral infection, drugs and toxins, inborn errors of metabolism, and autoimmume disease. Hepatitis B (with or without superimposed hepatitis D) and hepatitis C viral infections are known as the common causes of chronic viral hepatitis. Recently there have been several reports that chronic hepatitis and chronic liver disease can be caused by the superinfection or co-infection of HBV and HCV. We detected HBV DNA and HCV RNA in patients with chronic hepatitis using polymerase chain reaction and compared polymerase chain reaction with enzyme immunoassay in evaluating the presence of a superinfection or co-infection of HBV and HCV. Methods : Using sera from 61patients with histologically proven chronic hepatitis (chronic active hepatitis' 51cases, chronic persistent hepatitis: 10cases), we checked the HBV DNA and HCV RNA using polymerase chain reaction. We also checked the HBV and HCV markers using enzyme immunoassay. Results: 1) Only HBV DNA could be detected in 37patients (60.7%). HBV DNA and HCV RNA were detected in 11patients (18%). Only HCV RNA was dectected in 4patients (6.6%). Neither HBV DNA nor HCV RNA was found in 9patients (14.8%). 2) HBV DNA and HCV RNA were detected in 11patients (18%) whereas HBsAg or anti-HBe and anti-HCV were seropositive in 4patients (6.5%). 3) The positive rates of HBsAg and HBV DNA were 83.6% and 78.7%, respectively, and the positive rates of HBV DNA in HBsAg-positive cases and in HBeAg-positive cases were 90.2% and 93.0%, respectively. 4) The positive rates of anti-HCV and HCV RNA were 11.5% and 24.6%, respectively, and the positive rates of HCV RNA in anti-HCV positive cases and in anti-HCV negative eases were 85.7% and 14.8%, respectively. Conclusion: It has been suggested that hepatitis B viral infection is the most common cause of chronic hepatitis in Korea, and that hepatitis C virus might also play an etiological role. In this study, we found that 18% of chronic hepatitis patients were superinfected or co-infected with HHV and HCV, and that polymerase chain reaction was more sensitive than enzyme immunoassay to detect HBV and HCV infection when superinfection or Qo-infection was suspected.
에어탈 정 ( 아세클로페낙 100mg ) 에 대한 세니탈 정의 생물학적 동등성
김수진(Soo Jin Kim),오인준(In Joon Oh),박행순(Haeng Soon Park),서세민(Se Min Seo),서순팔(Soon Pal Suh),이용복(Yong Sok Lee) 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.4
Bioequivalence of two aceclofenac tablets, the Airtal^(TM) (Daewoong Pharmaceutical Co., Ltd.) and the Senital^(TM) (Hana Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20∼29 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100 ㎎ of aceclofenac was orally administered, blood was taken at predetermined time intervals and the concentration of aceclofenac in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_t) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_t between two tablets were 3.69%, 2.44% and 0.51%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_t were 87.85%, 98.70% and more than 99%, respectively. Detectable differences (Δ) and confidence intervals were all less than ±20%. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Senital^(TM) tablet is bioequivalent to Airtal^(TM) tablet.