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박홍용,박영길,서만성,Hong-Ryong Park,M,D,Young-Kil Park,MD,Man-Seong Seo,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.4
Purpose: To determine the clinical effect of radial optic neurotomy (RON) in central retinal vein occlusion (CRVO). Methods: The retinal findings, visual acuity and complications were analyzed in patients who had undergone RON for the treatment of CRVO and were followed up 10 months or more after surgery. Results: Of all 16 patients (16 eyes), the mean age was 55 years and the follow-up period was 14 months. Preoperative anterior segment and retinal neovascularization was observed in each three eyes. All eyes showed improvement in the retinal findings within two weeks after RON. The postoperative complications included vitreous hemorrhage in 1 eye, chorioretinal collateral circulation in 1 eye, neovascular glaucoma in 1 eye, vitreous hemorrhage and neovascular glaucoma in 1 eye. The visual acuity was counting fingers or less in 8 eyes preoperatively and in 2 eyes finally, and was less than 0.1 in 13 eyes preoperatively and in 10 eyes finally. The mean visual improvement in the 3.8 lines was in 11 eyes and a loss of 2.5 lines in 2 eyes. The maximum velocity of the blood flow of CRV improved with 1.95±0.93 cm/sec on the average in the 7 eyes examined by color doppler. Conclusions: RON appears to be safe and effective for improving the retinal findings, visual acuity and blood flow of CRV in CRVO. However, the visual recovery is limited.
각막신생혈관에 대한 버테포르핀을 이용한 광역학치료의 동물실험
나현주,윤경철,임욱빈,안규윤,서만성,Hyeon-Ju Nah,M,N,Kyung-Chul Yoon,Wook-Bin Im,Kyu-Youn Ahn,Man-Seong Seo 대한안과학회 2005 대한안과학회지 Vol.46 No.4
Purpose: To determine the efficacy of photodynamic therapy (PDT) with verteporfin (Visudyne?, Norvatis Ophthalmics AG, Hettingen, Switzerland), a benzoporphyrin derivative, in the treatment of corneal neo- vascularization (CN) in a rabbit eye model. Methods: CN was induced by placing instrastromal sutures in the cornea. Two weeks after suturing, verteporfin was administrated intravenously and 1 hour later, the right eye (treated group) was exposed to a laser with a 689 nm wavelength, and the left eye was used as the control. The changes in CN were analyzed using biomicroscopy and optical microscopy in twelve rabbits. Results: The mean percentages of the neovascular area in the control and treated groups were 96.4±1.9% and 90.3±3.5% (P=0.009) at three days after the PDT, 88.6±4.6% and 71.6±6.2% (P<0.001) at one week, and 76.8±4.4%와 43.6±15.1% (P<0.001) at two weeks, respectively. Optical microscopy showed significant differences between the control and treated group in terms of the area and number of CN (P<0.05). Conclusions: PDT with verteporfin is a safe and effective procedure for regressing CN. However, a further study will be necessary.