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Alternaria brassicicola SW-3의 항진균 활성
정동선,라여정,변한나,정은영 서울여자대학교 자연과학연구소 2003 자연과학연구논문집 Vol.15 No.-
The fungus Alternaria brassicicola is a causal agent of black leaf spot in. several cruciferous plants. We found A. brassicicola SW-3 produced antifungal metabolite, in addition to depudecin, reported as a histone deacetylase inhibitor. The metabolite produced by A. brassicicola SW-3 exhibited antifungal activity against various filamentous fungi such as Rhizopus, Mucor, Aspergillus, Microsporium, and Trichophyton. The antifungal metabolite was extracted with ethyl acetate from the culture filtrate of A. brassicicola, and purified through silica gel column chromatography. The purified compound exhibited a broad antifungal spectrum, particularly potent activity against Microsporum canis and Trichophyton rubrum which are dermatophytes associated with cutaneous Mycosiscause. The purified metabolite showed very complex spectral data from proton and carbon-13 NMR analysis, indicating the compound contains both lipid and carbohydrate moiety. Although structure of the antifungal metabolite is not elucidated yet, these preliminary results suggest that the antifungal metabolite from A. brassicicola could be used as a lead compound for treatment of skin diseases caused by filamentous fungi.