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무하마드하룬 ( Muhammad Haroon ),변성원 ( Seong Won Byeon ),강선철 ( Sun Chul Kang ) 한국환경농학회 2022 한국환경농학회 학술대회집 Vol.2022 No.-
The zebrafish (Danio rerio) is now commonly employed to explore host-pathogen interactions especially as a model for human illnesses, such as bacterial-induced lung infections. The toxicity of E. coli OP50, S. aureus and E. coli- ESBL was investigated in the zebrafish model. The embryos were exposed to a bacterial solution with various cell numbers (1×10<sup>4</sup>, 1×10<sup>5</sup>, 1×10<sup>6</sup>, 1×10<sup>7</sup> and 1×10<sup>8</sup> CFU/ml) at 6, 24, 72 and 96 hpf. The survival rate, hatching rate and heartbeat were determined at the end of the experiment, however, the structural anomalies of the larvae were determined during the experiment with an interval of 12 hours. The E. coli OP50 is a non-pathogenic strain, and as a result no serious abnormalities were observed in the larvae except for the higher concentration, 1×10<sup>7</sup> on which affected the hatching rate and cardiac activity slightly. In the S. aureus and E. coli- ESBL infected groups there were no deformities recorded in 1×104 CFU/ml bacterial treatment; however, in 1×10<sup>5</sup>, 1×10<sup>6</sup>, and 1×10<sup>7</sup> CFU/ml morphological abnormalities, delayed development and lower cardiac activity was observed in larvae post 48 hpf. However, in 1×10<sup>8</sup> CFU/ml treatment of these groups all the embryos were found dead at 48 hpf. The zebrafish model offers significant benefits over mammalian models of infection in terms of scientific, budgetary, and ethical considerations.