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폐경 쥐 모델에서 두류 섭취에 따른 자궁의 비타민 D 수용체의 발현
김태희 ( Tae Hee Kim ),박준식 ( Jun Sik Park ),이해혁 ( Hae Hyeog Lee ),이우석 ( Woo Seok Lee ),정수호 ( Soo Ho Chung ),박용순 ( Yong Soon Park ),변동원 ( Dong Won Byun ) 대한폐경학회 2013 대한폐경학회지 Vol.19 No.1
Objectives: Phytoestrogen-containing pulse supplements have beneficial effects on postmenopausal symptoms, but how such effects are achieved is unclear. This study investigates the effects of pulse consumption on the menopausal changes in ovariectomized rats. Methods: Female Sprague-Dawley rats were either sham operated (Sham; n = 3) or surgically ovariectomized (n = 13). The Sham group was fed the regular AIN-93M diet. Ovariectomized group was divided into 3 sub-groups and fed AIN-93M containing soybean (n = 5), mung bean (n = 3), or cowpea (n = 5) for 10 weeks. At the end of the experiment, all rats were sacrificed, and the uterus was harvested, rinsed, and weighed. Expressions of vitamin D receptor (VDR), estrogen receptor (ER) β, and ezrin in uterus were evaluated by immunohistochemistry. Results: VDR was highly expressed in the uterus of rat, irrespective of ovariectomized state. VDR was more definitely expressed in the uterus of ovariectomized groups than the sham-operated group. There were no significant differences in expression of ER β. However the expression of ezrin was highly expressed in the cowpea group compared to sham group (P = 0.044). Conclusion: This study suggested that legumes diet may concern menopausal changes via VDR and ezrin. The result may partly explain the beneficial effects of VDR on menopausal symptoms. Further study is necessary to study the detailed mechanisms of VDR and ezrin on the menopausal changes in the uterus. (J Korean Soc Menopause 2013;19:1-8)
김우강(Woo-Kang Kim),고준빈(Jun-Bin Ko),변동해(Dong Hae Byun) 한국기계가공학회 2010 한국기계가공학회지 Vol.9 No.4
The constant velocity internal grinding is a popular process for studying axle machine design and process in automobile industry. In this study, The program which gives the data of wheel size and truing diameter of ball groove is developed. As a result I obtained the data of grinding conditions makes good surface roughness get a grinding conditions. The grinding characteristics and conditions of constant velocity joint were investigated with respect to grinding feed, cutting depth, grinding time. At machine failure, the results were suddenly increased and the detailed surfaces were extremely obtained. Grinding condition was big more affected by grinding depth, grinding speed and grinding time.
티록신 억제 요법에 반응하지않는 양성 갑상선 결절의 수술소견
이혜경,김극배,유명희,서교일,변동원 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.4
Background: Fine needle aspiration and biopsy(FNAB) has known the most accurate test(about 90%) in the preoperative evaluation of patients with a thyroid nodule. The false negative findings of thyroid cancer by FNAB are mainly due to the aspiration of cystic fluid in cystic degeneration of thyroid cancer and the ipossibility of differentiation between follicular adenoma and carcinoma by aspiration or FNAB because of the failure to evaluate the capsule invasion or angioinvasion of the tumor. Actually more than 80% of the nodules are found as benign nodules in aspiration or FNAB and the findings of follieular lesions are found about half of the samples tested, so limiting the cancer incidence in surgically resected samples up to 50% of the surgical resection. Sa reasonable guidelines to manage the benign nodules on aspiration or FNAB are needed which can select the maligna~nt nodules with false negative findings on aspiration or FNAB. We tried to evaluate whether the thyroxine suppression therapy can increase the malignancy rates on thyroidectomy, Methods: We treated the benign thyroid nodules in FNAB with thyroxine for 1 year and cornpared the nodule volume change before and after treatment (every 6 month) with ultrasonogram. We performed thyroidectomy on 1~7 thyroid nodules wbich showed less than 50% decrease of nodule volume after 1 year of thyroxine suppression therapy. Results: The results were as follows: 1) Of all 17 patients, surgical resection revealed malignant thyroid nodule(Group I) in 10 cases (58.82%, papillary cancer. 6 cases, follicular cancer: 4 cases) and benign thyroid nodule(Group II) in 7 cases(41.18%, follicular adenoma: 4 cases, adenomatous goiter: 3 cases). 2) Between group I and II, there was no significant differences in serum T, T and TSH levels before and after thyroxine suppression therapy. Also, there were no significant difference in TSH suppression % between group I and group II(5.60+5.39%, 14.64+11.48%, respectively). 3) Thyroid nodule volume decrease percent before and after thyroxi~ne therapy showed no significant difference between group I and group II (124.80+54.18% vs 159.42+79.82%, p$gt;0.05). Conclusion: Our data suggested that the benign thyroid nodules on aspiration or FNAB which were not suppressed in volume after thyroixine therapy revealed more than 50% incidence of malignancy on surgical resection, so these nodules were highly reeommended to surgical exploration. (J Kor Soc Endocrinol 11:401~408, 1996)
포상기태(Hydatidiform mole)에 의해 발생된 심한 갑상선중독증 1예
이재학,박종근,권순효,목지오,윤지성,김여주,박형규,김철희,김상진,이해혁,남계현,권계현,고은석,변동원,서교일,유명희 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.4
저자들은 무월경의 11주의 27세 환자에서 심한 갑상선중독증을 동반하고, β-HCG가 1,123,0001U/L으로 크게 증가되었으나, 흡입소파술 시행후 임상 증상과 갑상선기능 그리고 β-HCG가 모두 정상으로 호전된 포상기태 (Hydatidiform mole) 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Human chorionic gonadotropin(HCG) is one of the glycoproteins families synthesized by the placenta, and consists of 2 noncovalently joined subunits, namely, α' and . The α' and -subunits have a structural homology with the α' and -subunits of TSH and LH. The thyrotropic action of HCG results from its structural similarity to TSH, so -HCG can bind to the TSH receptor in the thyroid gland. A high level of HCG, accompanied by an increased thyroid hormone level, can be observed in gestational trophoblastic diseases (GTD), such as a hydatidiform mole or a chorio- carcinoma. However, the clinical symptoms of hyperthyroidism in GTD are rarely observed. A 27-years-old woman, admitted due to an amenorrhea of 11 weeks duration, with thyrotoxic symptoms, such as weight loss, palpitation, sweating, tremor, heat intolerance and anxiety, was evaluated. Her serum free T4 level was 8 times higher than normal, and her serum -HCG level was over l,OO0,00OIU/L. She had a curettage operation, with the pathological findings of a complete hydatidiform mole. These thyrotoxic symptoms developed due to a hydatidiform mole, and were accompanied with a highly increased serum β-HCG level. After evacuation of the molar tissue, the thyroid hormone and thyrotoxic symptoms normalized. Here, this case is reported, with brief review of the literature (J Kor SOC Endocrinol 18:420425, 2003).