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Monoterpenoid 계의 새로운 항암제 합성 및 In vitro 세포독성 평가
이민정(Min Jung Lee),백형근(Hyung Gun Baek),김대근(Dae Keun Kim),이강노(Kang Ro Lee),정규혁(Kyu Hyuk Chung),지옥표(Ok Pyo Zee),정영훈(Young Hoon Jung) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.3
N/A Many attention has been focused on developing new chemotherapeutic agents for a treatment of cancer from natural products. From Carpesium divaricatum S. et Z. (Compositae), various monoterpenoid compounds were isolated and exhibited mild antitumor activity against human tumor cell lines. `These facts prompted us to explore the structure-activity relationship of these compounds. The synthesis of monoterpenoid compound was accomplished by Fries rearrangement, Grignard reaction, elimination, allylic oxidation, esterification and epoxidation as key steps. The results of in vitro cytotoxicity (A549, SK-OV-3, SK-MEL-2, XF498, HCT15) of the synthesised compounds are as follows: First of all, epoxide moiety is prerequisite for cytotoxic activity in diester compound. Any kind of compounds with olefin or diol moiety instead of epoxide ring exhibited poor or mild cytotoxic activity respectively. Of o-acetoxy and isobutoxy epoxy esters, p-substituted phenylacetate compounds exhibited high cytotoxic activities against SK-MEL-2 and HCT15.
아시아티코사이드로부터 메칠 2β, 3β-에폭시-23-히드록시우르스-12-엔-28-오애이트의 합성 및 이의 환원적 에폭시환 개열반응
주상섭,임두연,서성기,남태규,박형근,김희두,김창민,이민희,백형근,이민정,정영훈 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Steroidal 2β, 3β-epoxy compound was prepared from asiaticoside via six steps and reduced regioselectively with lithium aluminum hydride. Epoxide ring opening furnished 9 as a sole product at reflux condition through axial hydride attack at C-3.
아시아티코사이드로부터 메칠 2beta, 3beta-에폭시-23-히드록시우르스-12-엔-28-오애이트의 합성 및 이의 환원적 에폭시환 개열반응
주상섭(Sang Sup Jew)임두연(Doo Yeon Lim),서성기(Sung Ki Seo),남태규(Tae Gyu Nam),박형근(Hyeung Geun Park),김희두(Hee Doo Kim),김창민(Chang Min Kim),이민희(Min Hee Lee),백형근(Hyeung Geun Paik),이민정(Min Jung Lee),정영훈(Young Hoon J 대한약학회 1998 약학회지 Vol.42 No.5
Steroidal 2beta, 3beta-epoxy compound was prepared from asiaticoside via six steps and reduced regioselectively with lithium aluminum hydride. Epoxide ring opening furnished 9 as a sole product at reflux condition through axial hydride attack at C-3.