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RISS 인기검색어
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- 저자 : 백종욱 ( Jong Uk Baek ) (검색결과 3 건)
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2세 이하 아토피피부염 환아에서 비타민 D 부족과 식품항원 감작의 연관성
백종욱 ( Jong Uk Baek ),황보준원 ( Jun Won Hwangbo ),이혜란 ( Hae Ran Lee ),이소연 ( So Yeon Lee ) 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3
Purpose: Vitamin D levels are known to be associated with development of allergic diseases. However, existing data are controversial. The aim of this study was to investigate whether vitamin D levels are associated with food sensitization (FS) in young children with atopic dermatitis (AD). Methods: We performed a medical record review of all patients under 2 years presenting to pediatric allergic clinic in Hallym University Sacred Heart Hospital for atopic dermatitis between March 1, 2012 and February 28, 2013. Serum 25-hydroxyvitamin D (25(OH)D) levels and six specific immunoglobulin E (IgE) to common food allergens were measured in 132 young children with AD. We defined vitamin D insufficiency was 25(OH)D <30 ng/mL, and FS as specific IgE ≥0.35 IU/mL to any of six common food allergens. Associations between serum 25(OH)D levels and FS were examined by using multiple logistic regression, adjusting for potential risk and confounding factors. Results: The mean age was 10.1 months. Among the 132 children with AD, 65.9% had FS. In this group, there was a negative correlation between 25(OH)D levels and serum eosinophil percentage (correlation coefficient [r]=.0.335, P<0.01), but not correlated with serum total IgE levels. Children with vitamin D insufficiency were more likely to have FS (adjusted odds ratio, 17.1; 95% confidence interval, 1.36 to 215; P=0.028) than those with adequate vitamin D levels. Conclusion: Vitamin D insufficiency is associated with FS in young children with AD. Further research is needed to confirm these findings. (Allergy Asthma Respir Dis 2013;1:211-215)
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일과성 Immunoglobulin G 결핍증이 있는 아토피피부염 환아에서 면역글로불린 치료
백종욱 ( Jong Uk Baek ),이혜란 ( Hae Ran Lee ),이소연 ( So Yeon Lee ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.3
Background: Some studies have reported that intravenous immunoglobulin is an effective treatment of severe atopic dermatitis. Case History: A 3-month-old by present suffered from atopic dermatitis with skin infection since the age of 50 days. He was fed on breast milk and had no familial history of allergy. Upon admission, his body weight was 6.9 kg (50 percentile), and the Severity Scoring of Atopic Dermatitis was 80. Laboratory test results were as follows: white blood cell 23.1×103/uL, eosinophil (%) 29%, immunoglobulin E 696.2 IU/mL, immunoglobulin G 126 mg/dL (176∼601 mg/dL), immunoglobulin A 14.7 mg/dL (1.3∼53 mg/dL), immunoglobulin M 31.7 mg/dL (17∼105 mg/dL). Staphylococcus aureus was detected in the erosive cheek by skin cultures. Specific immunoglobulin E levels to egg white, soy, and peanut were elevated. He was initially treated with intravenous antibiotics, wet dressing, steroid ointments, and mother`s dietary restriction. However, the skin infection and atopic dermatitis remained uncontrolled, and the immunoglobulin G level was still below the normal range. The patient was given intravenous immunoglobulin 1 g/kg/day for 2 consecutive days. Results: After 4 days, the skin infection was controlled. After 9 months, immunoglobulin G level was normalized. Conclusion: We reported a patient who was diagnosed with severe atopic dermatitis with transient immunoglobulin G deficiency and whose symptoms improved after intravenous administration of immunoglobulin.
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2세 이하 아토피피부염 환아에서 비타민 D 부족과 식품항원 감작의 연관성
백종욱 ( Jong Uk Baek ),황보준원 ( Jun Won Hwangbo ),이혜란 ( Hae Ran Lee ),이소연 ( So Yeon Lee ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3
Purpose: Vitamin D levels are known to be associated with development of allergic diseases. However, existing data are controversial. The aim of this study was to investigate whether vitamin D levels are associated with food sensitization (FS) in young children with atopic dermatitis (AD). Methods: We performed a medical record review of all patients under 2 years presenting to pediatric allergic clinic in Hallym University Sacred Heart Hospital for atopic dermatitis between March 1, 2012 and February 28, 2013. Serum 25-hydroxyvitamin D (25(OH)D)levels and six specific immunoglobulin E (IgE) to common food allergens were measured in 132 young children with AD. We defined vitamin D insufficiency was 25(OH)D <30 ng/mL, and FS as specific IgE ≥0.35 IU/mL to any of six common food allergens. Associations between serum 25(OH)D levels and FS were examined by using multiple logistic regression, adjusting for potential risk and confounding factors. Results: The mean age was 10.1 months. Among the 132 children with AD, 65.9% had FS. In this group, there was a negative correlation between 25(OH)D levels and serum eosinophil percentage (correlation coefficient [r]=-0.335, P<0.01), but not correlated with serum total IgE levels. Children with vitamin D insufficiency were more likely to have FS (adjusted odds ratio, 17.1; 95% confidence interval, 1.36 to 215; P=0.028) than those with adequate vitamin D levels. Conclusion: Vitamin D insufficiency is associated with FS in young children with AD. Further research is needed to confirm these findings. (Allergy Asthma Respir Dis 2013;1:211-215)
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