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영지버섯 균사체 (Ganoderma lucidum IY009)로부터 추출한 단백다당체의 항암활성
백성진(Seong Jin Baek),김용석(Yong Seok Kim),용환미(Hwan Mee Yong),채주병(Ju Byung Chae),윤환민(Hwan Min Yun),박동우(Dong Woo Park),김동연(Dong Yeon Kim),이정옥(Jeong Ok Lee),이준우(June Woo Lee),박승국(Seung Kook Park) 대한약학회 2001 약학회지 Vol.45 No.6
In this study, the antitumor activities were investigated using β-Immunan, a proteoglycan obtained from cultured mycelia of the IYO09 strain of Ganoderma lucidum IY009belonging to basidiomycetes. The result showed the significant effect of cytotoxicity test against murine sarcoma 180 and murine Iymphocytic leukemia L1210 using immunized macrophage cultures by β-Immunan. When intraperitoneally injected at 40 mg/kg/day daily for 10 days, β-Immunan inhibited the growth of sarcoma 180 solid tumor in ICR mice by 88.8% (p<0.05). It was also observed that β-Immunan increased life span by 85.2% (p<0.01) after treatment of 100 mg/kg/day in BDFI mice bearing Iymphocytic leukemia L1210. And combination therapy with cisplatin (dosage: 4 mg/kg) increased life span by 140.4% (p<0.05) after treatment of 100 kg/mg/day in BDFI mice bearing Iymphocytic leukemia L1210.
백성진(Baek, Seong-Jin),김태오(Kim, Tae-O),한상환(Han, Sang-Whan) 대한건축학회 2017 大韓建築學會論文集 : 構造系 Vol.33 No.5
Steel ordinary moment frame(steel OMF) has been used as a seismic force resisting system in regions of low and moderate seismicity. In this study, the seismic performance of the steel OMFs with various heights in SDC Cmax was evaluated. For this purpose, nine steel OMFs were designed according to seismic design codes(ASCE/SEI 7-10, ANSI/AISC 341-10), and the collapse probability of these steel OMFs were estimated using FEMA P-695. The collapse probability of steel OMFs became larger with an increase in the height of frames. Some of steel OMFs designed according to current design codes did not satisfy the acceptance criteria specified in FEMA P-695.
영지버섯 균사체 ( Ganoderma lucidum IYO09)로부터 추출한 단백다당체의 전이암 억제 효과
백성진(Seong Jin Baek),김용석(Yong Seok Kim),용환미(Hwan Mee Yong),채주병(Ju Byung Chae),이선애(Sun Ae Lee),배우철(Woo Chul Bae),박동우(Dong Woo Park),김동연(Dong Yeon Kim),이준우(June Woo Lee),박승국(Seung Kook Park) 대한약학회 2002 약학회지 Vol.46 No.1
β-Immunan, a proteoglycan, was isolated from the mycelium of Ganoderma lucidum which belongs to a medicinal mushroom. The effects of β-Immunan on cell- cell and cell-matrix interactions mediated by carbohydrate-recognition and the mechanism responsible for the inhibition of experimental metastasis of Bl6-FIO and B16/BL6 murine melanoma were studied. The results showed that Ganoderma lucidum-Immunan inhibited Bl6-Fl melanoma cell's adhesion to laminin and asialofetuin-induced homotypic aggregation and reduced invasion against Bl6-FIO murine melanoma cells through matrigel in vitro assay: When β-Immunan was intraperitoneally administrated to C57BL/6 mice bearing B16/BL6 murine melanoma cells, it was decreased the number of pulmonary metastatic colony by the dose dependent manner ranging from 20 to 100 mg/kg/day, The results indirectly indicate that clinical treatment with β-Immunan might be expected to exhibit anti-metastatic effect. In the put-monary metastasis, the number of pulmonary metastatic colony of melanoma when β-Immunan was intraperitoneally aduunistrated to C57BL/6 mice bearing Bla/BL6 murine melanoma cells by intravenous injection were decreased by the dose dependent manner ranging from 20 to 100 mg/kg/day.
마우스에서 2,4-Dinitrochlorobenzene을 이용한 아토피성 피부염 발현 관련 면역지표치 분석
이승혜(Seung Hye Lee),백성진(Seong Jin Baek),김형아(Hyoung Ah Kim),허용(Yong Heo) 한국독성학회 2006 Toxicological Research Vol.22 No.4
This study was undertaken to develop a reliable mice model demonstrating similar immunologic phenomena as human atopic dermatitis characterized with predominance of type-2 immune response. BALB/c mice and NC/Nga mice were sensitized twice with 100 ㎕ of 1% 2,4-dinitrochlorobenzene (DNCB) or vehicle (acetone : olive oil = 4 : 1 mixture) in a week and challenged twice with 100 ㎕ of 0.2% DNCB or the vehicle at the following week. Mice were sacrificed at 19 days following the second DNCB or vehicle challenge for NC/Nga mice and at 28 days following the second DNCB or vehicle challenge for BALB/c mice. Upregulation of plasma IgE, a hallmark of atopic dermatitis occurrence, was evident in the plasma obtained 4 day after the second DNCB challenge from BALB/c mice (approximately 4-fold) and NC/Nga mice (approximately 6-fold) treated with DNCB in comparison with that of the vehicle treated-control mice, and remain higher 3~4 week after the second challenge. Ratio of plasma IgG1 versus IgG2a concentration was significantly higher in the mice treated with DNCB than the control mice, which also implies the skewed type-2 reactivity in vivo. Ratio of interleukin-4 versus interferon gamma produced in the splenic T cell culture supernatants was approximately 3-fold higher in the both strains of mice treated with DNCB than their control mice, respectively. The DNCB-treated mice demonstrated atopic dermatitis-like skin legions characterized with erythma, scaling, and hemorrhage, which was not observed with the control mice. Scratching on face or dorsal area was significantly more frequent (approximately 25-fold) in the DNCB-treated mice than the control at next day of the second DNCB challenge, and scratching frequency remains higher (approximately 4-fold) in the mice treated with DNCB than the control at 14 day following the second DNCB challenge. Overall, the mice model developed through sensitization and challenge with DNCB may be useful for research on atopic dermatitis and development of treatment materials for atopic dermatitis.