스포츠 건강의학 : 운동하면 머리도 좋아진다

백성수 한국스포츠과학원 2010 스포츠과학 Vol.110 No.-

수분 및 탄수화물-전해질 음료보충이 고온환경에서 장시간 운동시 스트레스 호르몬에 미치는 영향

백성수 空軍士官學校 1998 論文集 Vol.41 No.-

The purpose of this study was to analyze the effects of fluid ingestion on stress hormones during prolonged exercise in high temperatures, mainly at 32℃ with relative humidity 61±3%. Under these fixed conditions, eight heathy university male students performed on the bicycle ergometer at 60% V0_2max for 120 minutes. For comparison and evaluation, the study was divided into three cases 1, without any fluid intake 2, with water intake 3, with carbohydrate-electrolyte fluid intake(all performed at the same exercise intensity and time conditions noted above). 1.Case one 0 without fluid Venous blood samples were drawn at intervals a. prior to the exercise b. during the exercise c. directly after the exercise session. 2-3. Case two & three - with fluid intake mesured fluid was ingested every 15 min and venous blood samples were drawn at the intervals noted above. The results of the study is summarized as follows: A. Without Fluid 1)Highest increase rate in ACTH and Cortisol 2)High increase in Epinephrine and Norepinephrine B.With Water intake 1)Middling increase rate in ACTH and Cortisol 2)High increase in Epinephrine and Norepinephrine C.With Carbohydrate-electrolyte fluid intake 1)Lowest increase rate in ACTH and Cortisol 2)High increase in Epinephrine and Norepinephrine The results from the study indicate in each case, an increase in ACTH, Cortisol, Epinephrine, and Norepinephrine at assessed times. However, the rise in the stress hormone level was distinctively lower when fluid(water or carbohydrate-electrolyte)was consumed. There was no relationships between fluid ingestion and assessed times. The obtained analysis leads to the conclusion that fluid ingestion during prolonged exercise in the heat is required for physiological, biochemical normalization and homeostasis of human body.

Treadmill exercise inhibits traumatic brain injury-induced hippocampal apoptosis

백성수 PERGAMON-ELSEVIER SCIENCE LTD 2010 PHYSIOLOGY & BEHAVIOR - Vol.101 No.5

심장에서 세포내 Mg²⁺ 농도 의존적 Mg²⁺ 유리

백성수,김상진,김진상,Baek, Sung-soo,Kim, Shang-jin,Kim, Jln-shang 대한수의학회 2000 대한수의학회지 Vol.40 No.2

Magnesium ($Mg^{2+}$) transport across the plasma membrane of cardiac myocytes appears to be under hormonal control. Repeated stimulations with adrenergic or histaminergic agonist produced a progressive decrease in $Mg^{2+}$ efflux from hearts. Thus we hypothesized that the $Mg^{2+}$ efflux may be resulted from a down-regulation of receptors or from a depletion of $Mg^{2+}$ from intracellular pool(s) in the hearts. In the present study, the regulation of $Mg^{2+}$ homeostasis by receptor stimulation was studied in perfused rat and guinea pig hearts. The successive short addition of norepinephrine (NE) to rat and guinea pig, and of histamine (HT) to perfused guinea pig hearts induced a progressive decrease in $Mg^{2+}$ efflux. These $Mg^{2+}$ effluxes were blocked by propranolol or ranitidine, respectively. These decrease in $Mg^{2+}$ efflux were inhibited by sodium cyanide (NaCN), which increases intracellular $Mg^{2+}$ ($[Mg^{2+}]_i$) levels. When NE (or HT) was added after HT (or NE), this efflux was also decreased in the guinea pig hearts. In the rat hearts and myocytes, HT did not stimulate $Mg^{2+}$ efflux. But NE produced a large $Mg^{2+}$ efflux after stimulation with HT. 8-(4-Chlorophenylthio)-adenosine cAMP (cAMP), like NE and HT, also induced a progressive decrease in $Mg^{2+}$ efflux in guinea pig hearts. This effect was inhibited by NaCN. These data provide evidence that the progressive decrease in receptor-stimulated $Mg^{2+}$ efflux is considered to be due to a decrease in $[Mg^{2+}]_i$ levels rather than receptor down-regulation.

뇌 해마의 신경세포생성과 운동의 항우울 효과

백성수 한국운동재활학회 2007 JER Vol.3 No.2

흰쥐 관류 간장에서 L-dopa 및 Dopamine이 Mg^(2+) 유리에 미치는 영향

백성수,강형섭,김진상 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.3

Magnesium is one of essential minerals for all cells. In mammals it is the second most abundant intracellular cation. Magnesium shows many roles in various physiological processes. Although recent studies demonstrated that adrenergic receptor stimulation evokes marked changes in Mg^(2+) homeostasis, the regulation of Mg^(2+) by dopamine and dopamine precursors is not yet known. The purpose of this study was to identify the mobilization of Mg^(2+) by dopamine and dopamine precursors in the perfused rat livers. Mg^(2+) content was measured by atomic absorbance spectrophotometry. Mg^(2+) efflux was increased by L-dihydroxyphenylalanine (L-dopa) or dopamine but not by L-tyrosine from rat liver. L-dopa-induced Mg^(2+) efflux was inhibited or partial inhibited by β-methyldopa and diethyldithiocarbamate (DEDC), inhibitors of catecholamines converting enzyme. But dopamine-induced Mg^(2+) efflux was not inhibited by DEDC or phenylpropargylamine, inhibitors of dopamine β-hydroxylase. Fluphenazine, dopaminergic antagonist, inhibited dopamine-induced Mg^(2+) efflux. L-dopa-induced Mg^(2+) efflux was also inhibited or partial inhibited by fluphenazine. In addition, the Mg^(2+) efflux by L-dopa or dopamine was completely inhibited by adrenergic antagonists (propranolol and prazosine) or imipramine. These results indicate that the Mg^(2+) efflux from rat liver could be induced by L-dopa and dopamine, and these effects can be mediated by the dopaminergic and/or adrenergic receptor stimulation.

런던올림픽 성과와 과제 ; 스포츠과학, 너는 세상과 통하였구나!

백성수 한국스포츠과학원 2012 스포츠과학 Vol.121 No.-

The Challenges of Exercise Science

백성수 한국운동생리학회 2025 운동과학 Vol.34 No.1

Effects of Low-Intensity Endurance Exercise Rehabilitation Program on Substrate Metabolism and Insulin Sensitivity in Obese Women

백성수 한국운동재활학회 2010 JER Vol.6 No.1

비만과 2형 당뇨는 인슐린 저항성과 지질을 산화시키는 능력이 손상된 것 같은 특징을 지닌 것과 관련 있는 질병상태이다. 최근 지방 산화에 최적의 운동강도가 보고되고 있다. 본 연구는 특정 강도의 지속적인 운동이 인터벌 운동프로그램보다 지방산화와 인슐린 민감성 향상에 매우 효과적일 수 있다는 것을 알아보고자 하였다. 10명의 좌업생활자이면서 비만이지만 건강한 여성 참가자들(33±5 year)이 미리 정해 놓은 운동강도에서 지구성 운동재활 프로그램을 실시하였다. 최대 지방 산화를 얻어낼 수 있는 운동강도로 운동을 4주 실시(Pre-ex)한 후 5주간의 디트레이닝 기간을 두었다. 최대 지방 산화를 얻어낼 수 있는 운동강도의 ± 20%강도로 인터벌 운동을 4주간 추가로 실시(Post-ex)하였다. 운동을 하기 전과 마지막 운동을 한 후 48시간이 경과한 후에 OGTT, VO2max test, steady-state exercise 등을 총 4회 검증하였다. 식이는 운동을 하기 전 매번 관리하였다(50% carbohydrate, 35% fat, and 15% protein; ~2900 kcal/d). 지방산화는 Pre-ex 후 38% (p<0.05) 증가하였지만, Post-ex 이후에는 그렇지 않았다. 인슐린 민감성은 Pre-ex 이후에 23% (p<0.05)로 증가하였다. 그러나 체중, 신체질량지수(BMI), 허리와 힙 비율(WHR)과 % body fat, 그리고 VO2max의 변화는 일어나지 않았다. 그러므로 최대 지방산화를 도출해 낼 수 있는 운동강도에서 지속적인 운동 프로토콜은 운동 중 지질 산화로 지방의 재분배를 증가시킬 수 있으며 일반적인 인터벌 트레이닝 보다 인슐린 민감성을 증가시킬 수 있음을 알 수 있다. 결국, 본 연구에서 지속적인 저강도의 운동은 지질 대사를 향상시키고, 지질 대사의 증가는 비만여성의 인슐린 민감성을 높여 주는 것과 관련이 있는 것으로 사료된다. 따라서 이러한 결과는 건강을 위한 운동재활의 강도를 설정하는 데 있어서 매우 중요한 지표가 될 수 있을 것이다.

자연과학편 : 트레드밀 운동이 당뇨가 유발된 생쥐의 해마 치상회에서 신경세포생성과 단기기억력에 미치는 영향

백성수(SeungSooBaek),김홍(HongKim),김창주(ChangJuKim) 한국체육학회 2006 한국체육학회지 Vol.45 No.5

Diabetes mellitus is one of the most common metabolic disorders in humans. In the present study, the effects of treadmill exercise on short-term memory and cell proliferation in the hippocampal dentate gyrus were investigated via step-down avoidance task and 5-bromo-2'-deoxyuridine(BrdU)-specific immunohistochemistry. Male IRC mice were randomly divided into the four groups: the control group, the streptozotocin(STZ)-injection group, STZ-injection with exercise treatment group, STZ-injection with insulin treatments group. Treadmill exercise was performed 30 min/day in low-intensity for 4 weeks. Single dose of 50 mg/kg BrdU per day was injected intraperitoneally 1 hr before start of exercise for 4 weeks. The mice in all of the groups were trained in a step-down avoidance task and retention time was measured on the 3 days after training session for the determination of short-term memory capability. In the present results, the STZ-injected mice showed decreased neurogenesis in the hippocampal dentate gyrus, wheras treadmill exercise and insulin treatment increased neurogenesis in the STZ-injected mice. The latency in the STZ-injection group was shorter than the control group. Treadmill exercise and insulin treatment significantly increased the latency of mice in the STZ-injection groups. Therefore, it can be suggested that treadmill exercise in the diabetes mellitus may enhance brain function via increasing neurogenesis.