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흰쥐 뇌에서 발육에 따른 cholecystokinin mRNA 발현의 변화
백선용 부산대학교 유전공학연구소 1994 분자생물학 연구보 Vol.10 No.-
Choleystokinin(CCK)is a gastrin-like peptide present in the central nervous system, and its location and concentrations have been examined. CCK immunoreactive neurons are widely distributed throughout the rat central nervous system. In the present study, neurons expressing the CCK geene in developing rats were examined with in situ hybridization histochemistry. 15㎛ thick fresh frozen sections were hybridized with ^35S-labled antisense oligonucleotide to CCK mRNA, and then processes for antoradiography. CCk mRNA appeared at birth in various brain regions, including the cerebral cortex, hippocampus, amygdaloid nuclei, pontine reticular formation, raphe nuclei and lateral parabrachial nucleus. Particularly dense signals were present at birth and in adult rats. Within the cortex and the hippocampus, the signals for CCk mRNA increased with development. Regional differences in the pattern of CCK expression are likely to be related to the development of particular brain functions.
의학 강의의 질 개선을 위한 동영상 수업 분석 및 그 활용도 연구
백선용,이상엽,임선주,이선희,감비성,윤소정,이상수,이정아,이유나 한국의학교육학회 2011 Korean journal of medical education Vol.23 No.4
Purpose: The lecture is a technique for delivering knowledge and information cost-effectively to large medical classes in medical education. The aim of this study was to analyze teaching quality, based on triangle analysis of video recordings of medical lectures, to strengthen teaching competency in medical school. Methods: The subjects of this study were 13 medical professors who taught 1st- and 2nd-year medical students and agreed to a triangle analysis of video recordings of their lectures. We first performed triangle analysis, which consisted of a professional analysis of video recordings, self-assessment by teaching professors, and feedback from students, and the data were crosschecked by five school consultants for reliability and consistency. Results: Most of the distress that teachers experienced during the lecture occurred in uniform teaching environments, such as larger lecture classes. Larger lectures that primarily used PowerPoint as a medium to deliver information effected poor interaction with students. Other distressing factors in the lecture were personal characteristics and lack of strategic faculty development. Conclusion: Triangle analysis of video recordings of medical lectures gives teachers an opportunity and motive to improve teaching quality. Faculty development and various improvement strategies, based on this analysis, are expected to help teachers succeed as effective, efficient, and attractive lecturers while improving the quality of larger lecture classes.
백선용,김수련,황지원,배문경,위희준,최영현,오세옥,김봉선,윤식,배수경,김재봉 대한암예방학회 2006 Journal of cancer prevention Vol.11 No.3
Trichostatin A (TSA) shows a promising therapeutic effect on cancer cells when combined with radiotherapy or chemotherapy. However, so far, little has been reported on the combined treatment with TSA and hyperthermia (heat shock: HS). Here, we examined the effect of TSA/HS on human astrocytoma A172 cells and found that TSA/HS cotreatment effectively induced apoptotic cell death. The molecular mechanism of this effect consists of reduction in the levels of antiapoptotic factors (Bcl-2 and XIAP), Hsp27, and phosphorylated STAT3 (Tyr705), a transcription factor required for survival of A172 cells. Reduction of STAT3 activity resulted in the down-regulation of its taget genes, Bcl-xL and VEGF. In contrast, the level of p53 tumor suppressor was increased by TSA/HS. Therefore, our results show that co-treatment of TSA and HS play a role as an effective inducer of apoptosis in STAT3- dependent tumor cells such as A172 cells. (Cancer Prev Res 11, 205-210, 2006)