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박현선(Hyun Sun Park),천선아(Sun Ah Chun),최설민(Sul Min Choi),김대영(Dae Young Kim),이미경(Mi Kyung Lee),우동준(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 대한약학회 1999 약학회지 Vol.43 No.3
Subacute toxicity study was performed in Sprague-Dawley rats after daily dermal administration of Sangmosu (0.2, 1.0 and 5.0g/kg) for one month. There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and Sangimosu treatment groups. In histopathological examinations, there were some pneumonia in lung tissues at all groups of Sangmosu treatment including control, but it was not considered to be caused by Sangmosu. These results suggest that Sangmosu does not induce any significant subacute dermal toxicities in Sprague-Dawley rats.
김대영(Dae Young Kim),최설민(Sul Min Choi),천선아(Sun Ah Chun),박현선(Hyun Sun Park),우동준(Mi Kyung Lee),이미경(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 한국독성학회 1999 Toxicological Research Vol.15 No.3
Acute subcutaneous toxicity of Sangmosu was investigated in Sprague-Dawley rats. Seven days after administration of Sangmosu (0.078~20 ml/kg), we examined the clinical signs, mortalities, body weight changes, etc. No clinical signs and mortalities were observed in animals. Any significant change of body weights was not observed. These results suggest that LD50 value of Sangmosu was above 20 ml/kg in Sprague-Dawley rats.
최설민(Seul Min Choi),김대영(Dae Young Kim),박요안(Yo An Park),이미경(Mi Kyung Lee),송현수(Hyun Sue Song),권오성(Oh Sung Kwun),임승용(Seung Yong Lim),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김주영(Ju Young Kim),김형식(Hyung Sik Kim 대한약학회 1999 약학회지 Vol.43 No.3
Hair growth effects of Sangmosu have been evaluated in C57BL/6 mice. Animals were topically treated with Sangmosu (50 or 100mcl/mouse) for 40 days on the back of shaved area. Twenty days after treatment, hair growth effects were significantly observed in both female and male mice. There was no sex difference although 30 days after treatment female mice were shown to be more effective at the dose of 50mcl/mouse than males. These data demonstrate that Sangmosu is very effective in hair growth effects in animals and thus it may be applicable to humans.
천선아(Sun Ah Chun),최설민(Sul Min Choi),김대영(Dae Young Kim),박현선(Hyun Sun Park),이미경(Mi Kyung Lee),우동준(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 한국독성학회 1999 Toxicological Research Vol.15 No.3
Eye irritation of Sangmosu was evaluated in New Zealand White rabbits. In ocular irritation test, any injury on iris, conjunctival membrane, and cornea was not observed. No injuries of the ocular mucous membrane were also recorded. These results indicate that Sangmosu was not considered to be irritant in test organs of animals.