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배종우,김채영,정성훈,최용성 대한의학회 2019 Journal of Korean medical science Vol.34 No.25
Neonatal respiratory distress syndrome (RDS) is a disease that is unique to newborn infants. It is caused by a deficiency of pulmonary surfactant (PS), which is usually ready to be activated around the perinatal period. Until RDS was more clearly understood, it was not known why premature infants died from respiratory failure, although pathology revealed hyaline membranes in the alveoli. Surprisingly, the era of PS replacement therapy began only relatively recently. The first clinical trial investigating neonatal RDS was conducted in 1980. Since then, newborn survival has improved dramatically, which has led to significant advances in the field of neonatology. The present comprehensive review addresses PS, from its discovery to the application of artificial PS in newborns with RDS. It also reviews the history of PS in Korea, including its introduction, various commercial products, present and past research, newborn registries, and health insurance issues. Finally, it describes the inception of the Korean Society of Neonatology and future directions of research and treatment.
배종우 대한의사협회 2009 대한의사협회지 Vol.52 No.2
Several advances in premature and neonatal care, such as, development in new drugs and equipments, and improvement of medical skills, have also undoubtedly contributed to the reductions in morbidity and mortality of premature infants during last several decades in Korea. This review was conducted for focusing the development of new medical drug therapy and its clinical application and outcomes for preterm. The details of the artificial pulmonary surfactant replacement therapy for respiratory distress syndrome, indomethacin for patent ductus arteriosus, inhaled nitric oxide therapy for persistent pulmonary hypertension, total parenteral nutrition, and drugs for neonatal resuscitation program were reviewed in this paper.
2006년도 전국 7개 병원 신생아중환자실 입원 현황 및 입원비용 분석
배종우,김기수,김병일,신손문,이상락,임백근,최영륜 대한신생아학회 2009 Neonatal medicine Vol.16 No.1
Purpose : The characteristics of hospitalized patients in neonatal intensive care units (NICUs), including hospitalization costs (HC) and National Health Insurance (NHI) status were studied. Methods : We gathered the following data from 7 hospitals in Korea during 2006: the distribution of patients according to birth weight (BW), and the duration of the hospital stay according to BW and HC. Results : The patients who were admitted to the NICU consisted of high-risk neonates, including low birth weight or premature neonates, which comprised 50% of all neonates admitted to the NICU. The duration of hospitalization was 75-90 days for neonates with BW <1,000 g, 45-60 days for neonates with BW between 1,000 and 1,499 g, and approximately 15 days for neonates with BW between 2,000 and 2,499 g. The portion of the HC covered by the NHI was 77.1%, 22.9% of the total HC was not covered by the NHI (19.5% was included in the list, but not covered by the NHI and 3.4% was not listed, but covered by the NHI). The average total HC per person was 4,360,000 won, and the HC covered and not covered by the NHI were 3,677,000 won and 1,007,000 won, respectively. The mean HC were as follows; 35,000,000 won for a BW <500 g, 18,000,000 won for a BW between 500 and 999 g, 16,000,000 won for a BW between 1,000 and 1,499 g, and 4,200,000 won for a BW between 1,500 and 1,999 g. Conclusion : Not only premature, but also ill neonates were under the care of the NICU. The HC increased as the BW decreased and the hospitalization period increased. The proportion of the patient's financial burden is >25% of the total HC. For this matter, additional NHI is needed.