ADIPOQ Gene Variants Associated with Susceptibility to Obesity and Low Serum Adiponectin Levels in Healthy Koreans

박지완,Jungyong Park,지선하 한국역학회 2011 Epidemiology and Health Vol.33 No.-

OBJECTIVES: This study aimed to measure the association between the adiponectin, C1Q and collagen domain-containing (ADIPOQ) gene variants and obesity in Koreans. METHODS: Three single nucleotide polymorphisms located in the ADIPOQ gene were genotyped in a population-based cross-sectional study of 986 healthy Koreans. Three different case-control groups (i.e. G1, G2, and G3) were defined according to body mass index (BMI) and serum adiponectin levels. Allelic and genotypic associations of this gene with obesity were measured using multivariate logistic regression analyses in each group. RESULTS: The G allele of -11377C>G, a polymorphism located in the promoter region of the ADIPOQ gene (odds ratio (OR), 1.48; 95% confidence interval, 1.13-1.94) and most haplotypes including this allele significantly increased the risk for obesity. However, the OR decreased from 3.98 (G1 group) to 2.90 (G2 group) and 2.30 (G3 group) when a less strict definition of obesity was used. Most haplotypes, including this allele, significantly increased the risk of obesity. The statistical evidence from the GG genotype of -11377C>G (OR, 3.98) and the GT/GT diplotype composed of -11377G>C and +45T>G (OR, 5.20) confirmed the contribution of the G allele toward a predisposition for obesity. CONCLUSION: These results suggest the contribution of the ADIPOQ gene toward susceptibility to obesity in healthy Koreans. The high-risk genotypes and haplotypes identified here may provide more information for identifying individuals who are at risk of obesity.

건설형과 매입형 공공임대주택 주거만족도 영향요인 비교분석

박지완,전이봄,이승일 한국지역개발학회 2023 韓國地域開發學會誌 Vol.35 No.4

Recently, the quality of public rental housing is still in a blind spot, drawing a lot of social attention. In addition, problems such as high vacancy rate, aging, and defect repair appear depending on the type of public rental housing. Therefore, the purpose of this study is to compare and analyze factors affecting residential satisfaction by supply type (construction type, purchase type) of public rental housing using multiple regression analysis. The analysis data classified supply types using the 2019 Public Rental Housing Tenant Panel survey data and compared and analyzed factors affecting residential satisfaction. The study found that the number of household members, age, number of children, residence period, lease deposit burden, and non-disclosure of rental housing were significant variables in the characteristics of residents. Age, gender, and non-disclosure of rental housing were found to be significant variables in residential characteristics in purchased public rental housing, and number of rooms, housing performance, facility conditions, facilities for the disabled and the elderly, and crime prevention conditions were found to affect residential satisfaction. Therefore, the implications of the study are as follows. First, depending on the type of public rental housing, factors affecting residential satisfaction were different. Second, in construction-type public rental housing, the external environment of the house had a great influence on residential satisfaction, but in purchase-type public rental housing, the internal environment of the house had a great influence.

Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans

박지완,Yong Ick Ji,Yoon-Ho Choi,Mi-Yeon Kang,Eunhyun Jung,Se Young Cho,Hee-Youn Cho,Byung Kyu Kang,정유숙,김덕환,Sang Chul Park,박주배 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.11

Long-lived people may have a unique genetic makeup that makes them more resistant than the general population to prevalent age-related diseases; however, not much is known about genes involved in the longevity. To identify susceptibility variants controlling longevity, we performed a high-throughput candidate gene study using 137 Koreans over 90 yr old and 213 young healthy Koreans. We evaluated 463 informative markers located in 176 candidate genes mostly for diabetes mellitus, cardiovascular disease and cancer under five genetic models. We estimated the odds ratios for each allele, genotype, haplotype, and gene-gene interaction using logistic regression analysis. Associations between 13 genes and longevity were detected at a P-value less than 0.01. Particularly, the rs671 (A) allele of the aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2) gene was associated with longevity only in men (OR 2.11, P = 0.008). Four genes, proprotein convertase subtilisin/ kexin type 1 (PCSK1, P = 0.008), epidermal growth factor receptor (EGFR, P = 0.003), paired box 4 (PAX4, P = 0.008), and V-yes-1 Yamaguchi sarcoma viral related oncogene homolog (LYN, P = 0.002) consistently yielded statistical evidence for association with longevity. The findings of the current study may provide a starting point for future studies to unravel genetic factors controlling longevity in Koreans.

만성통증 환자를 위한 집단 수용전념치료의 효과검증: 치료과정변인의 매개효과

박지완,조성근,유경희,조강희,범재원 한국인지행동치료학회 2020 인지행동치료 Vol.20 No.4

This study was conducted to investigate the effects of a group acceptance and commitment therapy(ACT) intervention for patients with chronic pain in comparison to a control group receiving treatment as usual. We also tried to examine whether pain acceptance and pain catastrophizing mediates the outcome of treatment. A total of 22 patients with chronic pain in a university tertiary rehabilitation center located in Daejeon, Korea were included in the study and randomized to either 8 weekly group sessions of ACT or to a control group receiving treatment as usual(TAU). To assess program effectiveness, pain acceptance, pain catastrophizing, depression, anxiety, physical function and mental function were assessed in the four stages (pre, post and follow-up after 1-3 months). As a result of the study, the ACT group showed significantly less pain catastrophizing and anxiety than the TAU group, and the pain acceptance and mental function level were improved. This treatment effect was maintained after 3 months of program termination, and the effect size varied from small size to large size. In addition, mediation analysis showed that pain catastrophizing mediates changes in anxiety and mental function levels. Pain acceptance did not show any mediating effect. These results suggest that ACT is not only more flexible in coping with persistent unpleasant pain experiences, but also is an effective psychological intervention that can successfully adapt to an individual's life despite pain. 이 연구는 만성통증 환자를 대상으로 집단 수용전념치료(Acceptance and Commitment Therapy; ACT)를 실시하여 효과성을 검증하고, 치료과정변인(통증수용, 통증파국화)이 치료결과를 매개하는지 확인했다. 대전광역시 소재 대학병원의 만성통증 환자를 대상으로 의학적 치료를 병행하는 ACT집단과 의학적 치료만을 받는 통제집단에 무선할당을 실시하여 ACT집단 11명, 통제집단 11명 총 22명의 자료가 분석에 포함되었다. ACT 프로그램은 총 8회기로 진행되었으며, 효과검증을 위해 사전, 사후, 종결 후 1․3개월에 통증수용, 통증파국화, 우울, 불안 및 적응기능(신체기능, 정신기능)을 측정했다. 연구 결과, ACT집단이 통제집단에 비해 통증파국화 및 불안 수준이 감소했고, 통증수용 및 정신기능이 향상되었으며 이러한 치료효과는 프로그램 종결 3개월 후에도 유지되었다. 또한 매개분석 결과, 통증파국화가 불안 및 정신기능의 변화를 부분매개하는 것으로 나타났다. 이러한 결과는 ACT가 만성통증 환자에게 효과적인 심리적 개입일 뿐만 아니라 통증파국화의 감소가 불안 및 정신기능과 같은 환자의 기능 개선을 촉진하는 중요한 치료기제임을 시사한다.

광고에서의 역설적 디자인표현에 관한 연구

박지완 한국일러스트레이션학회 2004 일러스트레이션 포럼 Vol.9 No.-

골목상권 매출액 데이터를 활용한 성장-쇠퇴 유형화와 성장상권 영향요인 분석 - 코로나19 전후를 대상으로 -

박지완,전이봄,이승일 한국지역학회 2023 지역연구 Vol.39 No.1

Due to COVID-19, the external activities of urban residents have greatly shrunk, causing a lot of damage to the commercial district, such as a decrease in population and sales. The downturn in commercial districts means the collapse of the infrastructure of the national economy, and can have serious side effects on the local economy and individual lives. Therefore, it is necessary to look at the alley commercial area, which is closely related to the national local economy, and pay attention to the damage and stagnation of the alley commercial area where small business owners are concentrated. The purpose of this study is to classify alley commercial districts into growth commercial districts and decline commercial districts by using commercial sales time series data and DTW time series group analysis for the pre- and post-COVID-19 period. The main findings of the study are as follows. First, using the time series data on commercial sales before and after COVID-19, the alley commercial districts were divided into growth commercial districts and decline commercial districts, and it was confirmed that the distribution of growth commercial districts and decline commercial districts was regionally different. Therefore, it is necessary to actively manage commercial districts in areas where many declining commercial districts are distributed, and it is required to prepare policies for each region in consideration of the spatial distribution of declining commercial districts. Second, during the COVID-19 period, face-to-face essential industries, density of guest facilities, and population density negatively affected the sustainability of commercial districts, which is the opposite of previous studies. This is the result of empirically confirming the specificity of the COVID-19 period and the negative effects of the integrated economy, and can be used as basic data for effective commercial district management and policy preparation in the event of a national disaster in the future. Third, the characteristics of the background of the commercial district had a significant effect on the sustainability of the commercial district, and the negative effect of the attracting facilities inducing population concentration in the background area was found. This suggests that it is necessary to consider the characteristics of the background as well as the inside of the commercial district when establishing policies to revitalize the commercial district and support small business owners in a national disaster situation. 코로나19로 인해 도시민의 외부활동이 크게 위축되면서 인구감소, 매출액 감소 등 상권에 많은 피해가발생하였다. 상권의 침체는 국가경제의 하부구조 붕괴를 의미하며, 지역경제와 개인의 삶에도 심각한 부작용을 초래 할 수 있다. 따라서 국가 지역경제와 밀접한 관계인 골목상권을 살펴보고, 영세한 소상공인이 밀집한 골목상권의 피해와 침체에 주목해야 한다. 이 연구의 목적은 코로나19 전후 기간을 대상으로 상권 매출액 시계열 데이터와DTW 시계열 군집분석을 활용하여 , 골목상권을 성장상권과 쇠퇴상권으로 구분하고 성장상권에 영향을 미치는 요인을 도출하는 것이다. 연구의 주요 결과는 다음과 같다. 첫째, 코로나19 전후 기간의 상권 매출액 시계열 데이터를활용하여 골목상권을 성장상권과 쇠퇴상권으로 구분하였고, 성장상권과 쇠퇴상권의 분포가 지역적으로 차이가 있음을 확인하였다. 따라서 쇠퇴상권이 다수 분포한 지역의 적극적인 상권 관리 정책이 필요하며, 쇠퇴상권의 공간적분포를 고려한 지역별 정책 마련이 요구된다. 둘째, 코로나19 시기에는 대면필수업종과 집객시설 밀도, 인구밀도가 상권 지속성에 부정적 영향을 미쳤으며, 이는 기존의 연구와 반대되는 결과이다. 이는 코로나19 시기의 특수성과 집적경제의 부정적 효과를 실증적으로 확인한 결과이며, 추후 국가재난상황 발생 시 실효성 있는 상권 관리 방안 및 정책 마련의 기초자료로 활용될 수 있다. 셋째, 상권의 배후지 특성이 상권 지속성에 유의미한 영향을 미쳤으며, 배후지의 인구밀집을 유도하는 집객시설의 부정적 효과가 나타났다. 이는 국가재난상황에서 상권 활성화 정책및 소상공인 지원 정책 수립 시 상권 내부뿐만 아니라 배후지 특성도 고려할 필요가 있다는 것을 시사한다.

Genome-Wide Association Analyses on Blood Pressure Using Three Different Phenotype Definitions

박지완,엄상용,신철,조남훈,조윤신,이종영 한국유전체학회 2010 Genomics & informatics Vol.8 No.3

Hypertension is the most prevalent disease worldwide and is itself a risk factor for cerebral, cardiac, and renal diseases. The inconsistency of candidate genes suggested by previous genomewide association studies (GWASs) may be due to not only differences in study design and genetic or environmental background but also the difference in the power of analysis between continuous traits and discrete traits. We analyzed 352,228single nucleotide polymorphisms (SNPs) in 8842 unrelated Koreans obtained from Ansan and Ansung cohorts. We performed a series of GWA analyses using three different phenotype models; young hypertensive cases (278 subjects) versus elderly normotensive controls (680 subjects); the upper 25% (2211 hypertensive cases) versus the lower 25% of the SBP distribution (2211 hypotensive controls); and finally SBP and DBP as continuous traits (8842 subjects). The numbers of young hypertensive cases and elderly normotensive controls were not large enough to achieve genomewide significance. The model comparing the upper 25% subjects to the lower 25% of subjects showed a power that was approximate to that of QTL analysis. Two neighboring SNPs of the ATP2B1 gene, rs17249754 (SBP, p=2.53−10; DBP, p=1.28×10−8) and rs7136259 (SBP, p=1.30×10−9; DBP, p=6.41×10−8), were associated with both SBP and DBP. Interestingly, a SNP of the RPL6gene, rs11066280, revealed a significant genomewide association with SBP in men only (p=3.85×10−8), and four SNPs located near the MAN2A1 gene showed a strong association with DBP only in elderly men aged 60-70 years (e.g., rs6421827, p=4.86×10−8). However, we did not observe any gene variant attaining genomewide significance consistently in the three phenotype models except for the ATP2B1 gene variants. In general, the association signal with blood pressure was stronger in women than in men. Genes identified in GWASs are expected to open the way for prevention, early diagnosis, and personalized treatment of hypertension.

생쥐생체내 석면소체 발생양상에 관한 연구

박지완(Ji Wan Park),정해원(Hai Won Chung) 한국환경보건학회 1989 한국환경보건학회지 Vol.15 No.2

Formation of asbestos bodies in various organs of mouse in course of time after intraperitonea1 injection of three types of asbestoses was studied. Asbestos bodies as well as asbestos fibers were found both in intrapleural organs such as lung and heart and intraperitoneal organs after intraperitonea1 injection of asbestos fiber; this suggested the possibty that asbestos fiber could migrate to the whole body. When asbestos was ir ected intrapleural1y asbestos fiber was found in the lung 15 days after injection but asbestos body was not found till 30 days after injection. The process of asbestos body formation was described.

야외 스트레칭 운동기구 디자인 연구

박지완(Park ji-wan),이정민(Lee Jung-min),이윤혜(Lee Yun-Hae),인석일(In Suck-il) 한국디자인학회 2007 한국디자인학회 학술발표대회 논문집 Vol.- No.-

Maya 기반의 3D 전투 게임 디자인 및 모델링

박지완(Ji-Wan Park),김수열(Su-Yeol Kim),이건주(Gun-Ju Lee),변상준(Byun-Zoon Byun),김윤호(Yoon-Ho Kim) 한국정보기술학회 2014 Proceedings of KIIT Conference Vol.2014 No.5