상피양 혈관내피세포종 1예

박준홍,정현,황규왕,부태성,고은석 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.2

Epithelioid hemangioendothelioma(EH) is a low-grade tumor of vascular endothelial cell origin, which most commonly occur in the lower extremities of middle-aged patients with an equal gender distribution. It may occur on internal organs such as the liver or lung or bones. A 54-year-old woman who had a history of metastatic adenocarcinoma of unknown origin on the right inguinal lymph node, was presented to us because of a 1.0 x 1.0cm-sized and 2 x 2cm-sized two subcutaneous nodule on her right shin. On H & E stain, there were nests of round nucleated, polygonal, vacuolated cells, some of which contained fragmented erythrocytes. Factor VIII related antigen, CD31 was positive. A diagnosis of epithelioid hemangioendothelioma was established based on histologic, immunohistochemical studies. Wide excision was performed. There was no recurrence nor the development of new lesions so far.

<복지>장애인들과 함께 하는 공동체 만들기

박준홍 열린전북 2013 열린전북 Vol.168 No.-

토양생태환경 등급화에 대한 연구동향 및 적용방향

박준홍,기동원 한국지반환경공학회 2006 지반환경 Vol.7 No.3

CIP 법을 이용한 다상 이동경계면에 대한 해석

박준홍,홍희기,김경훈,이상렬 경희대학교 산학협력기술연구원 1998 산학협력기술연구논문집 Vol.4 No.-

The CIP(Cubic-Interpolated propagation) method which can solve together compressible and incompressible fluid is used to calculate multi-phase moving boundary. As test problems, C-CUP(CIP-Combined Unified Proocedure) was applied to a cavity flow and a broken dam, which have been verifid by lots numerical techniques and experiments. In the cavity flow, the distribution velocity calculated by the CIP method shows a good agreement with that of SIMPLE. In the simulation of collapsing process of dam, exact and sharp boundary was obtained on flowing water, although simple boundary conditions are used only on the rectangular region not water-air interface.

지연 임신에 대한 임상적 고찰

박준홍,함형주,고재환,김용봉,이응수,박성관 인제대학교 1996 仁濟醫學 Vol.17 No.3

주산기 이환율 및 사망율과 밀접한 관계가 있는 있는 지연임신은 산과영역에서 중요한 문제로 취급되지만 아직 이의 원인, 처치 및 태아와 모성에 미치는 위험에 관하여서까지도 의견의 일치를 보지 못하고 많은 논란의 대상이 되어오고 있다. 저자는 지연임신이 신생아 및 산모에 미치는 영향을 비교 검토하여 태아 및 모성관리에 임상적 도움이 되는데 본 연구의 목적을 두고 있다. A clinical observation has been made on 50 cases of postterm pregnancies out of 2,823 cases delivered at the Dept. of Obstetrics & Gynecology, Seoul Paik Hospital from April 1, 1993 to July 30, 1996. A total of 370 among 2,580 cases of full term deliveries of 38 to 42 gestational weeks conducted in same period were used as the control group for this study. The results were as follows : 1.The Incidence of postterm pregnancy was 1.77% with the highest incidence occuring in the 26-30 years of age group. The incidence of postterm pregnancy in primipara(2.74% ) was greater than total of multipara(1.59%). 2.In postterm pregnancies, the gestational weeks of 42 was most prevalent(84%) and 43weeks was the next(14%) . 3.The modes of labor onset in postterm pregnancy showed spontaneous 28.00%, induction 52.70%, and cesarean section without labor 20.00%. 4.The incidence of fetal distress was 3.82% and 10.00% in the control group and postterm group respectively. The incidence of fetal distress in the postterm pregnancy was about 2.62 times greater than that of control group and it increased markedly as the gestational weeks were prolonged. 5.The modes of delivery in postterm pregnancy showed : spontaneous vaginal delivery 52.00% vacuum extracted delivery 6.00% cesarean section 42.00% 6.As the indication of cesarean section in postterm pregnancies, the cephalopelvic disproportion was the most prevalent indication and failed induction, fecal distress, previous cesarean section were the next in order. 7.The incidence of large fetus(weight over 4,000gm) was 10% and 3.24% in the postterm group and control group respectively, and postterm group was about 3.08 times greater than that of control group. 8.The incidence of 1min Apgar score under 7 was 14.00% and 8.11% in the postterm group and control group respectively.

Single-color Multitarget Flow Cytometry Using Monoclonal Antibodies Labeled with Different Intensities of the Same Fluorochrome

박준홍,한경자 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.3

Background: We developed a single-color multitarget flow cytometry (SM-FC) assay, a single-tube assay with graded mean fluorescence intensities(MFIs). We evaluated the repeatability of SM-FC, and its correlation with multicolor flow cytometry (MFC), to assess its application as a routine FC assay. Methods: We selected CD19, CD3, CD4, and CD8 as antigen targets to analyze a lymphocyte subset. MFIs were graded by adjusting monoclonal antibody (mAb) volumes to detect several cell populations. Dimly labeled mAb was prepared by decreasing mAb volume and the optimum diluted volume was determined by serial dilution. SM-FC repeatability was analyzed 10 times in 2 normal controls. The correlation between SM-FC and MFC was evaluated in 20 normal and 23 patient samples. Results: CV values (0.8-5.0% and 1.3-4.1% in samples 1 and 2, respectively) acquired by SM-FC with CD3-fluorescein α-isothyocyanate (FITC)dim+CD4-FITCbright and with CD19-FITCdim+CD3-FITCbright showed good repeatability, comparable to that acquired by MFC (1.6-3.7% and 1.0-4.8% in samples 1 and 2, respectively). Excellent correlation was observed between the 2 methods in the 20 normal samples (B cells, T cells, non-Thelper cells, and Thelper cells; r2=0.87, 0.97, 0.97, and 0.98, respectively; P<0.05). There were also linear relationships between SM-FC with CD19-FITCdim+CD3-FITCbright and CD8-PEdim+ CD4-PEbright, and MFC, in the 23 patient samples (B cells, T cells, Tcytotoxic cells, and Thelper cells; r2≥0.98, 0.99, 0.99, and 0.99, respectively; P<0.05). Conclusions: The multicolor, single-tube SM-FC technique is a potential alternative tool for identifying a lymphocyte subset.

Issue Special 극동 러시아 현장을 가다 : 유라시아 물류·에너지 허브 실크로드 익스프레스 “한국까지 연결되길…”

박준홍 포스코경영연구원 2014 CHINDIA Plus Vol.93 No.-

창업가 및 창업기업을 위한 브랜드 개념 모델에 관한 고찰

박준홍 한국디자인리서치학회 2022 한국디자인리서치 Vol.7 No.2

Start-up is a process that requires solving various problems. Among them, developing a brand is very professional and difficult. The purpose of this paper is to study brand concepts for ease of understanding and to consider brand concept models that can be helpful to start-ups. To this end, the concept, definition, hierarchy, and architecture of the brand were studied, and three representative brand identity models were analyzed. The core of the brand delivered to customers was divided into strategic elements and expression elements, and a brand concept model that was easy for founders to understand was devised using a communication model and derived into three strategic elements and three expression elements. The value of study can find in that it changes the start-ups' brand perception. Through research, it is hoped that the brand concept model will help start-ups plan their brands. 창업은 다양한 문제를 해결해야 하는 과정이다. 그중에서도 브랜드를 개발한다는 것은 매우 전문적이며 어려운 일이다. 본 논문은 이해하기 쉽도록 브랜드 개념을 연구하여 창업가에게 도움이 될 수 있는 브랜드 개념 모델을 고찰하는 것을 목적으로 하고 있다. 이를 위해 브랜드의 개념과 정의 그리고 계층과 체계를 연구하였고 대표적인 브랜드 아이덴티티 모델 3가지를 분석하였다. 브랜드가 고객에게 전달되는 핵심을 전략요소와 표현요소로 나누고 커뮤니케이션 모델을 활용하여 창업가가 이해하기 쉬운 브랜드 개념 모델을 고안하고 3가지의 전략요소와 3가지의 표현 요소로 그리고 메시지로서의 슬로건을 도출하였다. 브랜드를 개념적으로만 논의한 것에 연구의 한계가 있지만, 창업가의 브랜드 인식을 변화시킬 수 있다는 것에 연구의 가치를 찾을 수 있다. 연구를 통해 창업가와 창업기업들의 브랜드 기획에 브랜드 개념 모델이 도움 되기를 기대한다.

한국의 안보환경과 군사력 발전

박준홍 대진대학교 통일대학원 2005 統一論叢 Vol.4 No.-

Silk fibroin hydrolysate ameliorates diabetic dyslipidemia in type 2 diabetic model mice

박준홍,Herry Jung,남윤이,김진봉,최농훈,서준교 한국통합생물학회 2013 Animal cells and systems Vol.17 No.5

The antidiabetic properties in silkmaterials, such as silkwormand silk fibroin, have been described in traditional folk medicine. In a previous study, we reported that the silk fibroin hydrolysate (SFH) had a protective effect against glucotoxicity in HIT-15 cells and an antidiabetic effect in a noninsulin-dependent diabetes mellitus (type 2 diabetes, T2DM)mouse model. This study aimed to determine whether SFH ameliorates diabetic dyslipidemia and promotes pancreatic β-cell function in a T2DM animal model (C57BL/KsJdb/db). SFH significantly improved blood glucose levels after 4 weeks of treatment. T2DM animals had a normal serum blood glucose level after 6 weeks of SFH treatment. Hemoglobin A1c (HbA1c) levels were significantly lower in T2DM animals that were treated with SFH for 6 weeks. Glucose tolerance in T2DM animals also significantly improved after 6 weeks of SFH treatment. Furthermore, plasma total cholesterol, high-density lipoprotein cholesterol, nonesterified fatty acid, and triglyceride concentrations significantly decreased in SFH-treated T2DM animals compared to T2DM animals. This result showed that SFH ameliorated diabetic dyslipidemia in the T2DM model mice. Taken together, our results suggest that SFH could be used as a potential agent to treat dyslipidemia in patients who have type 2 diabetes mellitus.