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朴俊明 우석대학교 의과대학 1970 우석의대잡지 Vol.7 No.2
This study was undertaken to know the effect of inoizing radiation on the antibody production of rabbits to non-infective antigens. After irradiation of rabbits with 500 R of cobalt 60, 5㎖ of I¹³¹-labelled 10 per cent sheep red blood cells wire injected, once into vein, and the disappearance of red blood cells in the blood and the distribution in organs were followed with G-M counter. Five ㎖ of 10 per cent sheep red blood cells were also injected in irradiated and non-irradiated rabbits intravenously six times at interval of 4 days and the hemolysin production was titrated by means of complement fixation test. The results obtained were as follows. 1. The optimum labelling time of I¹³¹ for sheep red blood cells was 30 minutes. 2. The disappearance in the blood of I¹³¹-labelled sheep red blood cells in irradiated rabbits was more rapid than in non-irradiated group. 3. The distribution of I¹³¹-labelled red blood cells in organs was high in kidney, lung and brain in irradiated group, and in bone marrow, liver, spleen, muscle and lymph-nodes in non-irradiated group. 4. The hemolysin production was lower in irradiated group than in non-irradiated group in the first half of tie immunizing period, but it was almost the same in both groups in the last half of the immunizing period.