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Collagenase 로 유발한 백서 슬관절의 퇴행성 병변에 관한 형태학적 연구
박창수,노성만,송은규,양동현,박일성,김용욱 대한슬관절학회 1994 대한슬관절학회지 Vol.6 No.1
An osteoarthritis is regarded as a degenerative lesion resulting from mechanical trauma of the joint. The mild injury of the articular cartilage is easily regenerated, but regenerating process is very slow in the severe injury or injury in aged persons. The trauma makes articular cartilage injury by releasing proteolytic enzyme and collagenase. The progress of osteaarthritis are various according to the severity of trauma and age. To investgate eauses of osteoarthritis, histological, immunohistochemical and electron microscopical studies were performed in the young and adult rats which were received intra-articular injection of collagenase. The results were as follows. 1. The amount of cartilage was decreased and hypertrophic zone was replaced to bony tissue. Tidemark was indentified. The above findings was prominent in the groups of 4 weeks and 8 weeks. 2. Immunohistochemical stain for concanavalin A revealed positive reaction in the chondrocytes and matrix, and soybean agglutinin in matrix. Positive reaction for proteoglycan was identified in the chondrocytes of upper zone. 3. In ultrastructural findings, the chondrocytes were frequently arranged in the clusters, degenerated and necrotic chondreeytes were noted especially in the deep zone. The degenerated choadrocytes had a prominent nuclear fibrous laxnina and numerous filaments. They also coatained a dilated or vesiculated roqgh endoplasmic retieulum, lysosome-like bodies, a few of vacuoles and vesicles. Numerous matrix vesicles and lipid globules derived from necrotic chondrocytes were identified in the region adjoining the calcified cartilage. The collagenase made articular cartilage be damaged by disturb the matrix, and osteoarthritis was developed. Aging is suggested to be a causative factor of oseoarthritis.