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박원선,손윤경,고은아,최성우,김나리,최태우,윤현주,조수현,홍다혜,한진 대한약리학회 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.3
We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K+ current (IK) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent EC50 value of 56.1±5.5μg/ml. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating IK without significantly altering the resting membrane potential (IC50 value of APD50: 54.80±2.24, IC50 value of APD90: 57.45±3.47μg/ml). Based on the results, all experiments were performed with 50μg/ml of AIP1. Pre-treatment with the rapidly activating delayed rectifier K+ current (IKr) inhibitor, E-4031 prolonged APD. However, additional application of AIP1 did not reduce APD. The inhibition of slowly activating delayed rectifier K+ current (IKs) by chromanol 293B did not change the effect of AIP1. AIP1 did not significantly affect coronary arterial tone or ion channels, even at the highest concentration of AIP1. In summary, AIP1 reduces APD by activating IKr but not IKs. These results suggest that the natural product AIP1 may provide an adjunctive therapy of long QT syndrome.
朴元善 연세대학교 대학원 1973 延世論叢 Vol.10 No.1
"Kogan", a Korean native broker, is reviewed from the point of view of the legal history. Firstly, in what from the "Kogan" has been developed is discussed in its brief history with the comparison of Orient and Occident. It could be fully seen that the "Kogan" of our country was especially rich in pattern and its existence was indispensable in various commercial or business transactions and bargainings. Secondly, the nature of the "Kogan" was investigated and the difference from the "Kaekju", a factor or a middleman, was studied. It has been known the fact that most of the "Kogan" was belonged to the category of intermediary agent which is a pattern of an agent legally recognized, today. It was seen that the "Kogan" of each different pattern played absolutely the leading role in the circulation process of marchandise in all respect of commercial transactions. It is worthwhile to study further the activities of "Bogtokpang", a house-broker which has been enjoying popularity among the general public in recent years. The comparison of our native "Kogan" system with the broker system corresponding thereto in the Commercial Code Low in force showed many interesting legal correlations between them. Finally, the "Kogan" was discussed in respect of its functions as follows: 1. Indispensability 2. Trust 3. Monopoly 4. Capital capacity