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박완수,Park, Wan-Su KOREAN PHARMACOPUNCTURE INSTITUTE 2009 Journal of pharmacopuncture Vol.12 No.4
목적:이 연구의 목적은 유산균발효애엽 물추출물이 에탄올 등으로 약화된 마우스 대식세포의 NO 생성에 미치는 영향을 조사하는 것이다. 방법:애엽을 유산균으로 발효시켜 시료(AFL)를 만들고 만들어진 시료를 10, 50, 100, 200, 400 ug/mL의 농도로 에탄올, 갈릭산, 아세트아미노펜, 아세트알데히드, 니코틴과 함께 24시간동안 마우스 대식세포에 처리한 후 세포배양액을 채취, NO 생성정도를 측정하여 비교하였다. 결과:1. AFL은 400 ug/mL의 농도에서 갈릭산에 의한 마우스 대식세포의 NO생성억제를 유의하게 회복시켰다. 2. AFL은 200, 400 ug/mL의 농도에서 에탄올에 의한 마우스 대식세포의 NO생성억제를 유의하게 회복시켰다. 3. AFL은 400 ug/mL의 농도에서 니코틴에 의한 마우스 대식세포의 NO생성억제를 유의하게 회복시켰다. 4. AFL은 200, 400 ug/mL의 농도에서 아세트아미노펜에 의한 마우스 대식세포의 NO생성억제를 유의하게 회복시켰다. 5. AFL은 200, 400 ug/mL의 농도에서 아세트알데히드에 의한 마우스 대식세포의 NO생성억제를 유의하게 회복시켰다. 결론:유산균발효애엽추출물(AFL)은 에탄올, 갈릭산, 니코틴, 아세트알데히드, 아세트아미노펜 등에 의해 약화된 대식세포의 NO생성을 회복시킴으로서 다양한 독성물질에 의하여 약화되는 식세포의 항병능력을 회복시키는 면역강화물질로 개발될 수 있을 것이다. Objectives : The purpose of this study is to investigate the effect of Water Extract from Lactobacillus pentosus-fermented ARTEMISIAE ARGI FOLIUM (AFL) on nitric oxide production of mouse macrophage Raw 264.7 cells impaired by various toxicants such as gallic acid, EtOH, nicotine, acetaminophen, and acetaldehyde. Methods : ARTEMISIAE ARGI FOLIUM was fermented with Lactobacillus pentosus and extracted by water. Nitric oxide production of mouse macrophage Raw 264.7 cells was measured by Griess reagent assay. Examined concentrations of AFL were 10, 50, 100, 200, 400 ug/mL. Results : The results of the experiment are as below. 1. AFL at the concentration of 400 ug/mL significantly recovered nitric oxide production which was reduced by gallic acid (100 uM) in Raw 264.7 cells. 2. AFL at the concentration of 200, 400 ug/mL significantly recovered nitric oxide production which was reduced by EtOH (100 uM) in Raw 264.7 cells. 3. AFL at the concentration of 400 ug/mL significantly recovered nitric oxide production which was reduced by nicotine (1mM) in Raw 264.7 cells. 4. AFL at the concentration of 200, 400 ug/mL significantly recovered nitric oxide production which was reduced by acetaminophen(2 mM) in Raw 264.7 cells. 5. AFL at the concentration of 200, 400 ug/mL significantly recovered nitric oxide production which was reduced by acetaldehyde (200 uM) in Raw 264.7 cells. Conclusions : AFL could be supposed to have the immune-enhancing activity related with nitric oxide production of macrophage impaired by various toxicants.
박완수 대한한의학회 2012 대한한의학회지 Vol.33 No.4
Objectives: The purpose of this study was to investigate effects of Red Ginseng-Ejung-tang Water Extract (ER) on cytokine production in RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS). Methods: Levels of various cytokines such as interleukin (IL)-6, IL-10, IL-2, IL-12p70, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-2, keratinocyte-derived chemokine (KC), tumor necrosis factor (TNF)-alpha, granulocyte macrophage colony-stimulating factor (GM-CSF) were measured by high-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. Results: ER significantly decreased levels of IL-6, IL-10, IL-2, IL-12p70, VEGF, and MCP-1 for 24 hrs incubation at the concentrations of 25, 50, and 100 ㎍/mL in LPS-induced RAW 264.7 cells (P < 0.05). But ER did not exert significant effects on production of MIP-2, KC, TNF-α, and GM-CSF in LPS-induced RAW 264.7 cells. Conclusions: These results suggest that ER has an anti-inflammatory property related with its inhibition of cytokine production in LPS-induced macrophages. Objectives: The purpose of this study was to investigate effects of Red Ginseng-Ejung-tang Water Extract (ER) on cytokine production in RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS). Methods: Levels of various cytokines such as interleukin (IL)-6, IL-10, IL-2, IL-12p70, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-2, keratinocyte-derived chemokine (KC), tumor necrosis factor (TNF)-alpha, granulocyte macrophage colony-stimulating factor (GM-CSF) were measured by high-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. Results: ER significantly decreased levels of IL-6, IL-10, IL-2, IL-12p70, VEGF, and MCP-1 for 24 hrs incubation at the concentrations of 25, 50, and 100 ㎍/mL in LPS-induced RAW 264.7 cells (P < 0.05). But ER did not exert significant effects on production of MIP-2, KC, TNF-α, and GM-CSF in LPS-induced RAW 264.7 cells. Conclusions: These results suggest that ER has an anti-inflammatory property related with its inhibition of cytokine production in LPS-induced macrophages.
Pharmacometric models simulation using NONMEM, Berkeley Madonna and R
박완수 대한임상약리학회 2017 Translational and Clinical Pharmacology Vol.25 No.3
In this tutorial, we introduce a differential equation simulation model for use in pharmacometricsinvolving NONMEM, Berkeley Madonna, and R. We report components of the simulation codeand similarities/differences between software, rather than how to use each software. Depending onthe purpose of the simulation, an appropriate tool can be selected for effective communication.
6자유도를 고려한 회전익 항공기 착륙장치의 동특성 해석
박완수,황재업,현영오,황재혁,배재성,김태욱,Park, Wansoo,Hwang, Jaeup,Hyun, Youngho,Hwang, Jaehyuk,bae, Jaeseoung,Kim, Taewook 항공우주시스템공학회 2008 항공우주시스템공학회지 Vol.2 No.1
In this paper, full body modeling and analysis of nose and main landing gear's characteristics of a helicopter are performed using the dynamics analysis program ADAMS. Also, when land limiting about helicopter body's degree-of-freedom, compared the characteristics. In the case of helicopter, because there are a lot of dangerous missions under flight condition that is disadvantageous than fixed wing airplane, need more detailed research for a helicopter.