교통문화지수 실태조사 개선방안에 관한 연구

박신형,이주용,권오훈,박신형,김주영 한국ITS학회 2019 한국ITS학회 학술대회 Vol.2019 No.04

도심부 연속류 구간 무인단속카메라 설치 효과분석에 관한 연구 - 대구광역시를 중심으로 -

박신형,권오훈,박신형 한국ITS학회 2017 한국ITS학회 학술대회 Vol.2017 No.04

비모수 회귀분석을 이용한 실시간 통행시간 예측 기법 개발 및 평가 (서울시 버스를 중심으로)

박신형,정연정,김창호 대한교통학회 2006 대한교통학회지 Vol.24 No.1

2004년 7월, 서울시는 대중교통 이용률을 높이고, 여러 교통 문제를 해소 또는 완화하기 위해 버스 중심의 대중교통체계로 대대적인 개편을 단행하였다. 중앙버스전용차로제가 확대 시행되었고, 광역, 간선, 지선, 순환의 네 가지 형태로 노선을 구분, 정비하였으며, 통합거리비례요금제 방식을 도입하였다. 이와 함께 BMS(Bus Management System)의 구축으로 서울시 버스 시스템 전반에 대한 관리 및 제어가 가능해 짐으로써 버스 이용자들에게 보다 신속, 정확하게 실시간 정보를 제공할 수 있게 되었다. 본 연구에서는 이러한 서울시의 새로운 대중교통체계에 맞추어, 선행연구를 통해 정립된 최적경로 탐색기법들을 적용하여 대중교통 최적경로를 산출하고, 기존의 여러 통행시간예측모형 비교를 통해 선정된 비모수 회귀분석 기법을 적용하여 주간선 및 보조간선 도로망에서의 대중교통 데이터에 기초한 통행시간 예측 응용 프로그램을 구현하였다. 그리고 구현된 프로그램의 정확성과 신속성 평가를 통해 실제 시스템에서의 적용가능성과 그 방안들을 제시하였다. Since the 1st of July, 2004, the public transport system of the Seoul metropolitan area has been rearranged. In the new system, bus lines are divided into 4 classes—wide area, arterial road, branch, and rotation lines with renewed fare system based on the total distance travelled. Since central control center known as the Bus Management System (BMS) integrates the entire system operation, it now becomes feasible to collect travel information and provide it to the users scientifically and systematically. The purpose of this study is to forecast transit travel time using real-time traffic data coming from both buses and subway. This is significant contribution since provision of real-time transit information and easy access to it would most likely boost the use of mass transit system, alleviating roadway congestion in the metropolitan area.

청피 에탄올 추출물이 스트레스성 카테콜아민으로 유도한 간암세포의 전이를 억제하는 효과 및 기전 연구

박신형 한의병리학회 2024 동의생리병리학회지 Vol.38 No.1

Previous studies have highlighted the pivotal role of the β-adrenergic receptor (β-AR) signaling pathway in stimulating cancer metastasis induced by chronic stress. According to the theory of traditional Korean medicine, chronic stress can induce Qi stagnation. Based on the traditional role of premature citrus unshiu peel in moving Qi, we hypothesized that an ethanol extract of premature citrus unshiu peel (EPCU) can attenuate chronic stress-induced cancer progression. In this study, we investigated the potential role of EPCU on modulating the adrenergic agonists-induced metastatic properties of liver cancer cells. Our findings revealed that adrenergic agonists, including norepinephrine (NE), epinephrine (E), and isoproterenol (ISO), augmented the migratory capacity of Hep3B human hepatocellular carcinoma cells, which was completely abrogated by EPCU treatment in a concentration-dependent manner. Consistently, EPCU inhibited the E-induced invasive property of Hep3B cells in a dose-dependent manner. These results suggest that EPCU efficiently attenuates adrenergic agonists-induced metastatic abilities of liver cancer cells. As a molecular mechanism, EPF suppressed the phosphorylation of major components of β-AR signaling pathway, including Src, signal transducer and activator of transcription 3 (STAT3) and ERK, induced by E treatment. Taken together, our results demonstrate that EPCU impedes the adrenergic agonists-driven metastatic potential of cancer cells by inhibiting β-AR signaling pathway. This study provides basic evidence supporting the probable use of premature citrus unshiu peel to prevent metastasis in liver cancer patients under chronic stress.

Comparison of Electron and X-Ray Beams for Tumor Bed Boost Irradiation in Breast-Conserving Treatment

박신형,김재철 한국유방암학회 2013 Journal of breast cancer Vol.16 No.3

Purpose: This study aimed to compare the dosimetric profiles of electron beams (EB) and X-ray beams (XB) for boosting irradiation in breast cancer patients who underwent breast-conserving surgery and postoperative radiotherapy. Methods: For 131 breast cancer patients who underwent breast-conserving surgery, we compared plans for EB and XB boost irradiation after wholebreast irradiation. The organs at risk (OAR) included the cardiac chambers, coronary arteries, ipsilateral lung, and skin. The conformity index (CI), inhomogeneity index (IHI), and dose-volume parameters for the planning target volume (PTV), and OAR were calculated. Postradiotherapy chest computed tomography scans were performed to detect radiation pneumonitis. Results:XB plans showed a significantly better CI and IHI for the PTVs,compared to the EB plans. Regarding OAR sparing, the XB reduced the high-dose volume at the expense of an increased Purpose: This study aimed to compare the dosimetric profiles of electron beams (EB) and X-ray beams (XB) for boosting irradiation in breast cancer patients who underwent breast-conserving surgery and postoperative radiotherapy. Methods: For 131 breast cancer patients who underwent breast-conserving surgery, we compared plans for EB and XB boost irradiation after wholebreast irradiation. The organs at risk (OAR) included the cardiac chambers, coronary arteries, ipsilateral lung, and skin. The conformity index (CI), inhomogeneity index (IHI), and dose-volume parameters for the planning target volume (PTV), and OAR were calculated. Postradiotherapy chest computed tomography scans were performed to detect radiation pneumonitis. Results:XB plans showed a significantly better CI and IHI for the PTVs,compared to the EB plans. Regarding OAR sparing, the XB reduced the high-dose volume at the expense of an increased low-dose volume. In 33 patients whose radiation fields includednipples, IHI was higher in the EB plans, whereas the presence ofa nipple in the radiation field did not interfere with the XB. EBtreatedpatients developed more subclinical radiation pneumonitis. Conclusion: XB plans were superior to EB plans in terms ofPTV coverage (homogeneity and conformity) and high-dose volumesparing in OAR when used as boost irradiation after breastconservingsurgery. A disadvantage of the XB plan was an increasedlow-dose volume in the OAR, but this was offset by theincreased electron energy. Consequently, tailored plans with eitherXB or EB are necessary to adapt to patient anatomic varianceand tumor bed geometric properties.

톳 메탄올 추출물에 의한 인체 폐암 세포의 Apoptosis 유발

박신형,신동역,엄현섭,지규용,최영현 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.2

Hizikia fusiforme, a brown alga, has been reported to possess a wide range of beneficial activities including immuno-modulating, anti-oxidants, anti-coagulants, and anti-carcinogenic effects. According to recent studies, H. fusiforme can inhibit the growth of cancer cell by inducing apoptosis in a certain cancer lines in vitro. However, the molecular mechanism how it acts as an inducer of apoptosis is not fully understood. In this study, we investigated the apoptotic effects of H. fusiforme methyl alcohol extracts (MEHF) in A549 and NCI-H460 human lung carcinoma cell lines. It was shown that MEHF induced the cell growth inhibition in a dose-dependant manner and it was more significant in NCI-H460 cells. There also appeared increased sub-G1 phase DNA content, chromatin condensation, as well as DNA fragmentation in MEHF-treated cells, which are indicators of apoptosis. MEHF activated the caspase-8via up-regulating Fas, FasL and DR5 expression and cleavage of Bid protein. MEHF also up-regulated the pro-apoptotic Bax levels and down-regulated anti-apoptotic Bcl-xL expression, which was associated with the loss of mitochondrial membrane potential (MMP) and activation of caspase-9 and caspase-3. Taken together, these findings suggest that H. fusiforme might be useful for clinical application to treat human lung cancer. (Cancer Prev Res 15, 164-171, 2010)

Incidences of Deep Vein Thrombosis and Pulmonary Embolism after Total Knee Arthroplasty Using a Mechanical Compression Device with and without Low-Molecular-Weight Heparin

박신형,안중현,박용복,이선근,임수재 대한슬관절학회 2016 대한슬관절학회지 Vol.28 No.3

purpose: To investigate the incidence of thromboembolic events and complications related to bleeding after total knee arthroplasty (TKA) with a mechanical compression device alone or in combination with low-molecular-weight heparin (LMWH).Materials and Methods: A total of 489 TKA patients (776 knees) were retrospectively reviewed for the incidence of thromboembolic events and complications related to bleeding. While 233 patients (354 knees) were treated with a mechanical compressive device without LMWH, 256 patients (422 knees) were treated with the mechanical compressive device along with LMWH. results: The incidences of deep vein thrombosis (DVT) and pulmonary embolism (PE) were 15 of 375 knees (4.0%) and 5 of 375 knees (1.3%), respectively, in the group that used only a mechanical compressive device, and 14 of 401 knees (3.4%) and 5 of 401 knees (1.2%), respectively, in the group that used the mechanical compressive device with LMWH. There was no significant difference between the two groups (p=0.125 and p=0.146, respectively). The postoperative hemovac drainage amount was 635±57 mL in the group with a mechanical compressive device only and 813±84 mL in the group with the device and LMWH; therefore, the amount of drainage was significantly greater in the latter group (p=0.013).conclusions: Mechanical compression alone for prophylaxis against DVT and PE after TKA can be an attractive option in Korean patients.

소집단 독서교육 프로그램이 유아의 사회적 태도와 사회적 기술 증진에 미치는 효과

박신형 성균관대학교 生活科學硏究所 2003 生活科學 Vol.6 No.-

빅데이터 기반 실시간 교통흐름 분석 및 유고상황 대응체계 알고리즘 개발

박신형 한국ITS학회 2019 한국ITS학회 학술대회 Vol.2019 No.04

태블릿PC 기반의 고속도로 교통사고 조사기술 개발

박신형,이성관 한국ITS학회 2012 한국ITS학회 학술대회 Vol.2012 No.1