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라우릴황산나트륨과의 Roll 혼합에 의한 메페남산의 용출성 개선
박성연,서성훈,Park, Seong-Yeon,Seo, Seong-Hoon 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.4
Dissolution rate of practically insoluble mefenamic acid was improved by roll mixing with sodium lauryl sulfate (SLS) or polyvinylpyrrolidone (PVP). The dissolution rate of the drug roll mixtures with SLS was superior to that of roll mixtures with PVP. The maximal dissolution rate was found in the roll mixtures system with SLS content of 60%. The dissolution rate of mefenamic acid roll mixtures with SLS content of 60% reached to the maximum value after 10 min of roll mixing. The transport of roll mixtures with SLS across rat jejunum was studied by the perfusion method using everted rat jejunum in vitro. The absorption rate of roll mixtures was superior to that of mefanamic acid.
LNG 선의 1차 방벽 주름부의 내압 성능 분석을 위한 잔류 응력 및 기하학적 형상에 관한 연구
박성연(Seong Yeon Park),김성수(Seong Su Kim) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
The primary barrier of a liquefied natural gas (LNG) carrier generally has a corrugated shape, so as to withstand thermal shrinkage at cryogenic temperatures. Studies have been performed to improve the performance of the primary barrier through structural analysis. However, when analyzing the pressure-resisting capability of the corrugation, previous studies have not considered the residual stress generated during the forming process of the corrugation. In this work, the pressure-resisting capabilities of the corrugation were evaluated by considering the residual stress generated during the forming process of the corrugation and buckling mode considered through a linear buckle analysis using finite element analysis. Universal hydraulic test equipment was developed for measuring the pressure-resisting capabilities of corrugations of various sizes. By comparing the analytical results from the experiments, it was confirmed that the pressure-resisting capability of the corrugation decreased by 16% when the residual stress and initial buckling mode were considered simultaneously.