찰가자미, Micromus achne 자어의 성장과 발달에 따른 소화효소 활성의 변화

박상언(Sang Un Park),임한규(Han Kyu Lim),한현섭(Hyon-Sob Han),이종하(Jong Ha Lee),임영수(Young Su Lim),이종관(Jong Kwan Lee),이상민(Sang Min Lee) 한국수산과학회 양식분과 2003 韓國養殖學會誌 Vol.16 No.4

증례 : 좌측 천부 대퇴동맥을 침범하여 좌측 슬하 절단술을 받아야 했던 Churg-Strauss 증후군 1예

박상언 ( Sang Un Park ),오성욱 ( Sung Ook Oh ),박신실 ( Sin Sil Park ),오미정 ( Mi Jung Oh ),권남희 ( Nam Hee Kwon ),서연림 ( Yeon Lim Suh ),최동철 ( Dong Chull Choi ) 대한내과학회 2007 대한내과학회지 Vol.72 No.1S

Fisher Information in Statistical Theory and Models

박상언(Sang Un Park) 연세대학교 경제연구소 1996 延世經濟硏究 Vol.3 No.2

임신중절에 대한 종교 생명윤리 담론의 정당화 구조와 성격 -한국의 기독교와 불교를 중심으로

박상언 ( Sang Un Park ) 한국종교문화연구소 2009 종교문화비평 Vol.15 No.15

암환자의 사전연명의료의향서 지식과 좋은 죽음 인식이 연명의료중단 태도에 미치는 영향

박상언(Sang-Un Park),강영실(Yong-Sil Kang) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.2

본 연구는 암환자의 사전연명의료의향서 지식, 좋은 죽음 인식이 연명의료중단 태도에 미치는 영향을 파악하여 암환자의 연명의료중단의 자기결정 활성화를 위한 간호 중재프로그램 개발 기초 자료를 제공하고자 시행되었다. 외래 또는 입원치료를 받는 성인 암환자 167명을 대상으로, 2019년 9월 15일부터 2020년 3월 30일까지 자료수집을 하였다. 수집된 자료의 통계분석은 SPSS 21.0을 이용하여 평균과 표준편차, t-test, ANOVA, Pearson 상관계수, 다중회귀분석으로 하였다. 연구결과, 대상자의 사전연명의료의향서 지식은 1점 만점에 0.74±0.21점, 좋은 죽음 인식은 4점 만점에 2.87±0.42점, 연명의료중단 태도는 5점 만점에 3.46±0.49점이었다. 본 연구결과 연명의료중단 태도는 사전연명의료의향서 지식, 좋은 죽음 인식과 정적 상관관계로 나타났으며, 영향을 미치는 변인은 사전연명의료의향서 지식, 좋은 죽음인식, 가족과 연명의료중단 논의 여부로 나타났고, 설명력은 16.0%이었다(F=10.355, p<.001). 따라서, 암환자의 연명의료중단 태도 향상을 위해 사전연명의료의향서 지식 및 좋은 죽음 인식을 높일 수 있는 프로그램 개발이 필요하며, 가족과 환자의 사전 논의에 도움을 줄 수 있는 중재 방안이 필요하다. This study was conducted to identify the effects of knowledge of Advance Directives (AD) and the patient"s perception of a peaceful death on their attitude toward the withdrawal of life-sustaining treatment and to provide basic data for the development of a nursing intervention program for activating self-determination in the withdrawal of life-sustaining support of patients. The subjects were 167 adult cancer patients who received outpatient or inpatient treatment, from September 15, 2019, to March 30, 2020. The data was analyzed by mean, standard deviation, t-test, ANOVA, Pearson"s correlation coefficient, and multiple regression by using SPSS 21.0. From the results, it was observed that the knowledge of AD was 8.87±2.46 out of 12, perception of a peaceful death was 2.87±0.42 out of 4, and attitude toward withdrawal of life-sustaining treatment was 3.46±0.49 out of 5. There was a positive correlation between knowledge of AD, perception of a peaceful death, and their attitude toward withdrawal of life-sustaining treatment. The influencing variables were the knowledge of AD, perception of a peaceful death, discussion with family on withdrawal of life-sustaining treatment, and explanation power was 16.0% (F=10.355, p<.001). Therefore, it is necessary to develop a program that would improve the perception of a peaceful death, increase the knowledge of AD to improve the patients" attitude toward the withdrawal of life-sustaining treatment. An intervention to assist a discussion between the patients and their families in advance would also be useful.

딥러닝 중심의 자연어 처리 기술 현황 분석

박상언 ( Park Sang-un ) (사)한국빅데이터학회 2021 한국빅데이터학회 학회지 Vol.6 No.1

자연어 처리는 최근 기계학습 및 딥러닝 기술의 발전과 적용으로 성능이 빠르게 향상되고 있으며, 이로 인해 활용 분야도 넓어지고 있다. 특히 비정형 텍스트 데이터에 대한 분석 요구가 증가함에 따라 자연어 처리에 대한 관심도 더욱 높아지고 있다. 그러나 자연어 전처리 과정 및 기계학습과 딥러닝 이론의 복잡함과 어려움으로 인해 아직도 자연어 처리 활용의 장벽이 높은 편이다. 본 논문에서는 자연어 처리의 전반적인 이해를 위해 현재 활발히 연구되고 있는 자연어 처리의 주요 분야와 기계학습 및 딥러닝을 중심으로 한 주요 기술의 현황에 대해 살펴봄으로써, 보다 쉽게 자연어 처리에 대해 이해하고 활용할 수 있는 기반을 제공하고자 한다. 이를 위해 인공지능 기술 분류체계의 변화를 통해 자연어 처리의 비중 및 변화 과정을 살펴보았으며, 기계학습과 딥러닝을 기반으로 한 자연어 처리 주요 분야를 언어 모델, 문서 분류, 문서 생성, 문서 요약, 질의응답, 기계번역으로 나누어 정리하고 각 분야에서 가장 뛰어난 성능을 보이는 모형들을 살펴보았다. 그리고, 자연어 처리에서 활용되고 있는 주요 딥러닝 모형들에 대해 정리하고 자연어 처리 분야에서 사용되는 데이터셋과 성능평가를 위한 평가지표에 대해 정리하였다. 본 논문을 통해, 자연어 처리를 자신의 분야에서 다양한 목적으로 활용하고자 하는 연구자들이 자연어 처리의 전반적인 기술 현황에 대해 이해하고, 자연어 처리의 주요 기술 분야와 주로 사용되는 딥러닝 모형 및 데이터셋과 평가지표에 대해 보다 쉽게 파악할 수 있기를 기대한다. The performance of natural language processing is rapidly improving due to the recent development and application of machine learning and deep learning technologies, and as a result, the field of application is expanding. In particular, as the demand for analysis on unstructured text data increases, interest in NLP(Natural Language Processing) is also increasing. However, due to the complexity and difficulty of the natural language preprocessing process and machine learning and deep learning theories, there are still high barriers to the use of natural language processing. In this paper, for an overall understanding of NLP, by examining the main fields of NLP that are currently being actively researched and the current state of major technologies centered on machine learning and deep learning, We want to provide a foundation to understand and utilize NLP more easily. Therefore, we investigated the change of NLP in AI(artificial intelligence) through the changes of the taxonomy of AI technology. The main areas of NLP which consists of language model, text classification, text generation, document summarization, question answering and machine translation were explained with state of the art deep learning models. In addition, major deep learning models utilized in NLP were explained, and data sets and evaluation measures for performance evaluation were summarized. We hope researchers who want to utilize NLP for various purposes in their field be able to understand the overall technical status and the main technologies of NLP through this paper.

정위성방광대치술을 시행받은 방광암 환자의 기능적 결과 및 삶의 질

박상언(Sang Un Park),조강수(Kang Su Cho) 대한비뇨기종양학회 2015 대한비뇨기종양학회지 Vol.13 No.1

Radical cystectomy is the golden standard treatment for muscle-invasive bladder cancer. Urinary diversion is the prerequisite procedure after cystectomy and various type of urinary diversion has been introduced. Urinary diversion carries surgical morbidities, postoperative complications in terms of urinary function and sexual function, and issues for quality of life, which are important considerations for selecting urinary diversion. Ileal conduit urinary diversion and orthotopic bladder substitution have been regarded as the representative urinary diversion after radical cystectomy. There have been great efforts to compare the functional outcomes and quality of life between these two types of urinary diversion. Although orthotopic bladder substitution seems to a more natural and desirable urinary diversion, the currently available evidence is insufficient to draw a conclusion that orthotopic bladder is an absolutely superior form of urinary diversion. However, the vast majority of studies demonstrated that orthotopic neobladder urinary diversion shows at least equal or a marginally better quality of life scores compared to ileal conduit diversion. The favorable outcomes of orthotopic neobladder would be more pronounced especially when considering relatively young and healthy patients.

19세기 미국 사회의 의학 담론과 몸의 성격

박상언(Sang Un Park) 한국종교학회 2018 宗敎硏究 Vol.78 No.2

The purpose of this paper is to discuss the health reform movement formed by Samuel Thomson and Sylvester Graham in early 19th century America, which tried to acquire cultural hegemony in the sphere of health care and embraced a unique religio-medical ideology and understanding of the nature of the body. In the process of analyzing the movement, I find that the health reformers Thomson and Graham tried to acquire cultural hegemony in the area of health care through writings, public lectures, and the formation of various organizations. However, while the health reform movement had the singular goal of achieving an ideal society, it was actually divided internally into two camps with regard to the source of medical knowledge and the strategic goal of the movement. Concerning the former, Thomson emphasized experience-based therapies based on folk remedies and botanic medicine, while in Graham’s case, medical knowledge was to be derived largely from objective science; i.e. ‘physiology’. With regard to the movement’s strategic goal, Thomson wanted the public to become ‘healers’ themselves by learning about practical remedies and developing their own medical expertise, while Graham envisioned perfect citizens living in optimum physical and mental health based on a clear dietetic regime and sound physiological principles. He also placed greater emphasis on the positive role of women in domestic life.

18세기 영국사회의 종교와 의학의 상호간섭 현상에 관한 분석 : 존 웨슬리의 종교적 의학 관념을 중심으로

박상언 ( Park¸ Sang Un ) 동국대학교 영어권문화연구소 2015 영어권문화연구 Vol.8 No.1

Today, in the civilization societies, illness and health problems are controlled by scientific medicine. However, the situation was different in 18th-century British society. There were regular physicians and irregular hearers competing in the medical market. For the poor, it was a serious problem that the medical treatments of regular physicians were practiced for upper class usually, even their effects were weak. Therefore, it was natural that the poor searched for cheap and efficacious remedies. John Wesley, Anglican minister, tried to provide medical information for the popular by publishing medical texts and to practice medical treatments for them. In this context, I examine the phenomenon of mutual interference between religion and medicine in 18^th century British society focusing on the religio-medical concept of John Wesley. For the purpose, I examine how John Wesley tried to form Christianity's identity as a rational religion in relation to the treatment of disease, while reshaping a healing as an important aspect of religion with the knowledges of modern science. And I show the context in which John Wesley practiced medical treatments and published medical texts for the public in 18^th century British society.

염색체 과배수성이 대장암 세포의 생존능에 미치는 영향

박상언 ( Sang Un Park ),최은숙 ( Eun Sook Choi ),장연실 ( Yeon Sil Jang ),홍승희 ( Seung Hee Hong ),김인후 ( In Hoo Kim ),장동경 ( Dong Kyung Chang ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.3

Background/Aims: Tetraploid cells are frequently observed in the inflamed mucosal epithelial cells of the patients with Barrett`s esophagus or chronic ulcerative colitis. Polyploidy often occurs during cell fusion, abortive cell cycle, and endoreplication. Most tetraploid cells are engaged to apoptotic pathway, but some remaining stable tetraploid cells consequently cause aneuploidization and chromosomal instability. We investigated whether tetraploid cells could acquire survival advantage and hold a dominant position for natural selection. Methods: We established tetraploid cell line (HCT116GH) from parental diploid colorectal cancer cell line (HCT116) via PEG-mediated cell fusion and compared its cell viability, cell cycle response and apoptotic fractions responded to H2O2 with diploid HCT116 and p53 suppressed HCT116/H6 cell lines. Results: Using MTT assay, plating efficiency and clonogenicity, we evaluated the survival of each cell line. Tetraploid cell line HCT116GH demonstrated an 83 fold greater resistance to 100 μM H2O2 than the parental diploid HCT116, and 6 fold greater than even the p53 negative diploid HCT116/E6. Cellular sensitivity, G2/M arrests, and apoptotic proportion were observed less in response to H2O2 in HCT116GH compared with HCT116 and HCT116/E6. HCT116GH expressed lower level of p53 and p21 than diploid HCT116. Conclusions: Stable tetraploid cell lines showed enhanced viability in comparison to parental diploid cell lines. The enhanced viability observed in tetraploidization surpassed that from downregulation of p53. Frequent appearance of tetraploid cells in stressful condition can be caused by natural selection owing to their enhanced viability and may consequently contribute to cancer cell transformation.(Korean J Gastroenterol 2011;57:150-157)