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정요찬(Yo Chan Jeong),윤효인(Hyo In Yun),조명행(Myung Haing Cho),박병권(Byung Kweon Park),박일현(Il Hyun Park),김복환(Bok Hwan Kim),송동호(Dong Ho Song) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.3
The purpose of this study was to determine pharmacokinetic parameters and tissue distribution pattern of urinary trypsin inhibitor(UTI) in Sprague-Dawley rats. Na^(125)I was conjugated to UTI to make ^(125)I-UTI and the concentrations were determined by γ counter. With the aid of nonlinear least-square regression analysis for i.v. bolus injection of 1,000 unit UTI including ^(125)I-UTI, the temporal concentration curves were best fitted by 2-compartment open model. The distribution phase half-life was 0.39±0.02 hours whereas the elimination half-life was 12.99±1.05 hours in male rats. The volume of distribution and total body clearance in male rats were 0.28±0.01 l/kg and 83.16±1.15 ml/kg/h, respectively. We could not find any difference of pharmacokinetic parameters of UTI between male and female rats. UTI were distributed widely in rat organs. In both male and female rats, the kidney was the highest distributed organ. Amount of UTI in 24 hour cumulative urine in male rats was 36.22±8.74% and that in 48 hours was 43.32±10.55%. Excretion via feces was very scanty, with the 24 hours cumulative amount being only 2.76±0.97%. This data suggest the main excretion route of UTI is urine.
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한국산 개에서 Halothane 마취하에 Sodium Nitroprusside 혹은 Esmolol 을 사용한 유도저혈압시에 혈역학적 변화
박병권,손주태,이헌근 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.28 No.3
The deliberate hypotension with esmolol or sodium nitroprusside(SNP) was provided subsequently in random order with six dogs. Anesthesia was maintained with 0.8 vol% halothane, end-tidal, in N₂O/O₂, 50: 50, with vecuronium. Mean arterial pressure was reduced 30-35% to 70 mmHg, with use of SNP or esmolol. Mean arterial pressure, heart rate, mean pulmonary arterial pressure, arterial blood gas analysis, and cardiac output were measured both prior to the deliberate hypotension and at 70 mmHg of mean arterial pressure induced with esmolol or SNP. The following results were observed; 1) The mean doses required were 725±250 ㎍/kg/min in esmolol and 12±2 ㎍/kg/min in SNP. 2) Esmolol was associated with a decrease in cardiac output (from 2.13±0.23 to 1.27±0.23 L/min), in heart rate (from 128±14 to 91±11/min), and an increase in central venous pressure (from 9.2±3.27 to 11.60±3.21 mmHg)(p$lt;0.05). 3) SNP decreased systemic vascular resistance from 41111±484 to 2175±451 dynessec/㎤ (P$lt;0.05), trended to increte. 4) A change in arterial blood gas analysis before and during deliberate hypotension with esmolol or SNP was not significant. As to mechanism of hypotensive effect, SNP caused decrease in systemic vascular resistance by 47% but esmolol significantly reduced cardiac output by 40% and heart rate by 29%. The result of present study suggests that when moderately deliberate hypotension with only esmolol was done, the potential for marked myocardial depression must be recognized. The differences in pharmacologic properties for the different hypotensive agents suggest that combinations of these agents may be provide a pharmacologic profile superior to either agent alone.
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돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학
윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.
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