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1980-2019년 기간 동안 소아청소년 알레르기질환에서 항원 감작의 변화
정재화 ( Jae Hwa Jung ),김가은 ( Ga Eun Kim ),박미르 ( Mireu Park ),김수연 ( Soo Yeon Kim ),김민정 ( Min Jung Kim ),이용주 ( Yong Ju Lee ),김윤희 ( Yoon Hee Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ) 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.4
Purpose: Allergen sensitization is constantly changing, and understanding these changes can help manage and prevent allergic diseases. This research analyzed and compared the changes in allergen sensitization in children diagnosed with allergic diseases us-ing the skin test and the multiple allergen simultaneous test. Methods: We retrospectively analyzed the data on children who were diagnosed with allergic diseases and received immunother-apy at Yonsei Medical Center from 1980 to 1998 and they were screened for allergen sensitization at Severance Hospital from 2005 to 2019. Results: Between 1980 and 1998, and between 2005 and 2019, data on 3,205 (male, 70.3%; mean age, 7.2±2.9 years) and 15,318 children (male, 62.8%; mean age, 8.8±4.5 years) were analyzed. The sensitized allergens that appeared in the 1980-1998 included Dermatophagoides farinae (91.0%), Dermatophagoides pteronyssinus (76.3%), cockroach (13.5%), and Alternaria (11.5%), in order of frequency; further, the sensitized allergens that appeared in the 2005-2019 included D. farinae (45.0%), D. pteronyssinus (39.6%), cat dander (12.2%), and dog dander (9.1%), in order of frequency. D. farinae and D. pteronyssinus demonstrated the highest sensitization rates, although the rates decreased gradually. The sensitization to cat dander and dog dander showed a growing trend, and sensiti-zation to Humulus japonicus, Candida, and cockroach decreased after 2005. Conclusion: Over the past 40 years, the allergen sensitization in Korean children with allergic diseases has increased. These changes reflect lifestyle and environmental changes and influence allergic disease management approaches. Thus, changes in allergic sensi-tization should be monitored continuously. (Allergy Asthma Respir Dis 2021;9:208-215)
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