Minaprine의 말초 항콜린 효과에 관한 연구

박묵희,이종범,정성덕 영남대학교 의과대학 1989 Yeungnam University Journal of Medicine Vol.6 No.2

Minaprine의 말초 항콜린 작용 유무를 판별하기 위하여 백서를 단두 사혈하여 적출된 십이지장, 상행결장, 방광으로부터의 평활근절편을 사용하여 atropine의 bethanechol작용 차단 능력을 기준으로하여 minaprine의 차단 능력을 비교하여 다음과 같은 결과를 얻었다. 십이지장 절편에서 atropine ?? 존재하에서의 bethanechol에 대한 ED50는 대조군에 비하여 유의한 차이를 보였으나(P<0.01), minaprine ?? 및 ?? 존재하의 bethanechol에 대한 ED50는 대조군에 비하여 유의한 차이가 없었다. 상행결장 절편에서 atropine ?? 존재하에서의 bethanechol에 대한 ED50는 대조군에 비하여 유의한 차이를 보였으나(P<0.01), minaprine ?? 및 ?? 존재하의 bethanechol에 대한 ED50는 대조군에 비하여 유의한 차이가 없었다. 방광 절편에서 atropine ?? 존재하에서의 bethanechol에 대한 ED50는 대조군에 비하여 유의한 차이를 보였으며(P<0.01), minaprine ?? 및 ?? 존재하의 bethanechol에 대한 ED50는 대조군에 비하여 모두 유의한 차이를 보였다(P<0.01). 그러나 minaprine ?? 존재하의 bethanechol에 대한 ED50는 atropine ?? 존재하의 bethanechol에 대한 ED50에 비해 유의한 차이를 보였다.(P<0.05) The authors studied ED50 of bethanechol on the contractilities of the smooth muscles isolated from various organs of rat under the presence of atropine(a classical competitive blocker of cholinergic muscarinic receptor) or minaprine(a newly developed antidepressant drug) to investigate the pheripheral anticholinergic effect of minaprine. The results were as follows : 1) There was no significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine ?? and ?? in the smooth muscles isolated from the duodenum. 2) There was no significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine ?? and ?? in the smooth muscles isolated from the ascending colon. 3) There was no significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine ?? and ?? in the smooth muscles isolated from the urinary bladder(P<0.01) 4) There was no significant difference between ED50 of the atropine ?? and minaprine?? in the smooth muscles isolated from the urinary bladder(P<0.05).

공황발작과 승모판 탈출

민성길,박묵희,이호영 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.2

Of 72 Korean patients with recurrent spontaneous panic attacks, none had definite mitral valve prolapse(MVP). With a very low prevalence of MVP in the general population of Korea, this finding suggests that panic disorder without MVP is a universal one regardless of ethnic difference and that the two conditions might be dissociated. Furthermore, panic attack might not be the expression of a genetically determined biological defect which also is underlying MVP. However as seen in the case history of patient with MVP who had felt anxiety symptoms with cardiac symptoms caused by MVP, it is still possible that another form of spontaneous panic attack triggered by arrhythmia of MVP exists.

Sulpiride와 Chlorpromazine의 만성정신분열증에 대한 치료효과

민성길,박정주,박묵희,이후경,윤경수,이호영 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.2

The clinical effects of sulpride were compared with those of chlorpromazine on the chronic schizophrenia. The dosage of sulpiride was 1200㎎/day and that of chlorpromazine was 300㎎/day. The treatment period was 8 weeks after washout period. The clinical effect was evaluated by psychiatrists who were blind for the kind of drugs. The instruments for evaluation were BPRS, Hamilton's depression scale, NOSIE, global assessment scale, positive symptom scale and negative symptom scale. The results showed that sulpiride had similar effects to chlorpromazine. Especially sulpirde had less sedating and more antidepressant effects, more effectiveness in negative symptoms and initiativeness. However, extrapyramidal symptoms were more with sulpiride, probably because of high dose. These findings suggest that supiride is an antipsychotic drug which can be used selectively.

미혼 의과대학생들의 성행위에 관한 연구

이홍식,유계준,박묵희,이호영 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.4

In order to study sexual behavior among unmarried college students, the author conducted a survey by questionnaire method to 710 unmarried medical students of the Yonsei University College of Medicine (male:573, female:137). The questionnaire is consist of 74 items which can get general informations of sexual behavior and attitudes. The results of this survey are summarized as follows. 1) Most students experienced their first ejaculation (orgasm) through masturbation (male:75.7%, female:60.7%). 2) According to our data, 95.7% of the male students and 61.4% of the female students have masturbatory experiences. 89.3% of the male students and about half of the female students utilized manual stimulation During one year prior to the questionnaire, 75% of the male students and 27.5% of the female students have masturbated at least once per weak. The average age of the first masturbatory experience was 15.2±3.7 years for the male and female students respectively. The male students initiated masturbation significantly earlier than the female students. 3) 31.1% of the male students and 10% of the female students have experience sexual coitus. The average age of the first coital experience was 20.0±2.4 years for male students, 19.0±4.34 years for the female students. There was no significant age difference of the first coital experience between male and female. Their first coital partner was a prostitute in 50% of the male students. For the female students, their first coital partner was either a boyfriend or a lover in 75% of those who have experienced coitus. During one uear prior to the wurvey, 40.9% of the experienced male students had sexual coitus at least once per month, however, about 65% of the experienced female students had sexual coitus only once or twice per year. There was significant difference of the frequency of sexual coitus between male and female students. 4) The religion was not a significant factor in masturbation and coitus experiences. However, among those who had a religion, highly religious students showed significantly lower rate of masturbation and coitus experience than less religiously inclined students.

한국판 진단적 면담검사의 개발과 그 타당도 검사 : 강화도 정신과 역학 연구(I) Kangwha Psychiatric Epidemiologic Survey(I)

이만홍,이호영,민성길,김경희,김수영,송동호,신정호,박묵희,배안,송금영 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.2

Because the NIMH-Diagnostic Interview Schedule(DIS), a fully structured and computer-analyzable diagnostic instrument, was developed for the use of large-scale epidemiologic studies such as the ECA program in the United States, it can be most suitably applied to our Kangwha Psychiatric Epidemiologic Survey, that is the first step of our ongoing Kangwha Mental Health project for the development of psychiatric service delivery system & community mental health modality in Korea. The authors presented translation procedure of the DIS-ⅢA version and subsequent editing of korean version, and discussed several problems occurring in the procedures as transcultural point of view. The concurrent validity of Korean version has been also studied by calculating agreement(kappa value)between DIS diagnosis by lay-interviewers and clinical diagnoses by psychiatrists according to the line of DIS-ⅢA with exclusion criteria. The subjects included in this validity study were 155 selected from 5 different psychiatric clinic of both inpatient and outpatient services. The DIS interviewers who had been trained for two weeks according to NIMH-St.Louis group workshop schedule. Independent clinical diagnoses for each subject were obtained by psychiatrists and their intake diagnostic conference procedures. The results were as follows; 1)Various sections of DIS-ⅢA, especially somatization and major depression section were inevitably modified as the result of transcultural considerations. 2)kappa values of agreement are rather low in neurotic disorders such as panic(0.2), generalized anxiety disorder(0.49) without statistical significance, but rather high in the remaining disorders showing between 0.63 and 0.81. 3)The Kappa value of somatization disorder is 0.66, higher than expected before this study, and it can be possibly increased up to 0.92 by adding supplementary 21 items of culture-bound symptom complaints.