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박대명 ( Dae Myung Park ),이상룡 ( Sang Ryong Lee ),강위창 ( Wee Chang Kang ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.2
Objectives: This study was performed to develop a standard instrument of Pattern Identification for jing ji and zheng chong. Methods: The advisor committee on this study was organized by 15 neuropsychiatry professors of oriental medical colleges. The items and structure of the instrument were based on review of published literature. We took consultation 2 times from the advisor committee and we also took additional advices by e-mail. Results: 1. We divided the symptoms and signs of jing ji and zheng chong into 9 pattern identification. - heart deficiency with timidity(心膽虛怯), heart qi deficiency(心氣虛), heart blood deficiency(心血虛), heart yang inactivity(心陽不振), heart blood stasis(心血瘀阻), phlegm turbidity obstructing(痰濁阻滯), yin deficiency with effulgent fire(陰虛火旺), water qi intimidating the heart(水氣凌心), dual deficiency of the heart and spleen(心脾兩虛). 2. We got the mean weights that reflect standard deviation to each symptom of 9 pattern identification which had been scored on a 100-point scale. 3. We made out the Korean instrument of the pattern identification for jing ji and zheng chong. It was composed of 17 questions in question-and-answer form. Conclusions: Instrument of Pattern Identification for jing ji and zheng chong was developed through experts` disscussion. If the validity and reliability of this instrument is confirmed through additional clinical trial, the instrument of pattern identification for jing ji and zheng chong is expected to be applied to the subsequent research.
ACM의 Rat를 이용한 13주 반복 경구투여 독성시험 및 4주 회복시험
박대명 ( Dae Myung Park ),이상룡 ( Sang Ryong Lee ),임종순 ( Jong Soon Lim ),김승형 ( Seung Hyung Kim ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2012 동의신경정신과학회지 Vol.23 No.3
Objectives : To provide information on the safety of ACM, we carried out a 13-week repeated oral dose toxicity and a 4-week recovery test of ACM in Sprague-Dawley rats. Methods : Female and male rats were treated with ACM with oral doses of 800, 2000, and 5000 ㎎/㎏. The ACM was administered for 13 weeks. Mortality, clinical signs, body weight changes, food consumption, ophthalmologic findings, urinalysis, hematological and biochemical parameters, gross findings, organ weights and histological markers were monitored during the study period. Moreover, the rats were monitored for 4 extra weeks to determine recovery time after the study period. Results : We found no mortality and no abnormalities in clinical signs, body weight, food consumption, ophthalmologic findings, urinalysis, hematological and biochemical parameters, gross findings, organ weights and histological markers in any of the rats tested. Conclusions : The no-observed adverse effects level (NOAEL) was considered as over 5000 mg/kg for male and female rats.
도담탕합총명탕(導痰湯合聰明湯)이 LPS로 처리된 microglia 및 기억력 감퇴 생쥐 모델에 미치는 영향
박대명 ( Dae Myung Park ),이상룡 ( Sang Ryong Lee ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.2
Objectives: This experiment was designed to investigate the efficacy of DDTCMT hot water extract & ultra-fine powder on Alzheimer`s Disease Model. Methods: The effects of the DDTCMT hot water extract on expression of IL-1β, IL-6, TNF-α, COX-2, NOS-Ⅱ, IL-10, IL-1 receptor antagonist mRNA and production of IL-1β, IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. Expression of NO, ROS in BV2 microglial cell line treated by LPS and AChE activity in PC-12 cell treated by NGF were investigated. anti-AChE was observed through Western blot analysis. The effects of the DDTCMT hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine were investigated. Results: 1. The DDTCMT hot water extract significantly decreased the production of mIL-6, mNOS-Ⅱ, mTNF-α, and increased the production of mIL-10, mIL-1 receptor antagonist. 2. The DDTCMT hot water extract significantly suppressed the production of IL-1β, IL-6, TNF-α in BV2 microglial cell line treated by LPS. 3. The DDTCMT hot water extract significantly suppressed the NO and ROS production in BV2 microglial cell line treated by LPS. 4. The DDTCMT hot water extract groups showed inhibition of AChE activity in NGF treated PC-12 cell line. 5. The DDTCMT hot water extract suppressed anti-AChE expression in NGF treated PC-12 cell line was observed by Western blot analysis. 6. The DDTCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine -induced impairment of memory in the experiment of Morris water maze. Conclusions: These results suggest that the DDTCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer`s disease.
화병 변증도구와 한의 평가도구를 적용한 화병 치험 3례
박대명 ( Dae Myung Park ),이상룡 ( Sang Ryong Lee ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.1
Objectives: This case series was conducted to report the efficacy of traditional Korean medicine treatments for Hwa-Byung. Methods: Patients were diagnosed with Hwa-byung through Hwa-Byung diagnostic interview schedule(HBDIS). instrument of pattern identification for Hwa-Byung was applied to develop an individualized traditional Korean medicine treatment plan. SCL-90-R, STAI, STAXI, BDI, and instrument of oriental medical evaluation for Hwa-Byung were measured. After 2 weeks of tradiational Korean medicine treatments and K-MBSR practice, STAI, STAXI, BDI, and instrument of oriental medical evaluation for Hwa-Byung were re-assessed to determine the progress of Hwa-Byung. Results: After treatments, chief complaints have improved. STAI, STAXI, BDI and instrument of oriental medical evaluation for Hwa-Byung score have decreased. Conclusions: According to the study, traditional Korean medicine treatments using instrument of pattern identification for Hwa-Byung have shown positive results in managing Hwa-Byung symptoms evaluated by instrument of oriental medical evaluation for Hwa-Byung.
우울, 불안, 불면 환자에 대한 심리척도의 유용성과 상관성에 대한 임상연구
박대명 ( Dae Myung Park ),이상룡 ( Sang Ryong Lee ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2012 동의신경정신과학회지 Vol.23 No.3
Objectives : The aim of this study was to investigate the value and efficacy of BDI, STAI, STAXI, ISI, and SCL-90-R in correlation with depression, anxiety, and insomnia patients. Methods : A total of 39 patients, who were diagnosed with depression, anxiety, and insomnia were evaluated using BDI, STAI, STAXI, ISI, and SCL-90-R. They were then statistically analyzed. Results : 1. BDI scores of depression patients were significantly different from other patients. 2. BDI scores of depression patients had strong positive correlation with STAI-S, and STAI-T scores. 3. STAI-S scores of anxiety patients had positive correlation with BDI, and ISI scores. 4. SCL-90-R depression subscale scores of depression patients had strong positive correlation with somatization, obsessive compulsive, interpersonal sensitivity, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism, global severity index, and positive symptom total subscale scores. 5. SCL-90-R anxiety subscale scores of anxiety patients had strong positive correlation with somatization, obsessive compulsive, depression, phobic anxiety, and global severity index subscale scores. Phobic anxiety subscale scores had strong positive correlation with anxiety, global severity index, and positive symptom total subscale scores. Conclusions : The result findings are expected to serve as a useful resource in future stress-related depression, anxiety, and insomnia case reports and clinical research in oriental neuropsychiatry.
온담탕가미(溫膽湯加味) 투여 후 수면의 질이 개선된 환자 치험 3례
박대명 ( Dae Myung Park ),이상룡 ( Sang Ryong Lee ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.4
Objectives: This case series was conducted to report the efficacy of Ondam-tanggami for insomnia. Methods: Insomnia patients with more than 15 points on Insomnia Severity Index scale were assessed using SCL-90-R, STAI, STAXI, BUI. Being treated with Ondam-tanggami after 2 weeks, ISI, STAI, STAXI, BDI were re-measured to determine the progress of insomnia. It is measured that total sleep time, number of awaking times during sleep, satisfaction of sleep daily. Results: After treatment, quality of sleep has improved and ISI, STAI, STAXI, BUI score have decreased. Conclusions: According to the study, treatment with Ondam-tanggami for insomnia has shown positive results. Further use of Ondam-tanggami is much anticipated for future treatment of insomnia cases.
주유두부 배액술로 치료한 불완전 분할췌 동반 췌담관 합류 이상 1예
김민희 ( Min Hee Kim ),이재광 ( Jae Kwang Lee ),김현수 ( Hyun Soo Kim ),박인 ( In Park ),박진경 ( Jin Kyung Park ),오대명 ( Dae Myung Oh ),하재현 ( Jae Hyun Ha ) 대한췌담도학회 2018 대한췌담도학회지 Vol.23 No.2
췌담관 합류 이상은 췌관과 총수담관의 합류가 십이지장벽 외부에서 이루어지고 공통관이 비정상적으로 길어지는 선천성 기형이다. 이로 인해 오디괄약근의 지배를 받지 않아 췌액과 담즙의 상호 역류가 일어나고 담관 낭종, 담석, 담관염, 췌장염 등의 합병증과 담관암, 담낭암과 같은 악성 종양이 발생할 수 있다고 알려져 있다. 분할췌는 태생기에 복측 췌관과 배측 췌관의 융합 실패로 발생하고 췌액이 주유두와 부유두를 통해 각각 십이지장으로 배출되며 상대적으로 많은 양의 췌액이 직경이 작은 부유두 개구부를 통해 배출됨으로써 췌액의 저류가 발생하게 되어 췌장염이 반복적으로 발생하는 원인이 될 수 있다. 본 증례는 우상복부 통증을 주소로 내원한 35세 여자 환자로 내시경적 역행성 담췌관 조영술을 통하여 담관 낭종이 없는 췌담관 합류 이상과 동반된 불완전 분할췌를 발견하여 보고하는 바이다. Anomalous union of the pancreaticobiliary duct (AUPBD) is a rare congenital anomaly, defined as the pancreaticobiliary ductal union located outside of the duodenal wall, usually forming a markedly long common channel. This anomaly is associated with congenital choledochal cyst, carcinoma of the biliary tract and pancreatitis, and is more commonly seen in Asian than in Western countries. AUPBD is frequently accompanied by biliary dilatation, but some patients with AUPBD have no biliary dilatation. The causal relationship between AUPBD and biliary dilatation associated with this anomaly has not been fully established. Here, we report a case of type IIIc2 AUPBD without biliary duct dilatation that was treated by drainage of major papilla.