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갑상선 기능항진증 환자에서 방사선 옥소 투여후 Interleukin-6 치의 변화에 관한 연구
박근용 대한내분비학회 1995 Endocrinology and metabolism Vol.10 No.3
Interleukin-6(IL-6) is a cytokine secreted from lymphocytes or non-lymphoid cell(monocyte, fibroblast, osteoblast, vascular endothelial cell, or synoviocytes). Increased serum IL-6 concentrations have recently been reported in patients with subacute thyroiditis, possibly because of cytokine release damaged thyroid cells. In this study, IL-6 levels serum T_3, T_4, Thyroglobulin(Tg) and TSH were determined by an radioimmunoassay method in 14 patients treated with radioactive iodine(10mci) for Graves' disease. IL-6 levels were as follows: 23.9+-0.8 fmol/ml(at baseline), 25.4+-1.1 fmol/ml(1hour), 24.7+-0.6 fmol/ml(24hours), 76.8+-2.0 fmol/ml(48hours), 22.8+-0.5 fmol/ml(72hours). There was significant increase in IL-6 values at 48hours after RAI treatment(p<0.01). Serum Tg, T_3 and T_4 also increased after RAI treatment, but no significant correlation could be demonstrated with the increase in L-6. The results of this study support the concept that IL-6 can be regarded as a useful marker of thyroid-destructive processes(J Kor Soc Endocrinol 10: 214-219, 1995).
폐경기 여성에서 지속적 에스트로겐 / 프로제스테론 병합요법시 프로제스테론이 골밀도 및 지질대사에 미치는 영향
박근용 대한내분비학회 1995 Endocrinology and metabolism Vol.10 No.4
A study in 51 healthy postmenopausal women was performed to assess the effect of estrogen replacement therapy continuously combined with progesterone for 6 months on bone mineral density and lipid metabolism. Seventeen hysterectomized women were treated with conjugated estrogen(0.625mg/D), 33 nonhysterectomized women with conjugated estrogen(0.625mg/D) and medroxyprogesterone(2.5mg/D), and 1500mg/day calcium supplementation was given to all patients. After 6 month-treatment, serum total cholesterol and LDL-cholesterol levels were reduced significantly (p$lt;0.01) between the two groups. But lumber BMD and other lipid profiles were not changed significantly between the two groups. Our data suggest that continuously applied progesterone in combined hormone replacement therapy dose not annihilate the beneficial effects on bone mineral density and lipid metabolism induced by estrogen(J Kor Soc Endocrinol 10: 411-417, 1995).